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(+/-)-(6R,7S)-1-methylene-2,2-dimethyl-7-(phenoxyacetamido)-1-carbacephem-4-carboxylic acid

Base Information Edit
  • Chemical Name:(+/-)-(6R,7S)-1-methylene-2,2-dimethyl-7-(phenoxyacetamido)-1-carbacephem-4-carboxylic acid
  • CAS No.:100367-05-3
  • Molecular Formula:C19H20N2O5
  • Molecular Weight:356.378
  • Hs Code.:
  • Mol file:100367-05-3.mol
(+/-)-(6R,7S)-1-methylene-2,2-dimethyl-7-(phenoxyacetamido)-1-carbacephem-4-carboxylic acid

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Chemical Property of (+/-)-(6R,7S)-1-methylene-2,2-dimethyl-7-(phenoxyacetamido)-1-carbacephem-4-carboxylic acid Edit
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Technology Process of (+/-)-(6R,7S)-1-methylene-2,2-dimethyl-7-(phenoxyacetamido)-1-carbacephem-4-carboxylic acid

There total 10 articles about (+/-)-(6R,7S)-1-methylene-2,2-dimethyl-7-(phenoxyacetamido)-1-carbacephem-4-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:
Guidance literature:
Multi-step reaction with 7 steps
1: benzene / Heating
2: 60 percent / triethylamine / benzene; cyclohexane / 2 h
3: 92 percent / 10percent aq. H2SO4 / acetic acid / 2 h / 50 °C
4: 79 percent / NaH / 1,2-dimethoxy-ethane / 1 h / Ambient temperature
5: H2S (gas), NEt3 / CH2Cl2 / 0.5 h
6: aq. Na2CO3, 1N NaOH / tetrahydrofuran / 3 h
7: NEt3 / H2O; acetone / 1 h / Ambient temperature
With sodium hydroxide; sulfuric acid; hydrogen sulfide; sodium hydride; sodium carbonate; triethylamine; In tetrahydrofuran; 1,2-dimethoxyethane; dichloromethane; cyclohexane; water; acetic acid; acetone; benzene;
DOI:10.1021/jm00155a013
Guidance literature:
Multi-step reaction with 8 steps
1: 87 percent / pyridinium chlorochromate, NaOAc / CH2Cl2 / 2 h
2: benzene / Heating
3: 60 percent / triethylamine / benzene; cyclohexane / 2 h
4: 92 percent / 10percent aq. H2SO4 / acetic acid / 2 h / 50 °C
5: 79 percent / NaH / 1,2-dimethoxy-ethane / 1 h / Ambient temperature
6: H2S (gas), NEt3 / CH2Cl2 / 0.5 h
7: aq. Na2CO3, 1N NaOH / tetrahydrofuran / 3 h
8: NEt3 / H2O; acetone / 1 h / Ambient temperature
With sodium hydroxide; sulfuric acid; hydrogen sulfide; sodium acetate; sodium hydride; sodium carbonate; triethylamine; pyridinium chlorochromate; In tetrahydrofuran; 1,2-dimethoxyethane; dichloromethane; cyclohexane; water; acetic acid; acetone; benzene;
DOI:10.1021/jm00155a013
Guidance literature:
Multi-step reaction with 10 steps
1: diethyl ether
2: 88.3 percent / LiAlH4 / diethyl ether / 2 h / Heating
3: 87 percent / pyridinium chlorochromate, NaOAc / CH2Cl2 / 2 h
4: benzene / Heating
5: 60 percent / triethylamine / benzene; cyclohexane / 2 h
6: 92 percent / 10percent aq. H2SO4 / acetic acid / 2 h / 50 °C
7: 79 percent / NaH / 1,2-dimethoxy-ethane / 1 h / Ambient temperature
8: H2S (gas), NEt3 / CH2Cl2 / 0.5 h
9: aq. Na2CO3, 1N NaOH / tetrahydrofuran / 3 h
10: NEt3 / H2O; acetone / 1 h / Ambient temperature
With sodium hydroxide; lithium aluminium tetrahydride; sulfuric acid; hydrogen sulfide; sodium acetate; sodium hydride; sodium carbonate; triethylamine; pyridinium chlorochromate; In tetrahydrofuran; 1,2-dimethoxyethane; diethyl ether; dichloromethane; cyclohexane; water; acetic acid; acetone; benzene;
DOI:10.1021/jm00155a013
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