(13E,15E)-(3S,6S,9R,10R,21S)-3-(3-hydroxybenzyl)-6-isopropyl-10-methoxy-9-methyl-19-oxa-1,4,7,25-tetraazabicyclo[19.3.1]pentacosa-13,15-diene-2,5,8,20-tetraone

Base Information

Chemical Name:(13E,15E)-(3S,6S,9R,10R,21S)-3-(3-hydroxybenzyl)-6-isopropyl-10-methoxy-9-methyl-19-oxa-1,4,7,25-tetraazabicyclo[19.3.1]pentacosa-13,15-diene-2,5,8,20-tetraone
CAS No.:1381808-85-0
Molecular Formula:C₃₂H₄₆N₄O₇
Molecular Weight:598.74
Hs Code.:

(13E,15E)-(3S,6S,9R,10R,21S)-3-(3-hydroxybenzyl)-6-isopropyl-10-methoxy-9-methyl-19-oxa-1,4,7,25-tetraazabicyclo[19.3.1]pentacosa-13,15-diene-2,5,8,20-tetraone

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Chemical Property of (13E,15E)-(3S,6S,9R,10R,21S)-3-(3-hydroxybenzyl)-6-isopropyl-10-methoxy-9-methyl-19-oxa-1,4,7,25-tetraazabicyclo[19.3.1]pentacosa-13,15-diene-2,5,8,20-tetraone

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Technology Process of (13E,15E)-(3S,6S,9R,10R,21S)-3-(3-hydroxybenzyl)-6-isopropyl-10-methoxy-9-methyl-19-oxa-1,4,7,25-tetraazabicyclo[19.3.1]pentacosa-13,15-diene-2,5,8,20-tetraone

There total 13 articles about (13E,15E)-(3S,6S,9R,10R,21S)-3-(3-hydroxybenzyl)-6-isopropyl-10-methoxy-9-methyl-19-oxa-1,4,7,25-tetraazabicyclo[19.3.1]pentacosa-13,15-diene-2,5,8,20-tetraone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1381812-18-5
(2R,3R)-3-methoxy-2-methyl-hept-6-enoic acid

: 1381808-85-0
(13E,15E)-(3S,6S,9R,10R,21S)-3-(3-hydroxybenzyl)-6-isopropyl-10-methoxy-9-methyl-19-oxa-1,4,7,25-tetraazabicyclo[19.3.1]pentacosa-13,15-diene-2,5,8,20-tetraone

Guidance literature:: Multi-step reaction with 3 steps

1.1: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 0.33 h / 0 °C

1.2: 15 h / 20 °C

2.1: Grubbs catalyst first generation / dichloromethane / 36 h / Reflux

3.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 2.5 h / 0 - 20 °C / Inert atmosphere

3.2: Inert atmosphere

With tetrabutyl ammonium fluoride; N-ethyl-N,N-diisopropylamine; HATU; Grubbs catalyst first generation; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;

Reference yield:

: C₄₀H₆₄N₄O₇Si

: 1381808-85-0
(13E,15E)-(3S,6S,9R,10R,21S)-3-(3-hydroxybenzyl)-6-isopropyl-10-methoxy-9-methyl-19-oxa-1,4,7,25-tetraazabicyclo[19.3.1]pentacosa-13,15-diene-2,5,8,20-tetraone

Guidance literature:: Multi-step reaction with 2 steps

1.1: Grubbs catalyst first generation / dichloromethane / 36 h / Reflux

2.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 2.5 h / 0 - 20 °C / Inert atmosphere

2.2: Inert atmosphere

With tetrabutyl ammonium fluoride; Grubbs catalyst first generation; In tetrahydrofuran; dichloromethane;

Reference yield:

: 2100-17-6
4-pentenal

: 1381808-85-0
(13E,15E)-(3S,6S,9R,10R,21S)-3-(3-hydroxybenzyl)-6-isopropyl-10-methoxy-9-methyl-19-oxa-1,4,7,25-tetraazabicyclo[19.3.1]pentacosa-13,15-diene-2,5,8,20-tetraone

Guidance literature:: Multi-step reaction with 6 steps

1.1: triethylamine; calcium hydride; t-butyldimethylsiyl triflate / dichloromethane / 15 h / 20 °C / Inert atmosphere

1.2: 0.5 h / -78 °C / Inert atmosphere

2.1: proton sponge / dichloromethane / 15 h / 20 °C

3.1: water; lithium hydroxide / tetrahydrofuran / 15 h / 60 °C

4.1: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 0.33 h / 0 °C

4.2: 15 h / 20 °C

5.1: Grubbs catalyst first generation / dichloromethane / 36 h / Reflux

6.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 2.5 h / 0 - 20 °C / Inert atmosphere

6.2: Inert atmosphere

With calcium hydride; t-butyldimethylsiyl triflate; tetrabutyl ammonium fluoride; water; triethylamine; N-ethyl-N,N-diisopropylamine; HATU; lithium hydroxide; Grubbs catalyst first generation; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;