(2S,4R)-methyl 4-(2-((1R,3R)-1-methoxy-4-methyl-3-((2S,3S)-3-methyl-2-((R)-1-methylpiperidine-2-carboxamido)pentanamido)pentyl)thiazole-4-carboxamido)-2-methyl-5-phenylpentanoate

Base Information

Chemical Name:(2S,4R)-methyl 4-(2-((1R,3R)-1-methoxy-4-methyl-3-((2S,3S)-3-methyl-2-((R)-1-methylpiperidine-2-carboxamido)pentanamido)pentyl)thiazole-4-carboxamido)-2-methyl-5-phenylpentanoate
CAS No.:1427513-70-9
Molecular Formula:C₃₇H₅₇N₅O₆S
Molecular Weight:699.955
Hs Code.:

(2S,4R)-methyl 4-(2-((1R,3R)-1-methoxy-4-methyl-3-((2S,3S)-3-methyl-2-((R)-1-methylpiperidine-2-carboxamido)pentanamido)pentyl)thiazole-4-carboxamido)-2-methyl-5-phenylpentanoate

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Chemical Property of (2S,4R)-methyl 4-(2-((1R,3R)-1-methoxy-4-methyl-3-((2S,3S)-3-methyl-2-((R)-1-methylpiperidine-2-carboxamido)pentanamido)pentyl)thiazole-4-carboxamido)-2-methyl-5-phenylpentanoate

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Technology Process of (2S,4R)-methyl 4-(2-((1R,3R)-1-methoxy-4-methyl-3-((2S,3S)-3-methyl-2-((R)-1-methylpiperidine-2-carboxamido)pentanamido)pentyl)thiazole-4-carboxamido)-2-methyl-5-phenylpentanoate

There total 14 articles about (2S,4R)-methyl 4-(2-((1R,3R)-1-methoxy-4-methyl-3-((2S,3S)-3-methyl-2-((R)-1-methylpiperidine-2-carboxamido)pentanamido)pentyl)thiazole-4-carboxamido)-2-methyl-5-phenylpentanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: (1R,3R)-2-(3-tert-butoxycarbonylamino-1-hydroxy-4-methylpentyl)thiazole-4-carboxylic acid ethyl ester

: 1427513-70-9
(2S,4R)-methyl 4-(2-((1R,3R)-1-methoxy-4-methyl-3-((2S,3S)-3-methyl-2-((R)-1-methylpiperidine-2-carboxamido)pentanamido)pentyl)thiazole-4-carboxamido)-2-methyl-5-phenylpentanoate

Guidance literature:: Multi-step reaction with 9 steps

1.1: potassium tert-butylate / tetrahydrofuran / 0.25 h / -78 °C / Inert atmosphere

1.2: 1 h / -78 °C / Inert atmosphere

2.1: dichloromethane / 1 h / 0 - 20 °C / Inert atmosphere

3.1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine / dichloromethane / 3 h / 0 - 20 °C

4.1: hydrogenchloride; sodium hydrogencarbonate / water

5.1: lithium hydroxide monohydrate / water; tetrahydrofuran / 5 h / 0 - 20 °C / Inert atmosphere

6.1: triethylamine; 1-hydroxy-7-aza-benzotriazole; HATU / dichloromethane / 3 h / 0 - 20 °C / Inert atmosphere

7.1: dichloromethane / 1 h / 0 - 20 °C / Inert atmosphere

8.1: triethylamine; 1-hydroxy-7-aza-benzotriazole; HATU / dichloromethane / 3 h / 0 - 20 °C / Inert atmosphere

9.1: hydrogenchloride; sodium hydrogencarbonate / water

With hydrogenchloride; 1-hydroxy-7-aza-benzotriazole; lithium hydroxide monohydrate; potassium tert-butylate; sodium hydrogencarbonate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; N-ethyl-N,N-diisopropylamine; HATU; In tetrahydrofuran; dichloromethane; water;
DOI:10.1039/c3ob27111k

Reference yield:

: C₂₄H₄₁N₃O₆S*C₂HF₃O₂

: 1427513-70-9
(2S,4R)-methyl 4-(2-((1R,3R)-1-methoxy-4-methyl-3-((2S,3S)-3-methyl-2-((R)-1-methylpiperidine-2-carboxamido)pentanamido)pentyl)thiazole-4-carboxamido)-2-methyl-5-phenylpentanoate

Guidance literature:: Multi-step reaction with 6 steps

1: hydrogenchloride; sodium hydrogencarbonate / water

2: lithium hydroxide monohydrate / water; tetrahydrofuran / 5 h / 0 - 20 °C / Inert atmosphere

3: triethylamine; 1-hydroxy-7-aza-benzotriazole; HATU / dichloromethane / 3 h / 0 - 20 °C / Inert atmosphere

4: dichloromethane / 1 h / 0 - 20 °C / Inert atmosphere

5: triethylamine; 1-hydroxy-7-aza-benzotriazole; HATU / dichloromethane / 3 h / 0 - 20 °C / Inert atmosphere

6: hydrogenchloride; sodium hydrogencarbonate / water

With hydrogenchloride; 1-hydroxy-7-aza-benzotriazole; lithium hydroxide monohydrate; sodium hydrogencarbonate; triethylamine; HATU; In tetrahydrofuran; dichloromethane; water;
DOI:10.1039/c3ob27111k