(S)-3-Amino-N-{3-[(4-oxo-butyl)-(3-phenyl-propionyl)-amino]-propyl}-3-phenyl-propionamide; compound with trifluoro-acetic acid

Base Information

• Chemical Name: (S)-3-Amino-N-{3-[(4-oxo-butyl)-(3-phenyl-propionyl)-amino]-propyl}-3-phenyl-propionamide; compound with trifluoro-acetic acid
• CAS No.: 107199-63-3
• Molecular Formula: C₂HF₃O₂*C₂₅H₃₃N₃O₃
• Molecular Weight: 537.579
• Mol file: 107199-63-3.mol

Synonyms:

Chemical Property of (S)-3-Amino-N-{3-[(4-oxo-butyl)-(3-phenyl-propionyl)-amino]-propyl}-3-phenyl-propionamide; compound with trifluoro-acetic acid

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (S)-3-Amino-N-{3-[(4-oxo-butyl)-(3-phenyl-propionyl)-amino]-propyl}-3-phenyl-propionamide; compound with trifluoro-acetic acid

There total 8 articles about (S)-3-Amino-N-{3-[(4-oxo-butyl)-(3-phenyl-propionyl)-amino]-propyl}-3-phenyl-propionamide; compound with trifluoro-acetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

((S)-2-{3-[(4-Oxo-butyl)-(3-phenyl-propionyl)-amino]-propylcarbamoyl}-1-phenyl-ethyl)-carbamic acid tert-butyl ester (107199-61-1) → (S)-3-Amino-N-{3-[(4-oxo-butyl)-(3-phenyl-propionyl)-amino]-propyl}-3-phenyl-propionamide; compound with trifluoro-acetic acid (107199-63-3)

Guidance literature:

With trifluoroacetic acid;

DOI:10.1016/S0040-4039(00)83978-7

Reference yield:

3-<(4-Hydroxybutyl)amino>propannitril (107199-54-2) → (S)-3-Amino-N-{3-[(4-oxo-butyl)-(3-phenyl-propionyl)-amino]-propyl}-3-phenyl-propionamide; compound with trifluoro-acetic acid (107199-63-3)

Guidance literature:

Multi-step reaction with 6 steps

2: 90 percent / H₂ / platinum oxide

3: 80 percent / 2-chloro-1-methylpyridinium iodide

4: 90 percent / aq. K₂CO₃

5: 70 percent / pyridinium chlorochromate

6: 90 percent / trifluoroacetic acid

With 2-chloro-1-methyl-pyridinium iodide; hydrogen; potassium carbonate; pyridinium chlorochromate; trifluoroacetic acid; platinum(IV) oxide;

DOI:10.1016/S0040-4039(00)83978-7

Reference yield:

(E)-3-Phenyl-acrylic acid 4-{(2-cyano-ethyl)-[(E)-(3-phenyl-acryloyl)]-amino}-butyl ester (107199-58-6) → (S)-3-Amino-N-{3-[(4-oxo-butyl)-(3-phenyl-propionyl)-amino]-propyl}-3-phenyl-propionamide; compound with trifluoro-acetic acid (107199-63-3)

Guidance literature:

Multi-step reaction with 5 steps

1: 90 percent / H₂ / platinum oxide

2: 80 percent / 2-chloro-1-methylpyridinium iodide

3: 90 percent / aq. K₂CO₃

4: 70 percent / pyridinium chlorochromate

5: 90 percent / trifluoroacetic acid

With 2-chloro-1-methyl-pyridinium iodide; hydrogen; potassium carbonate; pyridinium chlorochromate; trifluoroacetic acid; platinum(IV) oxide;

DOI:10.1016/S0040-4039(00)83978-7

upstream raw materials:

((S)-2-{3-[(4-Oxo-butyl)-(3-phenyl-propionyl)-amino]-propylcarbamoyl}-1-phenyl-ethyl)-carbamic acid tert-butyl ester

(S)-3-amino-3-phenylpropanoic acid

3-<(4-Hydroxybutyl)amino>propannitril

(E)-3-Phenyl-acrylic acid 4-{(2-cyano-ethyl)-[(E)-(3-phenyl-acryloyl)]-amino}-butyl ester

Downstream raw materials:

(-)-dihydrocelacinnine