(2S,4R)-4-(2-((1R,3R)-1-methoxy-4-methyl-3-((2S,3S)-3-methyl-2-((R)-1-methylpiperidine-2-carboxamido)pentanamido)pentyl)thiazole-4-carboxamido)-2-methyl-5-phenylpentanoic acid

Base Information

Chemical Name:(2S,4R)-4-(2-((1R,3R)-1-methoxy-4-methyl-3-((2S,3S)-3-methyl-2-((R)-1-methylpiperidine-2-carboxamido)pentanamido)pentyl)thiazole-4-carboxamido)-2-methyl-5-phenylpentanoic acid
CAS No.:1427513-78-7
Molecular Formula:C₃₆H₅₅N₅O₆S
Molecular Weight:685.929
Hs Code.:

(2S,4R)-4-(2-((1R,3R)-1-methoxy-4-methyl-3-((2S,3S)-3-methyl-2-((R)-1-methylpiperidine-2-carboxamido)pentanamido)pentyl)thiazole-4-carboxamido)-2-methyl-5-phenylpentanoic acid

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Chemical Property of (2S,4R)-4-(2-((1R,3R)-1-methoxy-4-methyl-3-((2S,3S)-3-methyl-2-((R)-1-methylpiperidine-2-carboxamido)pentanamido)pentyl)thiazole-4-carboxamido)-2-methyl-5-phenylpentanoic acid

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Technology Process of (2S,4R)-4-(2-((1R,3R)-1-methoxy-4-methyl-3-((2S,3S)-3-methyl-2-((R)-1-methylpiperidine-2-carboxamido)pentanamido)pentyl)thiazole-4-carboxamido)-2-methyl-5-phenylpentanoic acid

There total 15 articles about (2S,4R)-4-(2-((1R,3R)-1-methoxy-4-methyl-3-((2S,3S)-3-methyl-2-((R)-1-methylpiperidine-2-carboxamido)pentanamido)pentyl)thiazole-4-carboxamido)-2-methyl-5-phenylpentanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1427513-70-9
(2S,4R)-methyl 4-(2-((1R,3R)-1-methoxy-4-methyl-3-((2S,3S)-3-methyl-2-((R)-1-methylpiperidine-2-carboxamido)pentanamido)pentyl)thiazole-4-carboxamido)-2-methyl-5-phenylpentanoate

: 1427513-78-7
(2S,4R)-4-(2-((1R,3R)-1-methoxy-4-methyl-3-((2S,3S)-3-methyl-2-((R)-1-methylpiperidine-2-carboxamido)pentanamido)pentyl)thiazole-4-carboxamido)-2-methyl-5-phenylpentanoic acid

Guidance literature:: With lithium hydroxide; In tetrahydrofuran; water; at 0 - 20 ℃; for 72h; Inert atmosphere;
DOI:10.1039/c3ob27111k

Reference yield:

: (1R,3R)-2-(3-tert-butoxycarbonylamino-1-hydroxy-4-methylpentyl)thiazole-4-carboxylic acid ethyl ester

: 1427513-78-7
(2S,4R)-4-(2-((1R,3R)-1-methoxy-4-methyl-3-((2S,3S)-3-methyl-2-((R)-1-methylpiperidine-2-carboxamido)pentanamido)pentyl)thiazole-4-carboxamido)-2-methyl-5-phenylpentanoic acid

Guidance literature:: Multi-step reaction with 10 steps

1.1: potassium tert-butylate / tetrahydrofuran / 0.25 h / -78 °C / Inert atmosphere

1.2: 1 h / -78 °C / Inert atmosphere

2.1: dichloromethane / 1 h / 0 - 20 °C / Inert atmosphere

3.1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine / dichloromethane / 3 h / 0 - 20 °C

4.1: hydrogenchloride; sodium hydrogencarbonate / water

5.1: lithium hydroxide monohydrate / water; tetrahydrofuran / 5 h / 0 - 20 °C / Inert atmosphere

6.1: triethylamine; 1-hydroxy-7-aza-benzotriazole; HATU / dichloromethane / 3 h / 0 - 20 °C / Inert atmosphere

7.1: dichloromethane / 1 h / 0 - 20 °C / Inert atmosphere

8.1: triethylamine; 1-hydroxy-7-aza-benzotriazole; HATU / dichloromethane / 3 h / 0 - 20 °C / Inert atmosphere

9.1: hydrogenchloride; sodium hydrogencarbonate / water

10.1: lithium hydroxide / water; tetrahydrofuran / 72 h / 0 - 20 °C / Inert atmosphere

With hydrogenchloride; 1-hydroxy-7-aza-benzotriazole; lithium hydroxide monohydrate; potassium tert-butylate; sodium hydrogencarbonate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; N-ethyl-N,N-diisopropylamine; HATU; lithium hydroxide; In tetrahydrofuran; dichloromethane; water;
DOI:10.1039/c3ob27111k

Reference yield:

: C₂₄H₄₁N₃O₆S*C₂HF₃O₂

: 1427513-78-7
(2S,4R)-4-(2-((1R,3R)-1-methoxy-4-methyl-3-((2S,3S)-3-methyl-2-((R)-1-methylpiperidine-2-carboxamido)pentanamido)pentyl)thiazole-4-carboxamido)-2-methyl-5-phenylpentanoic acid

Guidance literature:: Multi-step reaction with 7 steps

1: hydrogenchloride; sodium hydrogencarbonate / water

2: lithium hydroxide monohydrate / water; tetrahydrofuran / 5 h / 0 - 20 °C / Inert atmosphere

3: triethylamine; 1-hydroxy-7-aza-benzotriazole; HATU / dichloromethane / 3 h / 0 - 20 °C / Inert atmosphere

4: dichloromethane / 1 h / 0 - 20 °C / Inert atmosphere

5: triethylamine; 1-hydroxy-7-aza-benzotriazole; HATU / dichloromethane / 3 h / 0 - 20 °C / Inert atmosphere

6: hydrogenchloride; sodium hydrogencarbonate / water

7: lithium hydroxide / water; tetrahydrofuran / 72 h / 0 - 20 °C / Inert atmosphere

With hydrogenchloride; 1-hydroxy-7-aza-benzotriazole; lithium hydroxide monohydrate; sodium hydrogencarbonate; triethylamine; HATU; lithium hydroxide; In tetrahydrofuran; dichloromethane; water;
DOI:10.1039/c3ob27111k