<4R-(R*,R*)>-4--2,2-dimethyl-3-oxazolidinecarboxylic acid 1,1-dimethylethyl ester

Base Information

• Chemical Name: <4R-(R*,R*)>-4--2,2-dimethyl-3-oxazolidinecarboxylic acid 1,1-dimethylethyl ester
• CAS No.: 129786-71-6
• Molecular Formula: C₂₀H₂₇NO₄
• Molecular Weight: 345.439

Synonyms:

Chemical Property of <4R-(R*,R*)>-4--2,2-dimethyl-3-oxazolidinecarboxylic acid 1,1-dimethylethyl ester

Chemical Property:

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Technology Process of <4R-(R*,R*)>-4--2,2-dimethyl-3-oxazolidinecarboxylic acid 1,1-dimethylethyl ester

There total 3 articles about <4R-(R*,R*)>-4--2,2-dimethyl-3-oxazolidinecarboxylic acid 1,1-dimethylethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(R)-4-((R)-1-Benzyloxy-3-trimethylsilanyl-prop-2-ynyl)-2,2-dimethyl-oxazolidine-3-carboxylic acid tert-butyl ester → <4R-(R*,R*)>-4--2,2-dimethyl-3-oxazolidinecarboxylic acid 1,1-dimethylethyl ester (129786-71-6)

Guidance literature:

With water; In N,N-dimethyl-formamide; for 0.75h; Yield given; Ambient temperature;

DOI:10.1021/jo00313a015

Reference yield:

benzyl bromide (100-39-0) → <4R-(R*,R*)>-4--2,2-dimethyl-3-oxazolidinecarboxylic acid 1,1-dimethylethyl ester (129786-71-6)

Guidance literature:

Multi-step reaction with 2 steps

1: 1) NaH (50percent in mineral oil) / dimethylformamide / 2 h / Ambient temperature

2: H₂O / dimethylformamide / 0.75 h / Ambient temperature

With water; sodium hydride; In N,N-dimethyl-formamide;

DOI:10.1021/jo00313a015

Reference yield:

(4R)-4-((1R)-1-hydroxy-3-trimethylsilanyl-prop-2-ynyl)-2,2-dimethyl-oxazolidine-3-carboxylic acid tert-butyl ester (129786-70-5) → <4R-(R*,R*)>-4--2,2-dimethyl-3-oxazolidinecarboxylic acid 1,1-dimethylethyl ester (129786-71-6)

Guidance literature:

Multi-step reaction with 2 steps

1: 1) NaH (50percent in mineral oil) / dimethylformamide / 2 h / Ambient temperature

2: H₂O / dimethylformamide / 0.75 h / Ambient temperature

With water; sodium hydride; In N,N-dimethyl-formamide;

DOI:10.1021/jo00313a015

upstream raw materials:

benzyl bromide

(4R)-4-((1R)-1-hydroxy-3-trimethylsilanyl-prop-2-ynyl)-2,2-dimethyl-oxazolidine-3-carboxylic acid tert-butyl ester

Downstream raw materials:

(2S,3R)-4-hydroxy-3-<<(1,1-dimethylethoxy)carbonyl>amino>-2-(phenylmethoxy)butanoic acid phenylmethyl ester

<4R-(R*,S*)>-2,2-dimethyl-4-<(phenylmethoxy)<(phenylmethoxy)carbonyl>methyl>-3-oxazolidinecarboxylic acid 1,1-dimethylethyl ester

(2S,3R)-2-<<(1,1-dimethylethoxy)carbonyl>amino>-3,4-bis(phenylmethoxy)-4-oxobutanoic acid

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