((2S,4R)-2-{2-[Bis-(4-fluoro-phenyl)-methyl]-4,6-dichloro-phenylsulfanylmethyl}-6-methoxy-tetrahydro-pyran-4-yloxy)-tert-butyl-diphenyl-silane

Base Information

Chemical Name:((2S,4R)-2-{2-[Bis-(4-fluoro-phenyl)-methyl]-4,6-dichloro-phenylsulfanylmethyl}-6-methoxy-tetrahydro-pyran-4-yloxy)-tert-butyl-diphenyl-silane
CAS No.:116041-87-3
Molecular Formula:C₄₂H₄₂Cl₂F₂O₃SSi
Molecular Weight:763.848
Hs Code.:

((2S,4R)-2-{2-[Bis-(4-fluoro-phenyl)-methyl]-4,6-dichloro-phenylsulfanylmethyl}-6-methoxy-tetrahydro-pyran-4-yloxy)-tert-butyl-diphenyl-silane

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Chemical Property of ((2S,4R)-2-{2-[Bis-(4-fluoro-phenyl)-methyl]-4,6-dichloro-phenylsulfanylmethyl}-6-methoxy-tetrahydro-pyran-4-yloxy)-tert-butyl-diphenyl-silane

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Technology Process of ((2S,4R)-2-{2-[Bis-(4-fluoro-phenyl)-methyl]-4,6-dichloro-phenylsulfanylmethyl}-6-methoxy-tetrahydro-pyran-4-yloxy)-tert-butyl-diphenyl-silane

There total 11 articles about ((2S,4R)-2-{2-[Bis-(4-fluoro-phenyl)-methyl]-4,6-dichloro-phenylsulfanylmethyl}-6-methoxy-tetrahydro-pyran-4-yloxy)-tert-butyl-diphenyl-silane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

: 116041-84-0
4,6-dichloro-2-thiphenol

: 86031-03-0,108034-28-2,116126-75-1
2(RS)-methoxy-4(R)-(tert-butyldiphenylsilyloxy)-6(S)-(iodomethyl)tetrahydropyran

: 116041-87-3,136034-12-3
((2S,4R)-2-{2-[Bis-(4-fluoro-phenyl)-methyl]-4,6-dichloro-phenylsulfanylmethyl}-6-methoxy-tetrahydro-pyran-4-yloxy)-tert-butyl-diphenyl-silane

Guidance literature:: With potassium carbonate; hydroquinone; In dimethyl sulfoxide; at 50 ℃; for 1h;
DOI:10.1021/jm00114a004

Reference yield:

: 403-43-0
4-fluorobenzoyl chloride

: 116041-87-3,136034-12-3
((2S,4R)-2-{2-[Bis-(4-fluoro-phenyl)-methyl]-4,6-dichloro-phenylsulfanylmethyl}-6-methoxy-tetrahydro-pyran-4-yloxy)-tert-butyl-diphenyl-silane

Guidance literature:: Multi-step reaction with 8 steps

1: 99 percent / NaOH / H₂O / 0.5 h

2: 81 percent / AlCl₃ / 2 h / 150 °C

3: 85 percent / tetrahydrofuran

4: 74 percent / H₂, conc. HCl / 10percent Pd/C / acetic acid / 1.5 h / 25 °C / 750.06 Torr

5: 1.) NaH / 1.) mineral oil, DMF, 25 deg C, 30 min, 2.) mineral oil, DMF, 80 deg C, 2 h

6: 80 percent / 0.5 h / 275 °C

7: 100 percent / LiAlH₄ / diethyl ether / 90 h / 25 °C

8: 65 percent / K₂CO₃, hydroquinone / dimethylsulfoxide / 1 h / 50 °C

With hydrogenchloride; sodium hydroxide; lithium aluminium tetrahydride; aluminium trichloride; hydrogen; sodium hydride; potassium carbonate; hydroquinone; palladium on activated charcoal; In tetrahydrofuran; diethyl ether; water; acetic acid; dimethyl sulfoxide;
DOI:10.1021/jm00114a004

Reference yield:

: 114865-95-1
(3,5-dichloro-2-hydroxyphenyl)-(4-fluorophenyl)methanone

: 116041-87-3,136034-12-3
((2S,4R)-2-{2-[Bis-(4-fluoro-phenyl)-methyl]-4,6-dichloro-phenylsulfanylmethyl}-6-methoxy-tetrahydro-pyran-4-yloxy)-tert-butyl-diphenyl-silane

Guidance literature:: Multi-step reaction with 6 steps

1: 85 percent / tetrahydrofuran

2: 74 percent / H₂, conc. HCl / 10percent Pd/C / acetic acid / 1.5 h / 25 °C / 750.06 Torr

3: 1.) NaH / 1.) mineral oil, DMF, 25 deg C, 30 min, 2.) mineral oil, DMF, 80 deg C, 2 h

4: 80 percent / 0.5 h / 275 °C

5: 100 percent / LiAlH₄ / diethyl ether / 90 h / 25 °C

6: 65 percent / K₂CO₃, hydroquinone / dimethylsulfoxide / 1 h / 50 °C

With hydrogenchloride; lithium aluminium tetrahydride; hydrogen; sodium hydride; potassium carbonate; hydroquinone; palladium on activated charcoal; In tetrahydrofuran; diethyl ether; acetic acid; dimethyl sulfoxide;
DOI:10.1021/jm00114a004