Methyl 6-(hydroxymethyl)picolinate

Base Information

Chemical Name:Methyl 6-(hydroxymethyl)picolinate
CAS No.:39977-44-1
Molecular Formula:C8H9NO3
Molecular Weight:167.164
Hs Code.:2933399090
European Community (EC) Number:809-354-8
DSSTox Substance ID:DTXSID80467819
Nikkaji Number:J2.536.171G
Wikidata:Q72491394
Mol file:39977-44-1.mol

Synonyms:methyl 6-(hydroxymethyl)picolinate;39977-44-1;Methyl 6-(hydroxymethyl)pyridine-2-carboxylate;Methyl-6-hydroxymethyl-2-carboxylate pyridine;Methyl 6-(hydroxymethyl)-2-pyridinecarboxylate;MFCD03840850;Methyl 6-hydroxymethyl-2-pyridine carboxylic acid;6-HYDROXYMETHYL-PYRIDINE-2-CARBOXYLIC ACID METHYL ESTER;6-(hydroxymethyl)-2-pyridinecarboxylic acid methyl ester;2-PYRIDINECARBOXYLIC ACID, 6-(HYDROXYMETHYL)-, METHYL ESTER;SCHEMBL183978;methyl 6-hydroxymethylpicolinate;2-Pyridinecarboxylicacid, 6-(hydroxymethyl)-, methyl ester;DTXSID80467819;DVIUNMLAPDJWHL-UHFFFAOYSA-N;AMY30323;AC-610;AR2723;AKOS006277583;AB16738;CS-W013238;DS-14744;SY035403;2-(Hydroxymethyl)-6-methoxycarbonylpyridine;6-(Hydroxymethyl)picolinic acid methyl ester;FT-0686155;methyl 6-hydroxymethylpyridine-2-carboxylate;methyl6-(hydroxymethyl)-2-pyridinecarboxylate;EN300-128737;A824831;J-522689;6-hydroxymethylpyridine-2-carboxylic acid methyl ester;6-Hydroxymethyl-2-pyridinecarboxylic acid, methyl ester;methyl-6-hydroxymethyl-2-carboxylate pyridine, AldrichCPR;methyl 6-(hydroxymethyl)pyridine-2-carboxylate;METHYL 6-(HYDROXYMETHYL)PICOLINATE

Suppliers and Price of Methyl 6-(hydroxymethyl)picolinate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
Methyl6-(Hydroxymethyl)-2-pyridinecarboxylate
1g
$ 165.00

Oakwood
Methyl6-(hydroxymethyl)picolinate 98%
100g
$ 540.00

Oakwood
Methyl6-(hydroxymethyl)picolinate 98%
500g
$ 1620.00

Medical Isotopes, Inc.
Methyl6-(Hydroxymethyl)-2-pyridinecarboxylate
10 g
$ 2200.00

Matrix Scientific
Methyl 6-(hydroxymethyl)picolinate 97%
5g
$ 699.00

Labseeker
6-Hydroxymethyl-pyridine-2-carboxylicacidmethylester 95
25g
$ 615.00

Crysdot
Methyl6-(hydroxymethyl)picolinate 97%
25g
$ 198.00

Chemenu
2-Pyridinecarboxylicacid,6-(hydroxymethyl)-,methylester 95+%
1000g
$ 14080.00

AstaTech
METHYL6-(HYDROXYMETHYL)PICOLINATE 95%
25 / G
$ 209.00

AstaTech
METHYL6-(HYDROXYMETHYL)PICOLINATE 95%
5 / G
$ 74.00

Total 46 raw suppliers

Chemical Property of Methyl 6-(hydroxymethyl)picolinate

Chemical Property:

Vapor Pressure:0mmHg at 25°C
Refractive Index:1.546
Boiling Point:327.251 °C at 760 mmHg
PKA:13.03±0.10(Predicted)
Flash Point:151.716 °C
PSA：59.42000
Density:1.244 g/cm³
LogP:0.36050
Storage Temp.:Inert atmosphere,Room Temperature
XLogP3:0.2
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:3
Exact Mass:167.058243149
Heavy Atom Count:12
Complexity:160

Purity/Quality:

99%, ^*data from raw suppliers

Methyl6-(Hydroxymethyl)-2-pyridinecarboxylate ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:Xi
Statements: 36/37/38
Safety Statements: 26

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:COC(=O)C1=CC=CC(=N1)CO
Uses Methyl 6-(Hydroxymethyl)-2-pyridinecarboxylate is a chemical compound used in the synthesis of Losartan (L470500) derivatives as AT1 antagonists in the preparation of antihypertensive agents. Also used to prepare telomerase inhibitors for in vivo inhibitory activity.

Technology Process of Methyl 6-(hydroxymethyl)picolinate

There total 1 articles about Methyl 6-(hydroxymethyl)picolinate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 51.0%

: 5453-67-8
2,6-bis(methoxycarbonyl)pyridine

: 1195-59-1
2.6-bis(hydroxymethyl)pyridine

: 39977-44-1
methyl 6-(hydroxymethyl)pyridine-2-carboxylate

Guidance literature:: With sodium tetrahydroborate; In methanol; Cooling with ice;
DOI:10.1021/ja3024725

Reference yield: 89.0%

: 39977-44-1
methyl 6-(hydroxymethyl)pyridine-2-carboxylate

: 152983-23-8
phenyl 2,3-di-O-acetyl-4,6-di-O-benzylidene-1-thio-β-D-glucopyranoside

: 1430399-16-8
3-O-acetyl-4,6-O-benzylidene-α-D-glucopyranose-1,2-O-{[(6-methoxycarbonyl)-2-pyridinomethyl]orthoacetate}

Guidance literature:: phenyl 2,3-di-O-acetyl-4,6-di-O-benzylidene-1-thio-β-D-glucopyranoside; With 1-benzenesulfinyl piperidine; trifluoromethylsulfonic anhydride; 2,4,6-tri-tert-butylpyrimidine; In dichloromethane; at -60 ℃; for 0.25h; Inert atmosphere;

With oct-1-ene; In dichloromethane; at -60 ℃; for 0.25h; Inert atmosphere;

methyl 6-(hydroxymethyl)pyridine-2-carboxylate; In dichloromethane; at -78 ℃; for 3h; Inert atmosphere;
DOI:10.1016/j.carres.2013.02.009

Reference yield: 85.0%

: 39977-44-1
methyl 6-(hydroxymethyl)pyridine-2-carboxylate

: 56822-48-1
(2S,3R,4S,5R,6R)-3,4,5-tris(benzyloxy)-6-((benzyloxy)methyl)tetrahydro-2H-pyran-2-yl acetate

: 1430399-03-3
(6-methoxycarbonylpyrid-2-yl)methyl 2,3,4,6-tetra-O-benzyl-α-D-glucopyranoside

Guidance literature:: With trimethylsilyl trifluoromethanesulfonate; In dichloromethane; at -20 ℃; for 22.5h; Inert atmosphere;
DOI:10.1016/j.carres.2013.02.009