1-(4-{2-[(1S,2R)-2-{1-[3-(1-methylethyl)-1,2,4-oxadiazol-5-yl]piperidin-4-yl}cyclopropyl]ethoxy}phenyl)imidazolidin-2-one

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Chemical Name:1-(4-{2-[(1S,2R)-2-{1-[3-(1-methylethyl)-1,2,4-oxadiazol-5-yl]piperidin-4-yl}cyclopropyl]ethoxy}phenyl)imidazolidin-2-one
CAS No.:1402551-83-0
Molecular Formula:C₂₄H₃₃N₅O₃
Molecular Weight:439.558
Hs Code.:

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Chemical Property of 1-(4-{2-[(1S,2R)-2-{1-[3-(1-methylethyl)-1,2,4-oxadiazol-5-yl]piperidin-4-yl}cyclopropyl]ethoxy}phenyl)imidazolidin-2-one

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Technology Process of 1-(4-{2-[(1S,2R)-2-{1-[3-(1-methylethyl)-1,2,4-oxadiazol-5-yl]piperidin-4-yl}cyclopropyl]ethoxy}phenyl)imidazolidin-2-one

There total 12 articles about 1-(4-{2-[(1S,2R)-2-{1-[3-(1-methylethyl)-1,2,4-oxadiazol-5-yl]piperidin-4-yl}cyclopropyl]ethoxy}phenyl)imidazolidin-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 287192-97-6
4-ethynyl-piperidine-1-carboxylic acid tert-butyl ester

: 1402551-83-0
1-(4-{2-[(1S,2R)-2-{1-[3-(1-methylethyl)-1,2,4-oxadiazol-5-yl]piperidin-4-yl}cyclopropyl]ethoxy}phenyl)imidazolidin-2-one

Guidance literature:: Multi-step reaction with 10 steps

1.1: n-butyllithium / hexane; tetrahydrofuran / 0.08 h / -78 °C

1.2: 1 h / -78 °C

2.1: hydrogen; quinoline / Lindlars catalyst / ethyl acetate / 0.67 h

3.1: diethylzinc / dichloromethane; diethyl ether / 0.17 h / -20 °C / Inert atmosphere

3.2: 0.17 h

3.3: 24 h / 0 °C

4.1: hydrogen / palladium(II) hydroxide / ethyl acetate; ethanol / 2585.81 Torr

4.2: 0 °C

4.3: 0.5 h / 20 °C

5.1: hydrogenchloride / 1,4-dioxane / 2 h / 20 °C

6.1: sodium hydrogencarbonate / dichloromethane; water / 0.08 h / 0 °C

6.2: 1.5 h / 0 - 20 °C

7.1: ethyl acetate; tetrahydrofuran / Inert atmosphere

7.2: 2 h / 70 °C

7.3: 80 °C

8.1: caesium carbonate / N,N-dimethyl-formamide / 20 °C / Inert atmosphere

9.1: tin(II) chloride dihdyrate / N,N-dimethyl-formamide / 15 h / 20 - 50 °C

10.1: N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 1 h / 20 °C / Inert atmosphere

10.2: 0.5 h / 0 - 20 °C

With quinoline; hydrogenchloride; n-butyllithium; tin(II) chloride dihdyrate; hydrogen; diethylzinc; sodium hydrogencarbonate; caesium carbonate; N-ethyl-N,N-diisopropylamine; palladium(II) hydroxide; In tetrahydrofuran; 1,4-dioxane; diethyl ether; ethanol; hexane; dichloromethane; water; ethyl acetate; N,N-dimethyl-formamide;

Reference yield:

: 1192063-78-7
tert-butyl 4-[(4R)-5-(benzyloxy)-4-hydroxypent-1-yn-1-yl]piperidine-1-carboxylate

: 1402551-83-0
1-(4-{2-[(1S,2R)-2-{1-[3-(1-methylethyl)-1,2,4-oxadiazol-5-yl]piperidin-4-yl}cyclopropyl]ethoxy}phenyl)imidazolidin-2-one

Guidance literature:: Multi-step reaction with 9 steps

1.1: hydrogen; quinoline / Lindlars catalyst / ethyl acetate / 0.67 h

2.1: diethylzinc / dichloromethane; diethyl ether / 0.17 h / -20 °C / Inert atmosphere

2.2: 0.17 h

2.3: 24 h / 0 °C

3.1: hydrogen / palladium(II) hydroxide / ethyl acetate; ethanol / 2585.81 Torr

3.2: 0 °C

3.3: 0.5 h / 20 °C

4.1: hydrogenchloride / 1,4-dioxane / 2 h / 20 °C

5.1: sodium hydrogencarbonate / dichloromethane; water / 0.08 h / 0 °C

5.2: 1.5 h / 0 - 20 °C

6.1: ethyl acetate; tetrahydrofuran / Inert atmosphere

6.2: 2 h / 70 °C

6.3: 80 °C

7.1: caesium carbonate / N,N-dimethyl-formamide / 20 °C / Inert atmosphere

8.1: tin(II) chloride dihdyrate / N,N-dimethyl-formamide / 15 h / 20 - 50 °C

9.1: N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 1 h / 20 °C / Inert atmosphere

9.2: 0.5 h / 0 - 20 °C

With quinoline; hydrogenchloride; tin(II) chloride dihdyrate; hydrogen; diethylzinc; sodium hydrogencarbonate; caesium carbonate; N-ethyl-N,N-diisopropylamine; palladium(II) hydroxide; In tetrahydrofuran; 1,4-dioxane; diethyl ether; ethanol; dichloromethane; water; ethyl acetate; N,N-dimethyl-formamide;

Reference yield:

: tert-butyl 4-[(1Z,4R)-5-(benzyloxy)-4-hydroxypent-1-en-1-yl]piperidine-1-carboxylate

: 1402551-83-0
1-(4-{2-[(1S,2R)-2-{1-[3-(1-methylethyl)-1,2,4-oxadiazol-5-yl]piperidin-4-yl}cyclopropyl]ethoxy}phenyl)imidazolidin-2-one

Guidance literature:: Multi-step reaction with 8 steps

1.1: diethylzinc / dichloromethane; diethyl ether / 0.17 h / -20 °C / Inert atmosphere

1.2: 0.17 h

1.3: 24 h / 0 °C

2.1: hydrogen / palladium(II) hydroxide / ethyl acetate; ethanol / 2585.81 Torr

2.2: 0 °C

2.3: 0.5 h / 20 °C

3.1: hydrogenchloride / 1,4-dioxane / 2 h / 20 °C

4.1: sodium hydrogencarbonate / dichloromethane; water / 0.08 h / 0 °C

4.2: 1.5 h / 0 - 20 °C

5.1: ethyl acetate; tetrahydrofuran / Inert atmosphere

5.2: 2 h / 70 °C

5.3: 80 °C

6.1: caesium carbonate / N,N-dimethyl-formamide / 20 °C / Inert atmosphere

7.1: tin(II) chloride dihdyrate / N,N-dimethyl-formamide / 15 h / 20 - 50 °C

8.1: N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 1 h / 20 °C / Inert atmosphere

8.2: 0.5 h / 0 - 20 °C

With hydrogenchloride; tin(II) chloride dihdyrate; hydrogen; diethylzinc; sodium hydrogencarbonate; caesium carbonate; N-ethyl-N,N-diisopropylamine; palladium(II) hydroxide; In tetrahydrofuran; 1,4-dioxane; diethyl ether; ethanol; dichloromethane; water; ethyl acetate; N,N-dimethyl-formamide;