2-{4-[(2-acetylamino-4-oxo-3,4,5,6,7,8-hexahydro-pyrido[2,3-d]pyrimidin-6-ylmethyl)-formyl-amino]-benzoylamino}-4-nitro-butyric acid methyl ester

Base Information

• Chemical Name: 2-{4-[(2-acetylamino-4-oxo-3,4,5,6,7,8-hexahydro-pyrido[2,3-d]pyrimidin-6-ylmethyl)-formyl-amino]-benzoylamino}-4-nitro-butyric acid methyl ester
• CAS No.: 245368-87-0
• Molecular Formula: C₂₃H₂₇N₇O₈
• Molecular Weight: 529.509
• Mol file: 245368-87-0.mol

Synonyms:

Chemical Property of 2-{4-[(2-acetylamino-4-oxo-3,4,5,6,7,8-hexahydro-pyrido[2,3-d]pyrimidin-6-ylmethyl)-formyl-amino]-benzoylamino}-4-nitro-butyric acid methyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-{4-[(2-acetylamino-4-oxo-3,4,5,6,7,8-hexahydro-pyrido[2,3-d]pyrimidin-6-ylmethyl)-formyl-amino]-benzoylamino}-4-nitro-butyric acid methyl ester

There total 3 articles about 2-{4-[(2-acetylamino-4-oxo-3,4,5,6,7,8-hexahydro-pyrido[2,3-d]pyrimidin-6-ylmethyl)-formyl-amino]-benzoylamino}-4-nitro-butyric acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

N-[4-[(2-acetamido-4(3H)-oxo-5,6,7,8-tetrahydropyrido[2,3-d]pyrimidin-6-yl)methyl]-formamido]benzoic acid (139375-94-3) + 2-amino-4-nitro-butyric acid methyl ester (245368-86-9) → 2-{4-[(2-acetylamino-4-oxo-3,4,5,6,7,8-hexahydro-pyrido[2,3-d]pyrimidin-6-ylmethyl)-formyl-amino]-benzoylamino}-4-nitro-butyric acid methyl ester (245368-87-0)

Guidance literature:

With triethylamine; isobutyl chloroformate; In N,N-dimethyl-formamide; at 20 ℃; for 20h;

Reference yield:

methyl Nα-benzyloxycarbonylamino-γ-nitrobutyrate (81546-71-6) → 2-{4-[(2-acetylamino-4-oxo-3,4,5,6,7,8-hexahydro-pyrido[2,3-d]pyrimidin-6-ylmethyl)-formyl-amino]-benzoylamino}-4-nitro-butyric acid methyl ester (245368-87-0)

Guidance literature:

Multi-step reaction with 2 steps

1: 19 percent / HBr / acetic acid / 0.5 h / 20 °C

2: Et₃N; isobutyl chloroformate / dimethylformamide / 20 h / 20 °C

With hydrogen bromide; triethylamine; isobutyl chloroformate; In acetic acid; N,N-dimethyl-formamide; 1: Hydrolysis / 2: Condensation;

Reference yield:

2-<(benzyloxycarbonyl)amino>-4-bromobutanoic acid methyl ester (76338-91-5) → 2-{4-[(2-acetylamino-4-oxo-3,4,5,6,7,8-hexahydro-pyrido[2,3-d]pyrimidin-6-ylmethyl)-formyl-amino]-benzoylamino}-4-nitro-butyric acid methyl ester (245368-87-0)

Guidance literature:

Multi-step reaction with 3 steps

1: 32 percent / NaNO₂ / dimethylsulfoxide / 20 h / 20 °C

2: 19 percent / HBr / acetic acid / 0.5 h / 20 °C

3: Et₃N; isobutyl chloroformate / dimethylformamide / 20 h / 20 °C

With hydrogen bromide; triethylamine; sodium nitrite; isobutyl chloroformate; In acetic acid; dimethyl sulfoxide; N,N-dimethyl-formamide; 1: Substitution / 2: Hydrolysis / 3: Condensation;

upstream raw materials:

N-[4-[(2-acetamido-4(3H)-oxo-5,6,7,8-tetrahydropyrido[2,3-d]pyrimidin-6-yl)methyl]-formamido]benzoic acid

2-amino-4-nitro-butyric acid methyl ester

methyl N^α-benzyloxycarbonylamino-γ-nitrobutyrate

2-<(benzyloxycarbonyl)amino>-4-bromobutanoic acid methyl ester