2-[[[(1,1-dimethylethoxy)carbonyl]amino]methyl]-2-ethylbutanoic acid

Base Information

• Chemical Name: 2-[[[(1,1-dimethylethoxy)carbonyl]amino]methyl]-2-ethylbutanoic acid
• CAS No.: 204514-21-6
• Molecular Formula: C₁₂H₂₃NO₄
• Molecular Weight: 245.319

Synonyms:

Chemical Property of 2-[[[(1,1-dimethylethoxy)carbonyl]amino]methyl]-2-ethylbutanoic acid

Chemical Property:

• Boiling Point: 374.3±25.0 °C(Predicted)
• Density: 1.050±0.06 g/cm3(Predicted)

Purity/Quality:

2-({[(Tert-butoxy)carbonyl]amino}methyl)-2-ethylbutanoicacid ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
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MSDS Files:

Useful:

Technology Process of 2-[[[(1,1-dimethylethoxy)carbonyl]amino]methyl]-2-ethylbutanoic acid

There total 5 articles about 2-[[[(1,1-dimethylethoxy)carbonyl]amino]methyl]-2-ethylbutanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

(2-ethyl-2-hydroxymethyl-butyl)-carbamic acid tert-butyl ester (223763-89-1) → 2-[[[(1,1-dimethylethoxy)carbonyl]amino]methyl]-2-ethylbutanoic acid (204514-21-6)

Guidance literature:

With ruthenium trichloride; sodium periodate; In tetrachloromethane; acetonitrile;

DOI:10.1016/S0960-894X(98)00748-3

Reference yield:

ethyl 2-ethyl-2-cyanobutyrate (1619-56-3) → 2-[[[(1,1-dimethylethoxy)carbonyl]amino]methyl]-2-ethylbutanoic acid (204514-21-6)

Guidance literature:

Multi-step reaction with 3 steps

1: H₂ / 5 percent Rh/Al₂O₃

3: NaOH / dioxane

With sodium hydroxide; hydrogen; Rh/Al₂O₃; In 1,4-dioxane; 1: Reduction / 2: Acylation / 3: Hydrolysis;

DOI:10.1016/S0960-894X(00)00174-8

Reference yield:

2-(tert-butoxycarbonylamino-methyl)-2-ethyl-butyric acid ethyl ester → 2-[[[(1,1-dimethylethoxy)carbonyl]amino]methyl]-2-ethylbutanoic acid (204514-21-6)

Guidance literature:

With sodium hydroxide; In 1,4-dioxane;

DOI:10.1016/S0960-894X(00)00174-8

upstream raw materials:

(2-ethyl-2-hydroxymethyl-butyl)-carbamic acid tert-butyl ester

2-ethyl-2-aminomethyl-butyric acid ethyl ester

ethyl 2-ethyl-2-cyanobutyrate

2-(aminomethyl)-2-ethylbutan-1-ol

Downstream raw materials:

(E)-(3S,10R,16S)-16-((1R,2R,3S)-3-Chloro-2-hydroxy-1-methyl-3-phenyl-propyl)-10-(3-chloro-4-methoxy-benzyl)-6,6-diethyl-3-isobutyl-1,4-dioxa-8,11-diaza-cyclohexadec-13-ene-2,5,9,12-tetraone

(E)-(3S,10R,16S)-10-(3-Chloro-4-methoxy-benzyl)-6,6-diethyl-3-isobutyl-16-((E)-(R)-1-methyl-3-phenyl-allyl)-1,4-dioxa-8,11-diaza-cyclohexadec-13-ene-2,5,9,12-tetraone

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