5-amino-2-(carboxymethyl)benzoic acid

Base Information

• Chemical Name: 5-amino-2-(carboxymethyl)benzoic acid
• CAS No.: 22901-69-5
• Molecular Formula: C₉H₉NO₄
• Molecular Weight: 195.175
• Mol file: 22901-69-5.mol

Synonyms:5-amino-2-(carboxymethyl)benzoic acid

Chemical Property of 5-amino-2-(carboxymethyl)benzoic acid

Chemical Property:

Purity/Quality:

98%min ^*data from raw suppliers

5-amino-2-(carboxymethyl)benzoicacid 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 5-amino-2-(carboxymethyl)benzoic acid

There total 6 articles about 5-amino-2-(carboxymethyl)benzoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.5%

2-(carboxymethyl)-5-nitrobenzoic acid (3898-66-6) → 5-amino-2-(carboxymethyl)benzoic acid (22901-69-5)

Guidance literature:

With palladium 10% on activated carbon; hydrogen; In methanol; at 25 ℃;

DOI:10.1016/j.bmcl.2015.12.014

Reference yield:

Homophthalic acid (89-51-0) → 5-amino-2-(carboxymethyl)benzoic acid (22901-69-5)

Guidance literature:

Multi-step reaction with 2 steps

1: concentrated sulfuric acid; potassium nitrate

2: tin; aqueous hydrochloric acid

With hydrogenchloride; tin; sulfuric acid; potassium nitrate;

Reference yield:

2-chloro-5-nitrobenzoic acid (2516-96-3) → 5-amino-2-(carboxymethyl)benzoic acid (22901-69-5)

Guidance literature:

Multi-step reaction with 3 steps

1: sodium hydride; copper(I) bromide / 3 h / 80 °C / Inert atmosphere

2: sodium hydroxide; water / methanol / 5 h / 25 °C

3: palladium 10% on activated carbon; hydrogen / methanol / 25 °C

With palladium 10% on activated carbon; water; hydrogen; sodium hydride; copper(I) bromide; sodium hydroxide; In methanol;

DOI:10.1016/j.bmcl.2015.12.014

upstream raw materials:

2-(carboxymethyl)-5-nitrobenzoic acid

Homophthalic acid

2-chloro-5-nitrobenzoic acid

ortho-chlorobenzoic acid

Downstream raw materials:

2-carboxymethyl-5-hydroxybenzoic acid

(2-carboxy-4-cyano-phenyl)-acetic acid

7-amino-2-benzyloxyisoquinoline-1,3(2H,4H)-dione

4-chlorohomophthalic acid