Pyrido[2,3-b]pyrazine, 2,3-diphenyl-

Base Information

• Chemical Name: Pyrido[2,3-b]pyrazine, 2,3-diphenyl-
• CAS No.: 1232-99-1
• Molecular Formula: C19H13N3
• Molecular Weight: 283.332
• DSSTox Substance ID: DTXSID60355821
• Nikkaji Number: J2.056.620E
• Wikidata: Q82134883
• ChEMBL ID: CHEMBL2139680
• Mol file: 1232-99-1.mol

Synonyms:2,3-diphenylpyrido[2,3-b]pyrazine;1232-99-1;pyrido[2,3-b]pyrazine,2,3-diphenyl-;Oprea1_757129;MLS001180450;SCHEMBL284971;CHEMBL2139680;DTXSID60355821;RBAXWBRRSJYIIW-UHFFFAOYSA-N;HMS2797P16;2,3-diphenylpyrido[3,2-b]pyrazine;MFCD00234934;2,3-Diphenylpyridino[3,2-b]pyrazine;AKOS005109528;MS-7404;SMR000475737

Chemical Property of Pyrido[2,3-b]pyrazine, 2,3-diphenyl-

Chemical Property:

• XLogP3: 3.8
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 2
• Exact Mass: 283.110947427
• Heavy Atom Count: 22
• Complexity: 347

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC=C(C=C1)C2=NC3=C(N=CC=C3)N=C2C4=CC=CC=C4

Technology Process of Pyrido[2,3-b]pyrazine, 2,3-diphenyl-

There total 11 articles about Pyrido[2,3-b]pyrazine, 2,3-diphenyl- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

2,3-Diaminopyridine (452-58-4) + benzil (134-81-6) → 2,3-diphenylpyrido[3,2-b]pyrazine (1232-99-1)

Guidance literature:

With silica-supported bismuth(III) chloride; In methanol; at 20 ℃; for 0.5h; Catalytic behavior;

DOI:10.1016/j.jorganchem.2013.06.037

Reference yield: 91.0%

2,3-Diaminopyridine (452-58-4) + 2-hydroxy-2-phenylacetophenone (119-53-9,579-44-2) → 2,3-diphenylpyrido[3,2-b]pyrazine (1232-99-1)

Guidance literature:

With hexaammonium heptamolybdate tetrahydrate; at 90 ℃; for 0.25h; Catalytic behavior; Microwave irradiation;

DOI:10.1016/j.crci.2012.06.007

Reference yield: 90.0%

2,3-Diaminopyridine (452-58-4) + 1,2-diphenyl-1,2-ethanediol (492-70-6,655-48-1,2325-10-2,38270-73-4,52340-78-0,579-43-1) → 2,3-diphenylpyrido[3,2-b]pyrazine (1232-99-1)

Guidance literature:

With sodium hydroxide; In water; toluene; at 20 ℃; for 39h;

DOI:10.1002/cctc.201402782

upstream raw materials:

2,3-Diaminopyridine

benzil

7-bromo-2,3-diphenyl-5-azaquinoxaline

2,2'-iminobis[ethanol]

Downstream raw materials:

2,3-diphenyl-8-<(phenylsulfonyl)methyl>pyrido<2.3-b>pyrazine

1a,1b,2,7b-tetrahydro-5,6-diphenyl-1,2-bis(phenylsulfonyl)-1H-azirino<1'.2':1.6>cyclopropa<4.5>pyrido<2.3>pyrazine

diphenyl-2,3 tetrahydro-5,6,7,8 pyrido<2,3-b>pyrazine

cis-diphenyl-2,3 tetrahydro-1,2,3,4 pyrido<2,3-b>pyrazine