(2S,4R)-2-Amino-5,5,5-trifluoro-4-phenylsulfanylmethyl-pentanenitrile

Base Information

Chemical Name:(2S,4R)-2-Amino-5,5,5-trifluoro-4-phenylsulfanylmethyl-pentanenitrile
CAS No.:109685-51-0
Molecular Formula:C₁₂H₁₃F₃N₂S
Molecular Weight:274.31
Hs Code.:

Synonyms:

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (2S,4R)-2-Amino-5,5,5-trifluoro-4-phenylsulfanylmethyl-pentanenitrile

Chemical Property:

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Technology Process of (2S,4R)-2-Amino-5,5,5-trifluoro-4-phenylsulfanylmethyl-pentanenitrile

There total 9 articles about (2S,4R)-2-Amino-5,5,5-trifluoro-4-phenylsulfanylmethyl-pentanenitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 102854-63-7
4-trifluoromethyl-2-(5H)-furanone

: 109685-51-0
(2S,4R)-2-Amino-5,5,5-trifluoro-4-phenylsulfanylmethyl-pentanenitrile

Guidance literature:: Multi-step reaction with 9 steps

1: 88 percent / H₂ / 5percent Pd-C / methanol

2: toluene / 6 h / Heating

3: Et₃N / CH₂Cl₂ / 0 °C

4: NaH / tetrahydrofuran / Ambient temperature

5: c-HCl / acetic acid / 13 h / Heating

6: AcCl

7: DIBAL-H / diethyl ether / 0 °C

8: DMSO, ClCOCOCl, Et₃N / CH₂Cl₂

9: NH₄Cl, NH₄OH / ethanol

With hydrogenchloride; ammonium hydroxide; oxalyl dichloride; hydrogen; sodium hydride; diisobutylaluminium hydride; ammonium chloride; dimethyl sulfoxide; triethylamine; acetyl chloride; palladium on activated charcoal; In tetrahydrofuran; methanol; diethyl ether; ethanol; dichloromethane; acetic acid; toluene;
DOI:10.1016/S0040-4039(00)85148-5

Reference yield:

: 110847-11-5
3-trifluoromethyl-γ-butyrolactone

: 109685-51-0
(2S,4R)-2-Amino-5,5,5-trifluoro-4-phenylsulfanylmethyl-pentanenitrile

Guidance literature:: Multi-step reaction with 8 steps

1: toluene / 6 h / Heating

2: Et₃N / CH₂Cl₂ / 0 °C

3: NaH / tetrahydrofuran / Ambient temperature

4: c-HCl / acetic acid / 13 h / Heating

5: AcCl

6: DIBAL-H / diethyl ether / 0 °C

7: DMSO, ClCOCOCl, Et₃N / CH₂Cl₂

8: NH₄Cl, NH₄OH / ethanol

With hydrogenchloride; ammonium hydroxide; oxalyl dichloride; sodium hydride; diisobutylaluminium hydride; ammonium chloride; dimethyl sulfoxide; triethylamine; acetyl chloride; In tetrahydrofuran; diethyl ether; ethanol; dichloromethane; acetic acid; toluene;
DOI:10.1016/S0040-4039(00)85148-5

Reference yield:

: 109685-41-8
(R)-4,4,4-Trifluoro-3-phenylsulfanylmethyl-butan-1-ol

: 109685-51-0
(2S,4R)-2-Amino-5,5,5-trifluoro-4-phenylsulfanylmethyl-pentanenitrile

Guidance literature:: Multi-step reaction with 2 steps

1: DMSO, ClCOCOCl, Et₃N / CH₂Cl₂

2: NH₄Cl, NH₄OH / ethanol

With ammonium hydroxide; oxalyl dichloride; ammonium chloride; dimethyl sulfoxide; triethylamine; In ethanol; dichloromethane;
DOI:10.1016/S0040-4039(00)85148-5