(1R,3aS,7aR)-4-[2-[(3S,5R)-3,5-Bis-(tert-butyl-dimethyl-silanyloxy)-2-methylene-cyclohex-(Z)-ylidene]-eth-(E)-ylidene]-7a-methyl-1-((E)-(1R,4S)-1,4,5-trimethyl-hex-2-enyl)-octahydro-indene

Base Information

• Chemical Name: (1R,3aS,7aR)-4-[2-[(3S,5R)-3,5-Bis-(tert-butyl-dimethyl-silanyloxy)-2-methylene-cyclohex-(Z)-ylidene]-eth-(E)-ylidene]-7a-methyl-1-((E)-(1R,4S)-1,4,5-trimethyl-hex-2-enyl)-octahydro-indene
• CAS No.: 125136-23-4
• Molecular Formula: C₄₀H₇₂O₂Si₂
• Molecular Weight: 641.181
• Mol file: 125136-23-4.mol

Synonyms:

Chemical Property of (1R,3aS,7aR)-4-[2-[(3S,5R)-3,5-Bis-(tert-butyl-dimethyl-silanyloxy)-2-methylene-cyclohex-(Z)-ylidene]-eth-(E)-ylidene]-7a-methyl-1-((E)-(1R,4S)-1,4,5-trimethyl-hex-2-enyl)-octahydro-indene

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (1R,3aS,7aR)-4-[2-[(3S,5R)-3,5-Bis-(tert-butyl-dimethyl-silanyloxy)-2-methylene-cyclohex-(Z)-ylidene]-eth-(E)-ylidene]-7a-methyl-1-((E)-(1R,4S)-1,4,5-trimethyl-hex-2-enyl)-octahydro-indene

There total 25 articles about (1R,3aS,7aR)-4-[2-[(3S,5R)-3,5-Bis-(tert-butyl-dimethyl-silanyloxy)-2-methylene-cyclohex-(Z)-ylidene]-eth-(E)-ylidene]-7a-methyl-1-((E)-(1R,4S)-1,4,5-trimethyl-hex-2-enyl)-octahydro-indene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 50.0%

(2S,5S)-2-{(1R,3aS,7aR)-4-[2-[(3S,5R)-3,5-Bis-(tert-butyl-dimethyl-silanyloxy)-2-methylene-cyclohex-(Z)-ylidene]-eth-(E)-ylidene]-7a-methyl-octahydro-inden-1-yl}-5,6-dimethyl-4-(toluene-4-sulfonyl)-heptan-3-ol (125091-81-8) → (1R,3aS,7aR)-4-[2-[(3S,5R)-3,5-Bis-(tert-butyl-dimethyl-silanyloxy)-2-methylene-cyclohex-(Z)-ylidene]-eth-(E)-ylidene]-7a-methyl-1-((E)-(1R,4S)-1,4,5-trimethyl-hex-2-enyl)-octahydro-indene (125136-23-4,184851-16-9)

Guidance literature:

With sodium amalgam; In tetrahydrofuran; methanol;

DOI:10.1039/c39890001113

Reference yield: 35.0%

1(S),3(R)-3-(tert-butyldimethylsilyl)-9,10-secoergosta-5(E),7(E),10(19),22(E)-tetraene-1-ol (115540-27-7,132152-22-8,112670-78-7) + tert-butyldimethylsilyl chloride (18162-48-6) → 1(S),3(R)-bis(tert-butyldimethylsilyloxy)-9,10-secoergosta-5(E),7(E),10(19),22(E)-tetraene (115540-28-8,125136-23-4,111594-58-2,184851-16-9)

Guidance literature:

With 1H-imidazole; In N,N-dimethyl-formamide; at 20 ℃;

DOI:10.1016/S0040-4039(00)95364-4

Reference yield:

tert-butyldimethylsilyl chloride (18162-48-6) + 1(S),3(R)-3-(tert-butyldimethylsilyl)-9,10-secoergosta-5(E),7(E),10(19),22(E)-tetraene-1-ol (112670-78-7,115540-27-7,132152-22-8) → 1(S),3(R)-bis(tert-butyldimethylsilyloxy)-9,10-secoergosta-5(E),7(E),10(19),22(E)-tetraene (115540-28-8,125136-23-4,111594-58-2,184851-16-9)

Guidance literature:

With 1H-imidazole; In dichloromethane; for 6h; Yield given; Ambient temperature;

DOI:10.1021/jo00058a034

upstream raw materials:

Calciferol

(S)-3-[(1R,3aS,7aR)-7a-Methyl-1-((E)-(1R,4R)-1,4,5-trimethyl-hex-2-enyl)-octahydro-inden-(4E)-ylidenemethyl]-2,2-dioxo-2,3,4,5,6,7-hexahydro-1H-2λ⁶-benzo[c]thiophen-5-ol

tert-butyldimethylsilyl chloride

SO2-adduct of 3(S)-<(tert-butyldimethylsilyl)oxy>-9,10-secoergosta-5,7(E),10(19),22(E)-tetraene

Downstream raw materials:

C₄₀H₇₂O₂Si₂

(24S)-1α-hydroxyvitamin D2

1(S),3(R)-bis(tert-butyldimethylsilyloxy)-20(R)-(3′-isopropyl-3′-oxypropyl)-9,10-secopregna-5(E),7(E),10(19)-triene

(6S)- and (6R)-SO₂ adducts of 1(S),3(R)-bis(tert-butyldimethylsilyloxy)-20(S)-formyl-9,10-secopregna-5,7(E),10⁽¹⁹⁾-triene