2,4,6-Trimethyl-benzoic acid (2R,3R,4S,5R,6R)-2,4-bis-benzyloxy-6-benzyloxymethyl-5-((2S,3R,4S,5S,6R)-3,4-bis-benzyloxy-6-benzyloxymethyl-5-hydroxy-tetrahydro-pyran-2-yloxy)-tetrahydro-pyran-3-yl ester

Base Information

• Chemical Name: 2,4,6-Trimethyl-benzoic acid (2R,3R,4S,5R,6R)-2,4-bis-benzyloxy-6-benzyloxymethyl-5-((2S,3R,4S,5S,6R)-3,4-bis-benzyloxy-6-benzyloxymethyl-5-hydroxy-tetrahydro-pyran-2-yloxy)-tetrahydro-pyran-3-yl ester
• CAS No.: 120818-52-2
• Molecular Formula: C₆₄H₆₈O₁₂
• Molecular Weight: 1029.24

Synonyms:

Chemical Property of 2,4,6-Trimethyl-benzoic acid (2R,3R,4S,5R,6R)-2,4-bis-benzyloxy-6-benzyloxymethyl-5-((2S,3R,4S,5S,6R)-3,4-bis-benzyloxy-6-benzyloxymethyl-5-hydroxy-tetrahydro-pyran-2-yloxy)-tetrahydro-pyran-3-yl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2,4,6-Trimethyl-benzoic acid (2R,3R,4S,5R,6R)-2,4-bis-benzyloxy-6-benzyloxymethyl-5-((2S,3R,4S,5S,6R)-3,4-bis-benzyloxy-6-benzyloxymethyl-5-hydroxy-tetrahydro-pyran-2-yloxy)-tetrahydro-pyran-3-yl ester

There total 8 articles about 2,4,6-Trimethyl-benzoic acid (2R,3R,4S,5R,6R)-2,4-bis-benzyloxy-6-benzyloxymethyl-5-((2S,3R,4S,5S,6R)-3,4-bis-benzyloxy-6-benzyloxymethyl-5-hydroxy-tetrahydro-pyran-2-yloxy)-tetrahydro-pyran-3-yl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2,4,6-Trimethyl-benzoic acid (2R,3R,4S,5R,6R)-2,4-bis-benzyloxy-6-benzyloxymethyl-5-((2S,4aR,6S,7R,8S,8aS)-7,8-bis-benzyloxy-2-phenyl-hexahydro-pyrano[3,2-d][1,3]dioxin-6-yloxy)-tetrahydro-pyran-3-yl ester (120818-58-8) → 2,4,6-Trimethyl-benzoic acid (2R,3R,4S,5R,6R)-2,4-bis-benzyloxy-6-benzyloxymethyl-5-((2S,3R,4S,5S,6R)-3,4-bis-benzyloxy-6-benzyloxymethyl-5-hydroxy-tetrahydro-pyran-2-yloxy)-tetrahydro-pyran-3-yl ester (120818-52-2)

Guidance literature:

With aluminium trichloride; trimethylamine-borane; In tetrahydrofuran; Yield given;

DOI:10.1016/S0040-4039(00)80845-X

Reference yield:

benzyl bromide (100-39-0) → 2,4,6-Trimethyl-benzoic acid (2R,3R,4S,5R,6R)-2,4-bis-benzyloxy-6-benzyloxymethyl-5-((2S,3R,4S,5S,6R)-3,4-bis-benzyloxy-6-benzyloxymethyl-5-hydroxy-tetrahydro-pyran-2-yloxy)-tetrahydro-pyran-3-yl ester (120818-52-2)

Guidance literature:

Multi-step reaction with 5 steps

1: NaH / dimethylformamide

2: TMSOTf-MS₄A / 1,2-dichloro-ethane

3: NaOMe / methanol

4: DMAP / pyridine

5: BH₃*NMe₃-AlCl₃ / tetrahydrofuran

With dmap; aluminium trichloride; trimethylsilyl trifluoromethanesulfonate; trimethylamine-borane; sodium methylate; sodium hydride; In tetrahydrofuran; pyridine; methanol; 1,2-dichloro-ethane; N,N-dimethyl-formamide;

DOI:10.1016/S0040-4039(00)80845-X

Reference yield:

(2S,4aR,6S,7R,8R,8aR)-6-((2S,3aR,5R,6S,7S,7aR)-2-Benzyloxy-7-hydroxy-5-hydroxymethyl-2-methyl-tetrahydro-[1,3]dioxolo[4,5-b]pyran-6-yloxy)-2-phenyl-hexahydro-pyrano[3,2-d][1,3]dioxine-7,8-diol → 2,4,6-Trimethyl-benzoic acid (2R,3R,4S,5R,6R)-2,4-bis-benzyloxy-6-benzyloxymethyl-5-((2S,3R,4S,5S,6R)-3,4-bis-benzyloxy-6-benzyloxymethyl-5-hydroxy-tetrahydro-pyran-2-yloxy)-tetrahydro-pyran-3-yl ester (120818-52-2)

Guidance literature:

Multi-step reaction with 5 steps

1: NaH / dimethylformamide

2: TMSOTf-MS₄A / 1,2-dichloro-ethane

3: NaOMe / methanol

4: DMAP / pyridine

5: BH₃*NMe₃-AlCl₃ / tetrahydrofuran

With dmap; aluminium trichloride; trimethylsilyl trifluoromethanesulfonate; trimethylamine-borane; sodium methylate; sodium hydride; In tetrahydrofuran; pyridine; methanol; 1,2-dichloro-ethane; N,N-dimethyl-formamide;

DOI:10.1016/S0040-4039(00)80845-X

upstream raw materials:

2,4,6-Trimethyl-benzoic acid (2R,3R,4S,5R,6R)-2,4-bis-benzyloxy-6-benzyloxymethyl-5-((2S,4aR,6S,7R,8S,8aS)-7,8-bis-benzyloxy-2-phenyl-hexahydro-pyrano[3,2-d][1,3]dioxin-6-yloxy)-tetrahydro-pyran-3-yl ester

benzyl bromide

(2R,3R,4R,5R,6R)-2,4-Bis-benzyloxy-6-benzyloxymethyl-5-((2S,4aR,6S,7R,8S,8aS)-7,8-bis-benzyloxy-2-phenyl-hexahydro-pyrano[3,2-d][1,3]dioxin-6-yloxy)-tetrahydro-pyran-3-ol

Acetic acid (2R,3R,4S,5R,6R)-2,4-bis-benzyloxy-6-benzyloxymethyl-5-((2S,4aR,6S,7R,8S,8aS)-7,8-bis-benzyloxy-2-phenyl-hexahydro-pyrano[3,2-d][1,3]dioxin-6-yloxy)-tetrahydro-pyran-3-yl ester

Downstream raw materials:

C₉₃H₉₈O₁₈

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