N-(ethoxycarbonylmethyl)-2-phenyl-4-methyl-5-thiazolecarboxamide

Base Information

• Chemical Name: N-(ethoxycarbonylmethyl)-2-phenyl-4-methyl-5-thiazolecarboxamide
• CAS No.: 1384111-09-4
• Molecular Formula: C₁₅H₁₆N₂O₃S
• Molecular Weight: 304.37
• Mol file: 1384111-09-4.mol

Synonyms:

Chemical Property of N-(ethoxycarbonylmethyl)-2-phenyl-4-methyl-5-thiazolecarboxamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-(ethoxycarbonylmethyl)-2-phenyl-4-methyl-5-thiazolecarboxamide

There total 3 articles about N-(ethoxycarbonylmethyl)-2-phenyl-4-methyl-5-thiazolecarboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 63.0%

4-methyl-2-(phenyl)-1,3-thiazol-5-carboxylic acid (33763-20-1) + glycine ethyl ester hydrochloride (623-33-6) → N-(ethoxycarbonylmethyl)-2-phenyl-4-methyl-5-thiazolecarboxamide (1384111-09-4)

Guidance literature:

With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In N,N-dimethyl-formamide; Inert atmosphere;

DOI:10.3987/COM-13-12865

Reference yield:

benzenecarbothioamide (2227-79-4) → N-(ethoxycarbonylmethyl)-2-phenyl-4-methyl-5-thiazolecarboxamide (1384111-09-4)

Guidance literature:

Multi-step reaction with 3 steps

1: ethanol / 2 h / Reflux; Inert atmosphere

2: lithium hydroxide monohydrate / methanol; water / Inert atmosphere

3: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / N,N-dimethyl-formamide / Inert atmosphere

With lithium hydroxide monohydrate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In methanol; ethanol; water; N,N-dimethyl-formamide;

DOI:10.3987/COM-13-12865

Reference yield:

4-methyl-2-phenyl-thiazole-5-carboxylic acid ethyl ester (53715-64-3) → N-(ethoxycarbonylmethyl)-2-phenyl-4-methyl-5-thiazolecarboxamide (1384111-09-4)

Guidance literature:

Multi-step reaction with 2 steps

1: lithium hydroxide monohydrate / methanol; water / Inert atmosphere

2: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / N,N-dimethyl-formamide / Inert atmosphere

With lithium hydroxide monohydrate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In methanol; water; N,N-dimethyl-formamide;

DOI:10.3987/COM-13-12865

upstream raw materials:

4-methyl-2-(phenyl)-1,3-thiazol-5-carboxylic acid

glycine ethyl ester hydrochloride

benzenecarbothioamide

4-methyl-2-phenyl-thiazole-5-carboxylic acid ethyl ester