C₁₈H₁₆N₂OS

Base Information

Chemical Name:C₁₈H₁₆N₂OS
CAS No.:1446715-70-3
Molecular Formula:C₁₈H₁₆N₂OS
Molecular Weight:308.404
Hs Code.:

C<sub>18</sub>H<sub>16</sub>N<sub>2</sub>OS

Synonyms:

Suppliers and Price of C₁₈H₁₆N₂OS

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of C₁₈H₁₆N₂OS

Chemical Property:

Purity/Quality:

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Technology Process of C₁₈H₁₆N₂OS

There total 5 articles about C₁₈H₁₆N₂OS which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 22900-83-0
ethyl 2-bromo-4-methyl-1,3-thiazole-5-carboxylate

: 1446715-70-3
C₁₈H₁₆N₂OS

Guidance literature:: Multi-step reaction with 5 steps

1: 2,2'-azobis(isobutyronitrile); N-Bromosuccinimide / tetrachloromethane

2: potassium carbonate / N,N-dimethyl-formamide / Heating

3: lithium hydroxide / tetrahydrofuran; water / 15 h / 20 °C

4: triethylamine; benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate / dichloromethane / 20 h / 20 °C / Reflux

5: bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; triethylamine / 0.25 h / 140 °C / Microwave irradiation

With bis-triphenylphosphine-palladium(II) chloride; N-Bromosuccinimide; copper(l) iodide; 2,2'-azobis(isobutyronitrile); benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; potassium carbonate; triethylamine; lithium hydroxide; In tetrahydrofuran; tetrachloromethane; dichloromethane; water; N,N-dimethyl-formamide; 5: |Sonogashira Cross-Coupling;
DOI:10.1016/j.bmcl.2013.05.070

Reference yield:

: 1446716-50-2
C₁₂H₁₇BrN₂O₂S

: 1446715-70-3
C₁₈H₁₆N₂OS

Guidance literature:: Multi-step reaction with 3 steps

1: lithium hydroxide / tetrahydrofuran; water / 15 h / 20 °C

2: triethylamine; benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate / dichloromethane / 20 h / 20 °C / Reflux

3: bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; triethylamine / 0.25 h / 140 °C / Microwave irradiation

With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; triethylamine; lithium hydroxide; In tetrahydrofuran; dichloromethane; water; 3: |Sonogashira Cross-Coupling;
DOI:10.1016/j.bmcl.2013.05.070

Reference yield:

: 949019-55-0
ethyl-2-bromo-4-(bromomethyl)thiazole-5-carboxylate

: 1446715-70-3
C₁₈H₁₆N₂OS

Guidance literature:: Multi-step reaction with 4 steps

1: potassium carbonate / N,N-dimethyl-formamide / Heating

2: lithium hydroxide / tetrahydrofuran; water / 15 h / 20 °C

3: triethylamine; benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate / dichloromethane / 20 h / 20 °C / Reflux

4: bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; triethylamine / 0.25 h / 140 °C / Microwave irradiation

With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; potassium carbonate; triethylamine; lithium hydroxide; In tetrahydrofuran; dichloromethane; water; N,N-dimethyl-formamide; 4: |Sonogashira Cross-Coupling;
DOI:10.1016/j.bmcl.2013.05.070