8-[[4-(iminoaminomethyl)phenyl]methoxy]-7,13-dihydro-5,13-dioxo-quinazolino[3,2-a][1,4]benzodiazepine-6(5H)-propanoic acid ethyl ester

Base Information

Chemical Name:8-[[4-(iminoaminomethyl)phenyl]methoxy]-7,13-dihydro-5,13-dioxo-quinazolino[3,2-a][1,4]benzodiazepine-6(5H)-propanoic acid ethyl ester
CAS No.:167854-04-8
Molecular Formula:C₂₉H₂₇N₅O₅
Molecular Weight:525.564
Hs Code.:

8-[[4-(iminoaminomethyl)phenyl]methoxy]-7,13-dihydro-5,13-dioxo-quinazolino[3,2-a][1,4]benzodiazepine-6(5H)-propanoic acid ethyl ester

Synonyms:

Suppliers and Price of 8-[[4-(iminoaminomethyl)phenyl]methoxy]-7,13-dihydro-5,13-dioxo-quinazolino[3,2-a][1,4]benzodiazepine-6(5H)-propanoic acid ethyl ester

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 8-[[4-(iminoaminomethyl)phenyl]methoxy]-7,13-dihydro-5,13-dioxo-quinazolino[3,2-a][1,4]benzodiazepine-6(5H)-propanoic acid ethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 8-[[4-(iminoaminomethyl)phenyl]methoxy]-7,13-dihydro-5,13-dioxo-quinazolino[3,2-a][1,4]benzodiazepine-6(5H)-propanoic acid ethyl ester

There total 15 articles about 8-[[4-(iminoaminomethyl)phenyl]methoxy]-7,13-dihydro-5,13-dioxo-quinazolino[3,2-a][1,4]benzodiazepine-6(5H)-propanoic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 3-[3-(4-methylsulfanylcarbonimidoyl-benzyloxy)-5,13-dioxo-7,13-dihydro-5H-6,8,13a-triaza-benzo[3,4]cyclohepta[1,2-b]naphthalen-6-yl]-propionic acid ethyl ester

: 167854-04-8
8-[[4-(iminoaminomethyl)phenyl]methoxy]-7,13-dihydro-5,13-dioxo-quinazolino[3,2-a][1,4]benzodiazepine-6(5H)-propanoic acid ethyl ester

Guidance literature:: With ammonium acetate; In ethanol; at 50 ℃; for 0.5h;
DOI:10.1016/S0968-0896(98)80013-8

Reference yield:

: 42454-06-8
2-nitro-5-hydroxybenzaldehyde

: 167854-04-8
8-[[4-(iminoaminomethyl)phenyl]methoxy]-7,13-dihydro-5,13-dioxo-quinazolino[3,2-a][1,4]benzodiazepine-6(5H)-propanoic acid ethyl ester

Guidance literature:: Multi-step reaction with 13 steps

1: 175.8 g / potassium carbonate / dimethylformamide / 2.5 h / 50 °C

2: tetrabutylammonium bromide; potassium permanganate / H₂O; pyridine / 20 °C

3: oxalyl chloride / benzene; dimethylformamide / 20 - 65 °C

4: 800 mg / sodium bicarbonate / tetrahydrofuran; H₂O / 18.3 h / 0 - 20 °C

5: 700 mg / tin(II) chloride dihydrate / ethyl acetate; ethanol / 3.5 h / 70 °C

6: 98 percent / CH₂Cl₂; H₂O / 0.67 h / 0 °C

7: 77 percent / potassium carbonate / dimethylformamide / 2 h / 50 °C

8: 96 percent / Lawesson's reagent / tetrahydrofuran / 2 h / 50 °C

9: tetrabutylammonium hydrogen sulfate; sodium hydroxide / CH₂Cl₂; H₂O / 16 h / 20 °C

10: 0.3 g / pyridinium hydrochloride / toluene / 5 h / Heating

11: hydrogen sulfide / pyridine; diethylamine / 3 h / 20 °C

12: CH₂Cl₂ / 0.5 h / 50 °C

13: ammonium acetate / ethanol / 0.5 h / 50 °C

With Lawessons reagent; ammonium acetate; sodium hydroxide; potassium permanganate; oxalyl dichloride; hydrogen sulfide; tetrabutylammomium bromide; tetra(n-butyl)ammonium hydrogensulfate; pyridine hydrochloride; sodium hydrogencarbonate; potassium carbonate; tin(ll) chloride; In tetrahydrofuran; pyridine; ethanol; dichloromethane; water; ethyl acetate; diethylamine; N,N-dimethyl-formamide; toluene; benzene; 1: Etherification / 2: Oxidation / 3: Substitution / 4: Acylation / 5: Reduction / 6: Acylation / 7: Cyclization / 8: Substitution / 9: Methylation / 10: Cyclization / 11: Addition / 12: Methylation / 13: Substitution;
DOI:10.1016/S0968-0896(98)80013-8

Reference yield:

: 4244-84-2
ethyl β-alaninate hydrochloride

: 167854-04-8
8-[[4-(iminoaminomethyl)phenyl]methoxy]-7,13-dihydro-5,13-dioxo-quinazolino[3,2-a][1,4]benzodiazepine-6(5H)-propanoic acid ethyl ester

Guidance literature:: Multi-step reaction with 10 steps

1: 800 mg / sodium bicarbonate / tetrahydrofuran; H₂O / 18.3 h / 0 - 20 °C

2: 700 mg / tin(II) chloride dihydrate / ethyl acetate; ethanol / 3.5 h / 70 °C

3: 98 percent / CH₂Cl₂; H₂O / 0.67 h / 0 °C

4: 77 percent / potassium carbonate / dimethylformamide / 2 h / 50 °C

5: 96 percent / Lawesson's reagent / tetrahydrofuran / 2 h / 50 °C

6: tetrabutylammonium hydrogen sulfate; sodium hydroxide / CH₂Cl₂; H₂O / 16 h / 20 °C

7: 0.3 g / pyridinium hydrochloride / toluene / 5 h / Heating

8: hydrogen sulfide / pyridine; diethylamine / 3 h / 20 °C

9: CH₂Cl₂ / 0.5 h / 50 °C

10: ammonium acetate / ethanol / 0.5 h / 50 °C

With Lawessons reagent; ammonium acetate; sodium hydroxide; hydrogen sulfide; tetra(n-butyl)ammonium hydrogensulfate; pyridine hydrochloride; sodium hydrogencarbonate; potassium carbonate; tin(ll) chloride; In tetrahydrofuran; pyridine; ethanol; dichloromethane; water; ethyl acetate; diethylamine; N,N-dimethyl-formamide; toluene; 1: Acylation / 2: Reduction / 3: Acylation / 4: Cyclization / 5: Substitution / 6: Methylation / 7: Cyclization / 8: Addition / 9: Methylation / 10: Substitution;
DOI:10.1016/S0968-0896(98)80013-8