[8-(4-Amino-1-methyl-butylamino)-6-methoxy-5-(3-trifluoromethyl-phenoxy)-quinolin-4-yl]-methanol; compound with 3-carboxy-3-hydroxy-pentanedioic acid

Base Information

Chemical Name:[8-(4-Amino-1-methyl-butylamino)-6-methoxy-5-(3-trifluoromethyl-phenoxy)-quinolin-4-yl]-methanol; compound with 3-carboxy-3-hydroxy-pentanedioic acid
CAS No.:98525-44-1
Molecular Formula:C₆H₈O₇*C₂₃H₂₆F₃N₃O₃
Molecular Weight:641.598
Hs Code.:

[8-(4-Amino-1-methyl-butylamino)-6-methoxy-5-(3-trifluoromethyl-phenoxy)-quinolin-4-yl]-methanol; compound with 3-carboxy-3-hydroxy-pentanedioic acid

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Chemical Property of [8-(4-Amino-1-methyl-butylamino)-6-methoxy-5-(3-trifluoromethyl-phenoxy)-quinolin-4-yl]-methanol; compound with 3-carboxy-3-hydroxy-pentanedioic acid

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Technology Process of [8-(4-Amino-1-methyl-butylamino)-6-methoxy-5-(3-trifluoromethyl-phenoxy)-quinolin-4-yl]-methanol; compound with 3-carboxy-3-hydroxy-pentanedioic acid

There total 6 articles about [8-(4-Amino-1-methyl-butylamino)-6-methoxy-5-(3-trifluoromethyl-phenoxy)-quinolin-4-yl]-methanol; compound with 3-carboxy-3-hydroxy-pentanedioic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 63460-47-9
2-(4-iodopentyl)-1,3-isoindolinedione

: 98525-44-1
[8-(4-Amino-1-methyl-butylamino)-6-methoxy-5-(3-trifluoromethyl-phenoxy)-quinolin-4-yl]-methanol; compound with 3-carboxy-3-hydroxy-pentanedioic acid

Guidance literature:: Multi-step reaction with 2 steps

1: triethylamine / dimethylformamide / 90 °C

2: 1.) hydrazine / 1.) ethanol, 60 deg C, 4 h, 2.) ethanol

With triethylamine; hydrazine; In N,N-dimethyl-formamide;
DOI:10.1021/jm00149a004

Reference yield:

: 82333-37-7
6-methoxy-4-methyl-8-nitro-5-<3-(trifluoromethyl)phenoxy>quinoline

: 98525-44-1
[8-(4-Amino-1-methyl-butylamino)-6-methoxy-5-(3-trifluoromethyl-phenoxy)-quinolin-4-yl]-methanol; compound with 3-carboxy-3-hydroxy-pentanedioic acid

Guidance literature:: Multi-step reaction with 5 steps

1: 81 percent / acetic acid, selenium dioxide / dioxane; acetic anhydride / Heating

2: 88 percent / sodium borohydride / tetrahydrofuran; ethanol / 1 h

3: 2N hydrochloric acid, stannous chloride, tin / tetrahydrofuran; ethanol / 1 h / 5 - 10 °C

4: triethylamine / dimethylformamide / 90 °C

5: 1.) hydrazine / 1.) ethanol, 60 deg C, 4 h, 2.) ethanol

With hydrogenchloride; tin; sodium tetrahydroborate; selenium(IV) oxide; acetic acid; triethylamine; tin(ll) chloride; hydrazine; In tetrahydrofuran; 1,4-dioxane; ethanol; acetic anhydride; N,N-dimethyl-formamide;
DOI:10.1021/jm00149a004

Reference yield:

: [8-Amino-6-methoxy-5-(3-trifluoromethyl-phenoxy)-quinolin-4-yl]-methanol

: 98525-44-1
[8-(4-Amino-1-methyl-butylamino)-6-methoxy-5-(3-trifluoromethyl-phenoxy)-quinolin-4-yl]-methanol; compound with 3-carboxy-3-hydroxy-pentanedioic acid

Guidance literature:: Multi-step reaction with 2 steps

1: triethylamine / dimethylformamide / 90 °C

2: 1.) hydrazine / 1.) ethanol, 60 deg C, 4 h, 2.) ethanol

With triethylamine; hydrazine; In N,N-dimethyl-formamide;
DOI:10.1021/jm00149a004