(3R,5R,10S)-7-Benzyl-1,6-dioxo-10-(pyridin-2-ylsulfanylcarbonylmethyl)-2,7-diaza-spiro[4.5]decane-2,3-dicarboxylic acid 2-tert-butyl ester 3-ethyl ester

Base Information

Chemical Name:(3R,5R,10S)-7-Benzyl-1,6-dioxo-10-(pyridin-2-ylsulfanylcarbonylmethyl)-2,7-diaza-spiro[4.5]decane-2,3-dicarboxylic acid 2-tert-butyl ester 3-ethyl ester
CAS No.:205116-02-5
Molecular Formula:C₃₀H₃₅N₃O₇S
Molecular Weight:581.69
Hs Code.:

(3R,5R,10S)-7-Benzyl-1,6-dioxo-10-(pyridin-2-ylsulfanylcarbonylmethyl)-2,7-diaza-spiro[4.5]decane-2,3-dicarboxylic acid 2-tert-butyl ester 3-ethyl ester

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Chemical Property of (3R,5R,10S)-7-Benzyl-1,6-dioxo-10-(pyridin-2-ylsulfanylcarbonylmethyl)-2,7-diaza-spiro[4.5]decane-2,3-dicarboxylic acid 2-tert-butyl ester 3-ethyl ester

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Technology Process of (3R,5R,10S)-7-Benzyl-1,6-dioxo-10-(pyridin-2-ylsulfanylcarbonylmethyl)-2,7-diaza-spiro[4.5]decane-2,3-dicarboxylic acid 2-tert-butyl ester 3-ethyl ester

There total 12 articles about (3R,5R,10S)-7-Benzyl-1,6-dioxo-10-(pyridin-2-ylsulfanylcarbonylmethyl)-2,7-diaza-spiro[4.5]decane-2,3-dicarboxylic acid 2-tert-butyl ester 3-ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 98014-77-8
3-(N-benzyl-N-tert-butoxycarbonylamino)propanal

: 205116-02-5
(3R,5R,10S)-7-Benzyl-1,6-dioxo-10-(pyridin-2-ylsulfanylcarbonylmethyl)-2,7-diaza-spiro[4.5]decane-2,3-dicarboxylic acid 2-tert-butyl ester 3-ethyl ester

Guidance literature:: Multi-step reaction with 7 steps

1: 81 percent / Ph₃P

2: n-BuLi

3: 1.) trifluoroacetic acid; 2.) NaHCO₃

4: 95 percent

5: 1.) DIPEA; 2.) hydrogen / 2.) Pd/C / 1.) MeCN; 2.) MeOH

6: aq. LiOH / tetrahydrofuran

7: Ph₃P / acetonitrile

With lithium hydroxide; n-butyllithium; hydrogen; sodium hydrogencarbonate; N-ethyl-N,N-diisopropylamine; triphenylphosphine; trifluoroacetic acid; palladium on activated charcoal; In tetrahydrofuran; acetonitrile;
DOI:10.1016/S0040-4039(98)00019-7

Reference yield:

: 100-52-7
benzaldehyde

: 205116-02-5
(3R,5R,10S)-7-Benzyl-1,6-dioxo-10-(pyridin-2-ylsulfanylcarbonylmethyl)-2,7-diaza-spiro[4.5]decane-2,3-dicarboxylic acid 2-tert-butyl ester 3-ethyl ester

Guidance literature:: Multi-step reaction with 10 steps

1: H₂ / Pd/C

2: DMAP

3: Swern oxidn.

4: 81 percent / Ph₃P

5: n-BuLi

6: 1.) trifluoroacetic acid; 2.) NaHCO₃

7: 95 percent

8: 1.) DIPEA; 2.) hydrogen / 2.) Pd/C / 1.) MeCN; 2.) MeOH

9: aq. LiOH / tetrahydrofuran

10: Ph₃P / acetonitrile

With dmap; lithium hydroxide; n-butyllithium; hydrogen; sodium hydrogencarbonate; N-ethyl-N,N-diisopropylamine; triphenylphosphine; trifluoroacetic acid; palladium on activated charcoal; In tetrahydrofuran; acetonitrile;
DOI:10.1016/S0040-4039(98)00019-7

Reference yield:

: 144978-12-1,128811-48-3,144978-35-8,251924-83-1
1-tert-butyl 2-ethyl (2R)-5-oxopyrrolidine-1,2-dicarboxylate

: 205116-02-5
(3R,5R,10S)-7-Benzyl-1,6-dioxo-10-(pyridin-2-ylsulfanylcarbonylmethyl)-2,7-diaza-spiro[4.5]decane-2,3-dicarboxylic acid 2-tert-butyl ester 3-ethyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: 79 percent / 1.) LiHMDS / tetrahydrofuran

2: 95 percent

3: 1.) DIPEA; 2.) hydrogen / 2.) Pd/C / 1.) MeCN; 2.) MeOH

4: aq. LiOH / tetrahydrofuran

5: Ph₃P / acetonitrile

With lithium hydroxide; hydrogen; N-ethyl-N,N-diisopropylamine; triphenylphosphine; lithium hexamethyldisilazane; palladium on activated charcoal; In tetrahydrofuran; acetonitrile;
DOI:10.1016/S0040-4039(98)00019-7