2,2-Dimethyl-butyric acid (1S,2S,3S,6R)-2-[2-((2R,4R,6S)-4-hydroxy-6-hydroxymethyl-tetrahydro-pyran-2-yl)-ethyl]-3-methyl-6-propyl-cyclohexylmethyl ester

Base Information

Chemical Name:2,2-Dimethyl-butyric acid (1S,2S,3S,6R)-2-[2-((2R,4R,6S)-4-hydroxy-6-hydroxymethyl-tetrahydro-pyran-2-yl)-ethyl]-3-methyl-6-propyl-cyclohexylmethyl ester
CAS No.:156741-16-1
Molecular Formula:C₂₅H₄₆O₅
Molecular Weight:426.637
Hs Code.:

2,2-Dimethyl-butyric acid (1S,2S,3S,6R)-2-[2-((2R,4R,6S)-4-hydroxy-6-hydroxymethyl-tetrahydro-pyran-2-yl)-ethyl]-3-methyl-6-propyl-cyclohexylmethyl ester

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Chemical Property of 2,2-Dimethyl-butyric acid (1S,2S,3S,6R)-2-[2-((2R,4R,6S)-4-hydroxy-6-hydroxymethyl-tetrahydro-pyran-2-yl)-ethyl]-3-methyl-6-propyl-cyclohexylmethyl ester

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Technology Process of 2,2-Dimethyl-butyric acid (1S,2S,3S,6R)-2-[2-((2R,4R,6S)-4-hydroxy-6-hydroxymethyl-tetrahydro-pyran-2-yl)-ethyl]-3-methyl-6-propyl-cyclohexylmethyl ester

There total 7 articles about 2,2-Dimethyl-butyric acid (1S,2S,3S,6R)-2-[2-((2R,4R,6S)-4-hydroxy-6-hydroxymethyl-tetrahydro-pyran-2-yl)-ethyl]-3-methyl-6-propyl-cyclohexylmethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 53716-84-0
(1S,3S,5R)-6,8-dioxabicyclo[3.2.1]octan-3-yl acetate

: 156741-16-1
2,2-Dimethyl-butyric acid (1S,2S,3S,6R)-2-[2-((2R,4R,6S)-4-hydroxy-6-hydroxymethyl-tetrahydro-pyran-2-yl)-ethyl]-3-methyl-6-propyl-cyclohexylmethyl ester

Guidance literature:: Multi-step reaction with 6 steps

1: BF₃*Et₂O

2: MeONa

3: ImH / dimethylformamide

4: lithium 4,4'-di-tert-butylbiphenyl / tetrahydrofuran / -78 °C

5: 1.) NaH, CS₂, 2.) MeI, 3.) Bu₃SnH / 2.) THF

6: aq. HF / acetonitrile

With 1H-imidazole; carbon disulfide; boron trifluoride diethyl etherate; hydrogen fluoride; tri-n-butyl-tin hydride; sodium methylate; sodium hydride; lithium 4,4′-di-tert-butylbiphenylide; methyl iodide; In tetrahydrofuran; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1016/S0040-4039(00)75798-4

Reference yield:

: (2S,4S)-2-Hydroxymethyl-6-phenylsulfanyl-tetrahydro-pyran-4-ol

: 156741-16-1
2,2-Dimethyl-butyric acid (1S,2S,3S,6R)-2-[2-((2R,4R,6S)-4-hydroxy-6-hydroxymethyl-tetrahydro-pyran-2-yl)-ethyl]-3-methyl-6-propyl-cyclohexylmethyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: ImH / dimethylformamide

2: lithium 4,4'-di-tert-butylbiphenyl / tetrahydrofuran / -78 °C

3: 1.) NaH, CS₂, 2.) MeI, 3.) Bu₃SnH / 2.) THF

4: aq. HF / acetonitrile

With 1H-imidazole; carbon disulfide; hydrogen fluoride; tri-n-butyl-tin hydride; sodium hydride; lithium 4,4′-di-tert-butylbiphenylide; methyl iodide; In tetrahydrofuran; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1016/S0040-4039(00)75798-4

Reference yield:

: (4S,6S)-2-Phenylsulfanyl-4-trimethylsilanyloxy-6-trimethylsilanyloxymethyl-tetrahydro-pyran

: 156741-16-1
2,2-Dimethyl-butyric acid (1S,2S,3S,6R)-2-[2-((2R,4R,6S)-4-hydroxy-6-hydroxymethyl-tetrahydro-pyran-2-yl)-ethyl]-3-methyl-6-propyl-cyclohexylmethyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: lithium 4,4'-di-tert-butylbiphenyl / tetrahydrofuran / -78 °C

2: 1.) NaH, CS₂, 2.) MeI, 3.) Bu₃SnH / 2.) THF

3: aq. HF / acetonitrile

With carbon disulfide; hydrogen fluoride; tri-n-butyl-tin hydride; sodium hydride; lithium 4,4′-di-tert-butylbiphenylide; methyl iodide; In tetrahydrofuran; acetonitrile;
DOI:10.1016/S0040-4039(00)75798-4