1-((S)-2-{[4-(tert-Butoxycarbonylamino-methyl)-cyclohexanecarbonyl]-amino}-3-phenyl-propionylamino)-cyclohexanecarboxylic acid benzyl ester

Base Information

• Chemical Name: 1-((S)-2-{[4-(tert-Butoxycarbonylamino-methyl)-cyclohexanecarbonyl]-amino}-3-phenyl-propionylamino)-cyclohexanecarboxylic acid benzyl ester
• CAS No.: 207514-75-8
• Molecular Formula: C₃₆H₄₉N₃O₆
• Molecular Weight: 619.802
• Mol file: 207514-75-8.mol

Synonyms:

Chemical Property of 1-((S)-2-{[4-(tert-Butoxycarbonylamino-methyl)-cyclohexanecarbonyl]-amino}-3-phenyl-propionylamino)-cyclohexanecarboxylic acid benzyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-((S)-2-{[4-(tert-Butoxycarbonylamino-methyl)-cyclohexanecarbonyl]-amino}-3-phenyl-propionylamino)-cyclohexanecarboxylic acid benzyl ester

There total 2 articles about 1-((S)-2-{[4-(tert-Butoxycarbonylamino-methyl)-cyclohexanecarbonyl]-amino}-3-phenyl-propionylamino)-cyclohexanecarboxylic acid benzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

C18H31NO6 (263272-46-4) + 1-((S)-2-Amino-3-phenyl-propionylamino)-cyclohexanecarboxylic acid benzyl ester; compound with trifluoro-acetic acid → 1-((S)-2-{[4-(tert-Butoxycarbonylamino-methyl)-cyclohexanecarbonyl]-amino}-3-phenyl-propionylamino)-cyclohexanecarboxylic acid benzyl ester (207514-75-8)

Guidance literature:

With triethylamine; In tetrahydrofuran; at 6 ℃; Yield given;

DOI:10.1248/cpb.46.452

Reference yield:

trans 4-(tert-butyloxycarbonylamino)methylcyclohexanecarboxylic acid (27687-14-5) → 1-((S)-2-{[4-(tert-Butoxycarbonylamino-methyl)-cyclohexanecarbonyl]-amino}-3-phenyl-propionylamino)-cyclohexanecarboxylic acid benzyl ester (207514-75-8)

Guidance literature:

Multi-step reaction with 2 steps

1: Et₃N

2: Et₃N / tetrahydrofuran / 6 °C

With triethylamine; In tetrahydrofuran;

DOI:10.1248/cpb.46.452

Reference yield:

1-((S)-2-{[4-(tert-Butoxycarbonylamino-methyl)-cyclohexanecarbonyl]-amino}-3-phenyl-propionylamino)-cyclohexanecarboxylic acid benzyl ester (207514-75-8) → 1-((S)-2-{[4-(tert-Butoxycarbonylamino-methyl)-cyclohexanecarbonyl]-amino}-3-phenyl-propionylamino)-cyclohexanecarboxylic acid

Guidance literature:

With hydrogen; palladium on activated charcoal;

DOI:10.1248/cpb.46.452

upstream raw materials:

C₁₈H₃₁NO₆

trans 4-(tert-butyloxycarbonylamino)methylcyclohexanecarboxylic acid