2-[3-(Hydroxymethyl)phenoxy]acetonitrile

Base Information

Chemical Name:2-[3-(Hydroxymethyl)phenoxy]acetonitrile
CAS No.:123226-30-2
Molecular Formula:C9H9NO2
Molecular Weight:163.176
Hs Code.:
DSSTox Substance ID:DTXSID70462212
Mol file:123226-30-2.mol

Synonyms:2-[3-(hydroxymethyl)phenoxy]acetonitrile;123226-30-2;SCHEMBL4850094;DTXSID70462212;FQYJUMVWCVSLPH-UHFFFAOYSA-N;AKOS000247976;alpha-(3-Hydroxymethylphenoxy)acetonitrile

Suppliers and Price of 2-[3-(Hydroxymethyl)phenoxy]acetonitrile

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 1 raw suppliers

Chemical Property of 2-[3-(Hydroxymethyl)phenoxy]acetonitrile

Chemical Property:

XLogP3:0.9
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:3
Exact Mass:163.063328530
Heavy Atom Count:12
Complexity:173

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1=CC(=CC(=C1)OCC#N)CO

Technology Process of 2-[3-(Hydroxymethyl)phenoxy]acetonitrile

There total 1 articles about 2-[3-(Hydroxymethyl)phenoxy]acetonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 620-24-6
3-Hydroxybenzyl alcohol

: 590-17-0
cyanomethyl bromide

: 123226-30-2
α-(3-Hydroxymethylphenoxy)acetonitrile

Guidance literature:: With potassium carbonate; In N,N-dimethyl-formamide; acetone; for 72h; Heating;
DOI:10.1021/jm00166a017

Reference yield:

: 123226-30-2
α-(3-Hydroxymethylphenoxy)acetonitrile

: 123226-31-3
α-(3-chloromethylphenoxy)acetonitrile

Guidance literature:: With thionyl chloride; N,N-dimethyl-formamide; In dichloromethane; for 16h; Ambient temperature;
DOI:10.1021/jm00166a017

Reference yield:

: 123226-30-2
α-(3-Hydroxymethylphenoxy)acetonitrile

: 123225-69-4
5-(3-(3-(2-quinolinylmethyloxy)phenoxymethyl)phenoxymethyl)tetrazole

Guidance literature:: Multi-step reaction with 3 steps

1: SOCl₂, DMF / CH₂Cl₂ / 16 h / Ambient temperature

2: NaOH / dimethylsulfoxide / 16 h / Ambient temperature

3: sodium azide, NH₄Cl / dimethylformamide / 24 h / 100 - 110 °C

With sodium hydroxide; thionyl chloride; sodium azide; ammonium chloride; N,N-dimethyl-formamide; In dichloromethane; dimethyl sulfoxide; N,N-dimethyl-formamide;
DOI:10.1021/jm00166a017