5-(2-bromo-4-{(S)-1-[2-(4-carbamimidoyl-phenylcarbamoyl)-acetylamino]-ethyl}-phenoxy)-nicotinic acid acetate

Base Information

Chemical Name:5-(2-bromo-4-{(S)-1-[2-(4-carbamimidoyl-phenylcarbamoyl)-acetylamino]-ethyl}-phenoxy)-nicotinic acid acetate
CAS No.:1100767-30-3
Molecular Formula:C₂H₄O₂*C₂₄H₂₂BrN₅O₅
Molecular Weight:600.426
Hs Code.:

Synonyms:

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Chemical Property of 5-(2-bromo-4-{(S)-1-[2-(4-carbamimidoyl-phenylcarbamoyl)-acetylamino]-ethyl}-phenoxy)-nicotinic acid acetate

Chemical Property:

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Technology Process of 5-(2-bromo-4-{(S)-1-[2-(4-carbamimidoyl-phenylcarbamoyl)-acetylamino]-ethyl}-phenoxy)-nicotinic acid acetate

There total 11 articles about 5-(2-bromo-4-{(S)-1-[2-(4-carbamimidoyl-phenylcarbamoyl)-acetylamino]-ethyl}-phenoxy)-nicotinic acid acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 27.0%

: 1100767-43-8
5-(2-bromo-4-{1-[2-(4-carbamimidoyl-phenylcarbamoyl)-acetylamino]-ethyl}-phenoxy)-nicotinic acid trifluoroacetate

: 631-61-8,92206-38-7
ammonium acetate

: 1100767-30-3
5-(2-bromo-4-{(S)-1-[2-(4-carbamimidoyl-phenylcarbamoyl)-acetylamino]-ethyl}-phenoxy)-nicotinic acid acetate

Guidance literature:: Resolution of racemate;

Reference yield:

: 1100767-21-2
2-[4-cyano-phenylcarbamoyl]-acetic acid

: 1100767-30-3
5-(2-bromo-4-{(S)-1-[2-(4-carbamimidoyl-phenylcarbamoyl)-acetylamino]-ethyl}-phenoxy)-nicotinic acid acetate

Guidance literature:: Multi-step reaction with 5 steps

1.1: 1-hydroxy-7-aza-benzotriazole; N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 48 h / 20 °C

2.1: hydroxylamine hydrochloride; triethylamine / isopropyl alcohol / 4 h / 70 °C

3.1: lithium hydroxide; water / methanol / 20 - 50 °C

3.2: pH 6

4.1: hydrogen; acetic anhydride / palladium 10% on activated carbon / acetic acid / 2.5 h / 20 °C / 750.08 Torr

5.1: Resolution of racemate

With lithium hydroxide; 1-hydroxy-7-aza-benzotriazole; hydroxylamine hydrochloride; water; hydrogen; acetic anhydride; triethylamine; N-ethyl-N,N-diisopropylamine; HATU; palladium 10% on activated carbon; In methanol; acetic acid; N,N-dimethyl-formamide; isopropyl alcohol;

Reference yield:

: 113117-17-2
ethyl 3-[(4-cyanophenyl)amino]-3-oxopropanoate

: 1100767-30-3
5-(2-bromo-4-{(S)-1-[2-(4-carbamimidoyl-phenylcarbamoyl)-acetylamino]-ethyl}-phenoxy)-nicotinic acid acetate

Guidance literature:: Multi-step reaction with 6 steps

1.1: lithium hydroxide; water / methanol / 20 °C

2.1: 1-hydroxy-7-aza-benzotriazole; N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 48 h / 20 °C

3.1: hydroxylamine hydrochloride; triethylamine / isopropyl alcohol / 4 h / 70 °C

4.1: lithium hydroxide; water / methanol / 20 - 50 °C

4.2: pH 6

5.1: hydrogen; acetic anhydride / palladium 10% on activated carbon / acetic acid / 2.5 h / 20 °C / 750.08 Torr

6.1: Resolution of racemate

With lithium hydroxide; 1-hydroxy-7-aza-benzotriazole; hydroxylamine hydrochloride; water; hydrogen; acetic anhydride; triethylamine; N-ethyl-N,N-diisopropylamine; HATU; palladium 10% on activated carbon; In methanol; acetic acid; N,N-dimethyl-formamide; isopropyl alcohol;