3-(2-amino-6-(1-((6-(2-hydroxypropan-2-yl)pyridin-2-yl)methyl)-1H-1,2,3-triazol-4-yl)pyrimidin-4-yl)-2-methylbenzonitrile

Base Information

Chemical Name:3-(2-amino-6-(1-((6-(2-hydroxypropan-2-yl)pyridin-2-yl)methyl)-1H-1,2,3-triazol-4-yl)pyrimidin-4-yl)-2-methylbenzonitrile
CAS No.:2239273-34-6
Molecular Formula:C₂₃H₂₂N₈O
Molecular Weight:426.481
Hs Code.:

Synonyms:

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 3-(2-amino-6-(1-((6-(2-hydroxypropan-2-yl)pyridin-2-yl)methyl)-1H-1,2,3-triazol-4-yl)pyrimidin-4-yl)-2-methylbenzonitrile

Chemical Property:

Purity/Quality:: 99%, ^*data from raw suppliers

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Technology Process of 3-(2-amino-6-(1-((6-(2-hydroxypropan-2-yl)pyridin-2-yl)methyl)-1H-1,2,3-triazol-4-yl)pyrimidin-4-yl)-2-methylbenzonitrile

There total 16 articles about 3-(2-amino-6-(1-((6-(2-hydroxypropan-2-yl)pyridin-2-yl)methyl)-1H-1,2,3-triazol-4-yl)pyrimidin-4-yl)-2-methylbenzonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 1202403-01-7
2-(6-(azidomethyl)pyridin-2-yl)propan-2-ol

: 3-(2-amino-6-ethynylpyrimidin-4-yl)-2-methylbenzonitrile

: 2239273-34-6
3-(2-amino-6-(1-((6-(2-hydroxypropan-2-yl)pyridin-2-yl)methyl)-1H-1,2,3-triazol-4-yl)pyrimidin-4-yl)-2-methylbenzonitrile

Guidance literature:: With copper(ll) sulfate pentahydrate; sodium L-ascorbate; In water; tert-butyl alcohol; at 60 ℃; for 13h;

Reference yield:

: 3-(2-amino-6-{2-[tris(propan-2-yl)silyl]ethynyl}-pyrimidin-4-yl)-2-methylbenzonitrile

: 2239273-34-6
3-(2-amino-6-(1-((6-(2-hydroxypropan-2-yl)pyridin-2-yl)methyl)-1H-1,2,3-triazol-4-yl)pyrimidin-4-yl)-2-methylbenzonitrile

Guidance literature:: Multi-step reaction with 2 steps

1: tetrabutyl ammonium fluoride / tetrahydrofuran / 0.25 h / 0 °C

2: copper(ll) sulfate pentahydrate; sodium L-ascorbate / water; tert-butyl alcohol / 13 h / 60 °C

With copper(ll) sulfate pentahydrate; tetrabutyl ammonium fluoride; sodium L-ascorbate; In tetrahydrofuran; water; tert-butyl alcohol;

Reference yield:

: 76006-33-2
3-bromo-2-methylbenzoic acid

: 2239273-34-6
3-(2-amino-6-(1-((6-(2-hydroxypropan-2-yl)pyridin-2-yl)methyl)-1H-1,2,3-triazol-4-yl)pyrimidin-4-yl)-2-methylbenzonitrile

Guidance literature:: Multi-step reaction with 11 steps

1.1: thionyl chloride / N,N-dimethyl-formamide / 20 °C

2.1: ammonium hydroxide / acetonitrile / 20 °C

3.1: thionyl chloride / 20 °C

4.1: TurboGrignard / tetrahydrofuran / 4 h / Inert atmosphere; Cooling with ice

4.2: Cooling with ice

5.1: oxalyl dichloride; N,N-dimethyl-formamide / dichloromethane / Inert atmosphere

6.1: magnesium chloride; triethylamine / acetonitrile / 1 h / -10 °C

6.2: 0.5 h / Cooling with ice

7.1: 2,2,2-trifluoroethanol / 16 h / Inert atmosphere; Reflux

8.1: N-benzyl-N,N,N-triethylammonium chloride; trichlorophosphate / acetonitrile / 4 h / Inert atmosphere; Reflux

9.1: triethylamine; copper(l) iodide; bis-triphenylphosphine-palladium(II) chloride / tetrahydrofuran / 50 °C / Reflux

10.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 0 °C

11.1: sodium L-ascorbate; copper(I) sulfate pentahydrate / water; tetrahydrofuran; tert-butyl methyl ether / 20 h / 60 °C

With bis-triphenylphosphine-palladium(II) chloride; ammonium hydroxide; copper(l) iodide; TurboGrignard; thionyl chloride; oxalyl dichloride; copper(I) sulfate pentahydrate; tetrabutyl ammonium fluoride; N-benzyl-N,N,N-triethylammonium chloride; sodium L-ascorbate; triethylamine; N,N-dimethyl-formamide; magnesium chloride; trichlorophosphate; In tetrahydrofuran; dichloromethane; tert-butyl methyl ether; 2,2,2-trifluoroethanol; water; N,N-dimethyl-formamide; acetonitrile; 9.1: |Sonogashira Cross-Coupling;
DOI:10.1021/acs.oprd.0c00124