2-(carboxymethyl)-5-iodobenzoic acid

Base Information

• Chemical Name: 2-(carboxymethyl)-5-iodobenzoic acid
• CAS No.: 423178-18-1
• Molecular Formula: C₉H₇IO₄
• Molecular Weight: 306.057
• Mol file: 423178-18-1.mol

Synonyms:

Chemical Property of 2-(carboxymethyl)-5-iodobenzoic acid

Chemical Property:

• Melting Point: 280 °C
• Boiling Point: 439.3±35.0 °C(Predicted)
• PKA: 3.41±0.36(Predicted)
• Density: 2.020±0.06 g/cm3(Predicted)

Purity/Quality:

98%min ^*data from raw suppliers

2-(carboxymethyl)-5-iodobenzoicacid 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-(carboxymethyl)-5-iodobenzoic acid

There total 4 articles about 2-(carboxymethyl)-5-iodobenzoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

2,5-diiodobenzoic acid (14192-12-2) + ethyl acetoacetate (141-97-9) → 2-(carboxymethyl)-5-iodobenzoic acid (423178-18-1)

Guidance literature:

With 3,5-dinitrobenzoic acid; triphenylstannane; sodium hydrogencarbonate; In toluene; at 95 ℃; for 24h;

Reference yield: 80.0%

2-benzyloxy-7-iodoisoquinoline-1,3(2H,4H)-dione (1092801-73-4) → 2-(carboxymethyl)-5-iodobenzoic acid (423178-18-1)

Guidance literature:

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate; In water; benzene; Reflux;

DOI:10.1021/jm8007085

Reference yield: 73.0%

5-amino-2-(carboxymethyl)benzoic acid (22901-69-5) → 2-(carboxymethyl)-5-iodobenzoic acid (423178-18-1)

Guidance literature:

5-amino-2-(carboxymethyl)benzoic acid; With hydrogen iodide; sodium nitrite; In water; at 5 ℃;

With copper(l) iodide; hydrogen iodide; In water; at 5 ℃;

DOI:10.1021/jm8007085

upstream raw materials:

2,5-diiodobenzoic acid

ethyl acetoacetate

2-benzyloxy-7-iodoisoquinoline-1,3(2H,4H)-dione

5-amino-2-(carboxymethyl)benzoic acid