Benzyl tetrahydropyridazine-1(2H)-carboxylate

Base Information

Chemical Name:Benzyl tetrahydropyridazine-1(2H)-carboxylate
CAS No.:124072-88-4
Molecular Formula:C12H16N2O2
Molecular Weight:220.271
Hs Code.:
DSSTox Substance ID:DTXSID201225041
Nikkaji Number:J2.790.967A

Synonyms:124072-88-4;Benzyl tetrahydropyridazine-1(2H)-carboxylate;1(2H)-Pyridazinecarboxylic acid, tetrahydro-, phenylmethyl ester;benzyl 1,2-diazinane-1-carboxylate;benzyl diazinane-1-carboxylate;MFCD23378451;1-Cbz-diazinane;1-Cbz-hexahydropyridazine;SCHEMBL7372052;DTXSID201225041;AKOS027255410;AS-71768;SY269227;Benzyltetrahydropyridazine-1(2H)-carboxylate;Phenylmethyl tetrahydro-1(2H)-pyridazinecarboxylate

Suppliers and Price of Benzyl tetrahydropyridazine-1(2H)-carboxylate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

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Chemicals and raw materials
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Total 1 raw suppliers

Chemical Property of Benzyl tetrahydropyridazine-1(2H)-carboxylate

Chemical Property:

XLogP3:1.9
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:3
Exact Mass:220.121177757
Heavy Atom Count:16
Complexity:227

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1CCN(NC1)C(=O)OCC2=CC=CC=C2

Technology Process of Benzyl tetrahydropyridazine-1(2H)-carboxylate

There total 4 articles about Benzyl tetrahydropyridazine-1(2H)-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

: 154972-38-0
benzyl 2-(tert-butoxycarbonyl)hexahydropyridazine-1-carboxylate

: 124072-88-4
tetrahydropyridazine-1-carboxylic acid benzyl ester

Guidance literature:: With trifluoroacetic acid; In dichloromethane; at 20 ℃; Cooling in ice and salt bath;
DOI:10.3987/COM-09-11768

Reference yield:

: 57699-88-4
1-tert-butoxycarbonyl-2-carbobenzyloxyhydrazine

: 124072-88-4
tetrahydropyridazine-1-carboxylic acid benzyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 32 percent / NaH / dimethylformamide / 20 °C

2: TFA / CH₂Cl₂ / 0 - 20 °C

With sodium hydride; trifluoroacetic acid; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/S0968-0896(03)00478-4

Reference yield:

: 501-53-1,94274-21-2
benzyl chloroformate

: 124072-88-4
tetrahydropyridazine-1-carboxylic acid benzyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: TEA / tetrahydrofuran

2: NaH / dimethylformamide

3: HCl / ethyl acetate

With hydrogenchloride; TEA; sodium hydride; In tetrahydrofuran; ethyl acetate; N,N-dimethyl-formamide;
DOI:10.1016/S0040-4039(01)00917-0