6-[3-(tert-Butyl-dimethyl-silanyloxy)-propyl]-4-dodecyl-2-methoxy-1,4-dihydro-pyrimidine-5-carboxylic acid benzyl ester

Base Information

• Chemical Name: 6-[3-(tert-Butyl-dimethyl-silanyloxy)-propyl]-4-dodecyl-2-methoxy-1,4-dihydro-pyrimidine-5-carboxylic acid benzyl ester
• CAS No.: 150252-78-1
• Molecular Formula: C₃₄H₅₈N₂O₄Si
• Molecular Weight: 586.931
• Mol file: 150252-78-1.mol

Synonyms:

Chemical Property of 6-[3-(tert-Butyl-dimethyl-silanyloxy)-propyl]-4-dodecyl-2-methoxy-1,4-dihydro-pyrimidine-5-carboxylic acid benzyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 6-[3-(tert-Butyl-dimethyl-silanyloxy)-propyl]-4-dodecyl-2-methoxy-1,4-dihydro-pyrimidine-5-carboxylic acid benzyl ester

There total 2 articles about 6-[3-(tert-Butyl-dimethyl-silanyloxy)-propyl]-4-dodecyl-2-methoxy-1,4-dihydro-pyrimidine-5-carboxylic acid benzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

tert-butyldimethylsilyl chloride (18162-48-6) → 6-[3-(tert-Butyl-dimethyl-silanyloxy)-propyl]-4-dodecyl-2-methoxy-1,4-dihydro-pyrimidine-5-carboxylic acid benzyl ester (150252-78-1)

Guidance literature:

Multi-step reaction with 2 steps

2: 1.) Knoevenagel condensation, 2.) DMF, 60 deg C

DOI:10.1021/jo00067a014

Reference yield:

tridecanal (10486-19-8) + O-methylisourea hemisulfate (29427-58-5,24285-39-0) + 6-(tert-Butyl-dimethyl-silanyloxy)-3-oxo-hexanoic acid benzyl ester (150252-75-8) → 6-[3-(tert-Butyl-dimethyl-silanyloxy)-propyl]-4-dodecyl-2-methoxy-1,4-dihydro-pyrimidine-5-carboxylic acid benzyl ester (150252-78-1)

Guidance literature:

Yield given. Multistep reaction; 1.) Knoevenagel condensation, 2.) DMF, 60 deg C;

DOI:10.1021/jo00067a014

Reference yield:

6-[3-(tert-Butyl-dimethyl-silanyloxy)-propyl]-4-dodecyl-2-methoxy-1,4-dihydro-pyrimidine-5-carboxylic acid benzyl ester (150252-78-1) → (5S,9S,10R)-9-Dodecyl-7-imino-1-oxa-6,8-diaza-spiro[4.5]decane-10-carboxylic acid benzyl ester; hydrochloride

Guidance literature:

Multi-step reaction with 2 steps

1: 1.) deprotection, 2.) ammonolysis, MeOH

2: 91 percent / Et₃N / CHCl₃ / Heating

triethylamine; In chloroform;

DOI:10.1021/jo00067a014

upstream raw materials:

tridecanal

O-methylisourea hemisulfate

6-(tert-Butyl-dimethyl-silanyloxy)-3-oxo-hexanoic acid benzyl ester

tert-butyldimethylsilyl chloride

Downstream raw materials:

4-Dodecyl-6-(3-hydroxy-propyl)-2-methoxy-1,4-dihydro-pyrimidine-5-carboxylic acid benzyl ester