Acetic acid (1R,2R,3R,4R)-3-acetoxy-1-[(R)-1-{(4R,5R,6R)-6-[(R)-2-(tert-butyl-diphenyl-silanyloxy)-1-methyl-ethyl]-2,2,5-trimethyl-[1,3]dioxan-4-yl}-2-oxo-2-(2-oxo-oxazolidin-3-yl)-ethyl]-2,4-dimethyl-5-oxo-pentyl ester

Base Information

Chemical Name:Acetic acid (1R,2R,3R,4R)-3-acetoxy-1-[(R)-1-{(4R,5R,6R)-6-[(R)-2-(tert-butyl-diphenyl-silanyloxy)-1-methyl-ethyl]-2,2,5-trimethyl-[1,3]dioxan-4-yl}-2-oxo-2-(2-oxo-oxazolidin-3-yl)-ethyl]-2,4-dimethyl-5-oxo-pentyl ester
CAS No.:121440-51-5
Molecular Formula:C₄₂H₅₉NO₁₁Si
Molecular Weight:782.016
Hs Code.:

Acetic acid (1R,2R,3R,4R)-3-acetoxy-1-[(R)-1-{(4R,5R,6R)-6-[(R)-2-(tert-butyl-diphenyl-silanyloxy)-1-methyl-ethyl]-2,2,5-trimethyl-[1,3]dioxan-4-yl}-2-oxo-2-(2-oxo-oxazolidin-3-yl)-ethyl]-2,4-dimethyl-5-oxo-pentyl ester

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Suppliers and Price of Acetic acid (1R,2R,3R,4R)-3-acetoxy-1-[(R)-1-{(4R,5R,6R)-6-[(R)-2-(tert-butyl-diphenyl-silanyloxy)-1-methyl-ethyl]-2,2,5-trimethyl-[1,3]dioxan-4-yl}-2-oxo-2-(2-oxo-oxazolidin-3-yl)-ethyl]-2,4-dimethyl-5-oxo-pentyl ester

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Chemical Property of Acetic acid (1R,2R,3R,4R)-3-acetoxy-1-[(R)-1-{(4R,5R,6R)-6-[(R)-2-(tert-butyl-diphenyl-silanyloxy)-1-methyl-ethyl]-2,2,5-trimethyl-[1,3]dioxan-4-yl}-2-oxo-2-(2-oxo-oxazolidin-3-yl)-ethyl]-2,4-dimethyl-5-oxo-pentyl ester

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Technology Process of Acetic acid (1R,2R,3R,4R)-3-acetoxy-1-[(R)-1-{(4R,5R,6R)-6-[(R)-2-(tert-butyl-diphenyl-silanyloxy)-1-methyl-ethyl]-2,2,5-trimethyl-[1,3]dioxan-4-yl}-2-oxo-2-(2-oxo-oxazolidin-3-yl)-ethyl]-2,4-dimethyl-5-oxo-pentyl ester

There total 11 articles about Acetic acid (1R,2R,3R,4R)-3-acetoxy-1-[(R)-1-{(4R,5R,6R)-6-[(R)-2-(tert-butyl-diphenyl-silanyloxy)-1-methyl-ethyl]-2,2,5-trimethyl-[1,3]dioxan-4-yl}-2-oxo-2-(2-oxo-oxazolidin-3-yl)-ethyl]-2,4-dimethyl-5-oxo-pentyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 106568-13-2,121440-66-2
(2R,3R,4R)-5-((tert-butyldiphenylsilyl)oxy)-2,4-dimethyl-3-((triethylsilyl)oxy)pentanal

: 121440-51-5
Acetic acid (1R,2R,3R,4R)-3-acetoxy-1-[(R)-1-{(4R,5R,6R)-6-[(R)-2-(tert-butyl-diphenyl-silanyloxy)-1-methyl-ethyl]-2,2,5-trimethyl-[1,3]dioxan-4-yl}-2-oxo-2-(2-oxo-oxazolidin-3-yl)-ethyl]-2,4-dimethyl-5-oxo-pentyl ester

Guidance literature:: Multi-step reaction with 10 steps

1: 1.) Bu₂BOTf, Et₃N, 2.) H₂O₂ / 1.) CH₂Cl₂, from -78 deg C to -50 deg C, 2.) pH 7

2: pTsOH, H₂O / tetrahydrofuran

3: pTsOH

4: 1.) O₃, 2.) Me₂S / 1.) MeOH, -78 deg C

5: CrCl₂ / tetrahydrofuran / -25 °C

6: pyridine

7: 1.) O₃, 2.) Me₂S / methanol / -20 °C

9: pyridine

10: 1.) O₃, 2.) Me₂S / 1.) MeOH, -78 deg C

With pyridine; chromium dichloride; dimethylsulfide; di-n-butylboryl trifluoromethanesulfonate; water; dihydrogen peroxide; toluene-4-sulfonic acid; ozone; triethylamine; In tetrahydrofuran; methanol;
DOI:10.1021/jo00274a008

Reference yield:

: 3-[(2S,3R,4R,5R,6R)-7-(tert-Butyl-diphenyl-silanyloxy)-3,5-dihydroxy-4,6-dimethyl-2-vinyl-heptanoyl]-oxazolidin-2-one

: 121440-51-5
Acetic acid (1R,2R,3R,4R)-3-acetoxy-1-[(R)-1-{(4R,5R,6R)-6-[(R)-2-(tert-butyl-diphenyl-silanyloxy)-1-methyl-ethyl]-2,2,5-trimethyl-[1,3]dioxan-4-yl}-2-oxo-2-(2-oxo-oxazolidin-3-yl)-ethyl]-2,4-dimethyl-5-oxo-pentyl ester

Guidance literature:: Multi-step reaction with 8 steps

1: pTsOH

2: 1.) O₃, 2.) Me₂S / 1.) MeOH, -78 deg C

3: CrCl₂ / tetrahydrofuran / -25 °C

4: pyridine

5: 1.) O₃, 2.) Me₂S / methanol / -20 °C

7: pyridine

8: 1.) O₃, 2.) Me₂S / 1.) MeOH, -78 deg C

With pyridine; chromium dichloride; dimethylsulfide; toluene-4-sulfonic acid; ozone; In tetrahydrofuran; methanol;
DOI:10.1021/jo00274a008

Reference yield:

: 121471-29-2
3-((S)-2-{(4R,5R,6R)-6-[(R)-2-(tert-Butyl-diphenyl-silanyloxy)-1-methyl-ethyl]-2,2,5-trimethyl-[1,3]dioxan-4-yl}-but-3-enoyl)-oxazolidin-2-one

: 121440-51-5
Acetic acid (1R,2R,3R,4R)-3-acetoxy-1-[(R)-1-{(4R,5R,6R)-6-[(R)-2-(tert-butyl-diphenyl-silanyloxy)-1-methyl-ethyl]-2,2,5-trimethyl-[1,3]dioxan-4-yl}-2-oxo-2-(2-oxo-oxazolidin-3-yl)-ethyl]-2,4-dimethyl-5-oxo-pentyl ester

Guidance literature:: Multi-step reaction with 7 steps

1: 1.) O₃, 2.) Me₂S / 1.) MeOH, -78 deg C

2: CrCl₂ / tetrahydrofuran / -25 °C

3: pyridine

4: 1.) O₃, 2.) Me₂S / methanol / -20 °C

6: pyridine

7: 1.) O₃, 2.) Me₂S / 1.) MeOH, -78 deg C

With pyridine; chromium dichloride; dimethylsulfide; ozone; In tetrahydrofuran; methanol;
DOI:10.1021/jo00274a008