2,3-diphenyl-5a-(1-hydroxyethyl)-4a,5a,6,7-tetrahydro-5H-cyclopropaimidazo<1,2-a>pyrimidine-4a-carboxylic acid lactone

Base Information

Chemical Name:2,3-diphenyl-5a-(1-hydroxyethyl)-4a,5a,6,7-tetrahydro-5H-cyclopropaimidazo<1,2-a>pyrimidine-4a-carboxylic acid lactone
CAS No.:82874-63-3
Molecular Formula:C₂₂H₁₉N₃O₂
Molecular Weight:357.412
Hs Code.:

2,3-diphenyl-5a-(1-hydroxyethyl)-4a,5a,6,7-tetrahydro-5H-cyclopropa<e>imidazo<1,2-a>pyrimidine-4a-carboxylic acid lactone

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Chemical Property of 2,3-diphenyl-5a-(1-hydroxyethyl)-4a,5a,6,7-tetrahydro-5H-cyclopropaimidazo<1,2-a>pyrimidine-4a-carboxylic acid lactone

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Technology Process of 2,3-diphenyl-5a-(1-hydroxyethyl)-4a,5a,6,7-tetrahydro-5H-cyclopropaimidazo<1,2-a>pyrimidine-4a-carboxylic acid lactone

There total 10 articles about 2,3-diphenyl-5a-(1-hydroxyethyl)-4a,5a,6,7-tetrahydro-5H-cyclopropaimidazo<1,2-a>pyrimidine-4a-carboxylic acid lactone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.3%

: 82874-62-2
ethyl 2,3-diphenyl-5a-(1-hydroxyethyl)-4a,5a,6,7-tetrahydro-5H-cyclopropaimidazo<1,2-a>pyrimidine-4a-carboxylate

: 82874-63-3
2,3-diphenyl-5a-(1-hydroxyethyl)-4a,5a,6,7-tetrahydro-5H-cyclopropaimidazo<1,2-a>pyrimidine-4a-carboxylic acid lactone

Guidance literature:: In xylene; for 20h; Heating;

Reference yield:

: 82874-51-9
ethyl (4aR*,5aR*,6S*)-5a-Acetyl-2,3-diphenyl-6-methoxy-4a,5a,6,7-tetrahydro-5H-cyclopropaimidazo<1,2-a>pyrimidine-4a-carboxylate

: 82874-63-3
2,3-diphenyl-5a-(1-hydroxyethyl)-4a,5a,6,7-tetrahydro-5H-cyclopropaimidazo<1,2-a>pyrimidine-4a-carboxylic acid lactone

Guidance literature:: Multi-step reaction with 4 steps

1: 47.1 percent / conc. HCl / ethanol / 24 h / Heating

2: 50 percent / K₂CO₃ / acetone / 2 h / Heating

3: 53.9 percent / NaBH₄ / ethanol / 1 h

4: 85.3 percent / xylene / 20 h / Heating

With hydrogenchloride; sodium tetrahydroborate; potassium carbonate; In ethanol; acetone; xylene;

Reference yield:

: 37980-29-3
4,5-diphenyl-1H-imidazol-2-amine

: 82874-63-3
2,3-diphenyl-5a-(1-hydroxyethyl)-4a,5a,6,7-tetrahydro-5H-cyclopropaimidazo<1,2-a>pyrimidine-4a-carboxylic acid lactone

Guidance literature:: Multi-step reaction with 5 steps

1: 95.8 percent / ethanol / 2 h

2: 86.4 percent / ethanol / 2 h / Heating

3: 73 percent / diethyl ether / 10 h / 0 °C

4: 53.9 percent / NaBH₄ / ethanol / 1 h

5: 85.3 percent / xylene / 20 h / Heating

With sodium tetrahydroborate; In diethyl ether; ethanol; xylene;