3-Benzyloxycarbonyl-5-(3-methansulfonyloxypropyl)-8-<2-methoxy-4-(N,N-dimethylamino)-phenyl>-1,2,4,5,6,7,8,9-octahydro-3H-azecino<5,4-b>indol-8-carbonsaeuremethylester

Base Information

Chemical Name:3-Benzyloxycarbonyl-5-(3-methansulfonyloxypropyl)-8-<2-methoxy-4-(N,N-dimethylamino)-phenyl>-1,2,4,5,6,7,8,9-octahydro-3H-azecino<5,4-b>indol-8-carbonsaeuremethylester
CAS No.:129112-73-8
Molecular Formula:C₃₈H₄₇N₃O₈S
Molecular Weight:705.872
Hs Code.:

3-Benzyloxycarbonyl-5-(3-methansulfonyloxypropyl)-8-<2-methoxy-4-(N,N-dimethylamino)-phenyl>-1,2,4,5,6,7,8,9-octahydro-3H-azecino<5,4-b>indol-8-carbonsaeuremethylester

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Chemical Property of 3-Benzyloxycarbonyl-5-(3-methansulfonyloxypropyl)-8-<2-methoxy-4-(N,N-dimethylamino)-phenyl>-1,2,4,5,6,7,8,9-octahydro-3H-azecino<5,4-b>indol-8-carbonsaeuremethylester

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Technology Process of 3-Benzyloxycarbonyl-5-(3-methansulfonyloxypropyl)-8-<2-methoxy-4-(N,N-dimethylamino)-phenyl>-1,2,4,5,6,7,8,9-octahydro-3H-azecino<5,4-b>indol-8-carbonsaeuremethylester

There total 9 articles about 3-Benzyloxycarbonyl-5-(3-methansulfonyloxypropyl)-8-<2-methoxy-4-(N,N-dimethylamino)-phenyl>-1,2,4,5,6,7,8,9-octahydro-3H-azecino<5,4-b>indol-8-carbonsaeuremethylester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

: 129112-72-7,129172-76-5
3-Benzyloxycarbonyl-5-(3-hydroxypropyl)-8-<2-methoxy-4-(N,N-dimethylamino)-phenyl>-1,2,4,5,6,7,8,9-octahydro-3H-azecino<5,4-b>-indol-8-carbonsaeuremethylester

: 124-63-0
methanesulfonyl chloride

: 129112-73-8,129172-77-6
3-Benzyloxycarbonyl-5-(3-methansulfonyloxypropyl)-8-<2-methoxy-4-(N,N-dimethylamino)-phenyl>-1,2,4,5,6,7,8,9-octahydro-3H-azecino<5,4-b>indol-8-carbonsaeuremethylester

Guidance literature:: triethylamine; In dichloromethane; at 0 ℃; for 0.0833333h;
DOI:10.1016/S0040-4020(01)86687-4

Reference yield:

: 15799-79-8
3-methoxy-N,N-dimethylaniline

: 129112-73-8,129172-77-6
3-Benzyloxycarbonyl-5-(3-methansulfonyloxypropyl)-8-<2-methoxy-4-(N,N-dimethylamino)-phenyl>-1,2,4,5,6,7,8,9-octahydro-3H-azecino<5,4-b>indol-8-carbonsaeuremethylester

Guidance literature:: Multi-step reaction with 4 steps

1: 1.) tert.-butylhypochlorite; 2.) boron trifluoride-etherate / 1.) triethylamine / 0 deg C; 1.) dichloromethane, tetrachloromethane; 2.) 1h

2: 80 percent / hydrogen / Pd/C / propan-2-ol / 40 °C

3: 2.) 15percent potassium carbonate / 1.) acetyl chloride, 114h, reflux; 2.) dichloromethane, 10 min

4: 93 percent / triethylamine / CH₂Cl₂ / 0.08 h / 0 °C

With tert-butylhypochlorite; boron trifluoride diethyl etherate; hydrogen; potassium carbonate; palladium on activated charcoal; triethylamine; In dichloromethane; isopropyl alcohol;
DOI:10.1016/S0040-4020(01)86687-4

Reference yield:

: 501-53-1,94274-21-2
benzyl chloroformate

: 129112-73-8,129172-77-6
3-Benzyloxycarbonyl-5-(3-methansulfonyloxypropyl)-8-<2-methoxy-4-(N,N-dimethylamino)-phenyl>-1,2,4,5,6,7,8,9-octahydro-3H-azecino<5,4-b>indol-8-carbonsaeuremethylester

Guidance literature:: Multi-step reaction with 2 steps

1: 2.) 15percent potassium carbonate / 1.) acetyl chloride, 114h, reflux; 2.) dichloromethane, 10 min

2: 93 percent / triethylamine / CH₂Cl₂ / 0.08 h / 0 °C

With potassium carbonate; triethylamine; In dichloromethane;
DOI:10.1016/S0040-4020(01)86687-4