Technology Process of 14-<(benzyloxy)methyl>didemnoline A
There total 6 articles about 14-<(benzyloxy)methyl>didemnoline A which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
Multi-step reaction with 3 steps
1: 1.) KOH, 2.) HCl / 1.) water, 1 h, 2.) water, heating
2: 15 percent / S8 / xylene / 4 h / 128 °C
3: 1.) KOH / 1.) DMSO, room temperature, 2 h, 2.) DMSO, overnight
With
hydrogenchloride; sulfur; potassium hydroxide;
In
xylene;
DOI:10.1016/S0040-4020(98)01100-4
- Guidance literature:
-
Multi-step reaction with 3 steps
1: 100 percent / NaBH4 / methanol / 0.25 h
2: 98 percent / SOCl2 / 0.25 h / Heating
3: 1.) KOH / 1.) DMSO, room temperature, 2 h, 2.) DMSO, overnight
With
potassium hydroxide; sodium tetrahydroborate; thionyl chloride;
In
methanol;
DOI:10.1016/S0040-4020(98)01100-4
- Guidance literature:
-
Multi-step reaction with 4 steps
1: 73 percent / NaBH4, BF3*OEt2 / tetrahydrofuran / 2 h / Heating
2: 1.) KOH, 2.) HCl / 1.) water, 1 h, 2.) water, heating
3: 15 percent / S8 / xylene / 4 h / 128 °C
4: 1.) KOH / 1.) DMSO, room temperature, 2 h, 2.) DMSO, overnight
With
hydrogenchloride; sulfur; potassium hydroxide; sodium tetrahydroborate; boron trifluoride diethyl etherate;
In
tetrahydrofuran; xylene;
DOI:10.1016/S0040-4020(98)01100-4
