5-(2-bromo-4-{1-[2-(4-carbamimidoyl-phenylcarbamoyl)-acetylamino]-ethyl}-phenoxy)-nicotinic acid trifluoroacetate

Base Information

Chemical Name:5-(2-bromo-4-{1-[2-(4-carbamimidoyl-phenylcarbamoyl)-acetylamino]-ethyl}-phenoxy)-nicotinic acid trifluoroacetate
CAS No.:1100767-43-8
Molecular Formula:C₂HF₃O₂*C₂₄H₂₂BrN₅O₅
Molecular Weight:654.397
Hs Code.:

Synonyms:5-(2-bromo-4-{1-[2-(4-carbamimidoyl-phenylcarbamoyl)-acetylamino]-ethyl}-phenoxy)-nicotinic acid trifluoroacetate

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Chemical Property of 5-(2-bromo-4-{1-[2-(4-carbamimidoyl-phenylcarbamoyl)-acetylamino]-ethyl}-phenoxy)-nicotinic acid trifluoroacetate

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Technology Process of 5-(2-bromo-4-{1-[2-(4-carbamimidoyl-phenylcarbamoyl)-acetylamino]-ethyl}-phenoxy)-nicotinic acid trifluoroacetate

There total 10 articles about 5-(2-bromo-4-{1-[2-(4-carbamimidoyl-phenylcarbamoyl)-acetylamino]-ethyl}-phenoxy)-nicotinic acid trifluoroacetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 37.0%

: 1100767-40-5
5-[2-bromo-4-(1-{2-[4-(N-hydroxycarbamimidoyl)-phenylcarbamoyl]-acetylamino}-ethyl)-phenoxy]-nicotinic acid hydrochloride

: 76-05-1
trifluoroacetic acid

: 1100767-43-8
5-(2-bromo-4-{1-[2-(4-carbamimidoyl-phenylcarbamoyl)-acetylamino]-ethyl}-phenoxy)-nicotinic acid trifluoroacetate

Guidance literature:: 5-[2-bromo-4-(1-{2-[4-(N-hydroxycarbamimidoyl)-phenylcarbamoyl]-acetylamino}-ethyl)-phenoxy]-nicotinic acid hydrochloride; With hydrogen; acetic anhydride; palladium 10% on activated carbon; In acetic acid; at 20 ℃; for 2.5h; under 750.075 Torr;

trifluoroacetic acid;

Reference yield:

: 1100767-21-2
2-[4-cyano-phenylcarbamoyl]-acetic acid

: 1100767-43-8
5-(2-bromo-4-{1-[2-(4-carbamimidoyl-phenylcarbamoyl)-acetylamino]-ethyl}-phenoxy)-nicotinic acid trifluoroacetate

Guidance literature:: Multi-step reaction with 4 steps

1.1: 1-hydroxy-7-aza-benzotriazole; N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 48 h / 20 °C

2.1: hydroxylamine hydrochloride; triethylamine / isopropyl alcohol / 4 h / 70 °C

3.1: lithium hydroxide; water / methanol / 20 - 50 °C

3.2: pH 6

4.1: hydrogen; acetic anhydride / palladium 10% on activated carbon / acetic acid / 2.5 h / 20 °C / 750.08 Torr

With lithium hydroxide; 1-hydroxy-7-aza-benzotriazole; hydroxylamine hydrochloride; water; hydrogen; acetic anhydride; triethylamine; N-ethyl-N,N-diisopropylamine; HATU; palladium 10% on activated carbon; In methanol; acetic acid; N,N-dimethyl-formamide; isopropyl alcohol;

Reference yield:

: 113117-17-2
ethyl 3-[(4-cyanophenyl)amino]-3-oxopropanoate

: 1100767-43-8
5-(2-bromo-4-{1-[2-(4-carbamimidoyl-phenylcarbamoyl)-acetylamino]-ethyl}-phenoxy)-nicotinic acid trifluoroacetate

Guidance literature:: Multi-step reaction with 5 steps

1.1: lithium hydroxide; water / methanol / 20 °C

2.1: 1-hydroxy-7-aza-benzotriazole; N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 48 h / 20 °C

3.1: hydroxylamine hydrochloride; triethylamine / isopropyl alcohol / 4 h / 70 °C

4.1: lithium hydroxide; water / methanol / 20 - 50 °C

4.2: pH 6

5.1: hydrogen; acetic anhydride / palladium 10% on activated carbon / acetic acid / 2.5 h / 20 °C / 750.08 Torr

With lithium hydroxide; 1-hydroxy-7-aza-benzotriazole; hydroxylamine hydrochloride; water; hydrogen; acetic anhydride; triethylamine; N-ethyl-N,N-diisopropylamine; HATU; palladium 10% on activated carbon; In methanol; acetic acid; N,N-dimethyl-formamide; isopropyl alcohol;