Technology Process of 1,1'-(2,4,6-trihydroxy-5-((2-oxoazepan-1-yl)methyl)-1,3-phenylene)diethanone
There total 2 articles about 1,1'-(2,4,6-trihydroxy-5-((2-oxoazepan-1-yl)methyl)-1,3-phenylene)diethanone which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Multi-step reaction with 2 steps
1: boron trifluoride diethyl etherate / 2.5 h / 100 °C
2: perchloric acid adsorbed on silica gel / acetonitrile / 7 h / 80 °C
With
perchloric acid adsorbed on silica gel; boron trifluoride diethyl etherate;
In
acetonitrile;
2: |Mannich Aminomethylation;
DOI:10.1021/jo3017132
- Guidance literature:
-
Multi-step reaction with 2 steps
1: perchloric acid adsorbed on silica gel / acetonitrile / 2 h / 80 °C
2: perchloric acid adsorbed on silica gel / acetonitrile / 7 h / 80 °C
With
perchloric acid adsorbed on silica gel;
In
acetonitrile;
2: |Mannich Aminomethylation;
DOI:10.1021/jo3017132
