((2S,4R)-2-{3-[Bis-(4-fluoro-phenyl)-methyl]-1-methyl-naphthalen-2-yloxymethyl}-6-methoxy-tetrahydro-pyran-4-yloxy)-tert-butyl-diphenyl-silane

Base Information

Chemical Name:((2S,4R)-2-{3-[Bis-(4-fluoro-phenyl)-methyl]-1-methyl-naphthalen-2-yloxymethyl}-6-methoxy-tetrahydro-pyran-4-yloxy)-tert-butyl-diphenyl-silane
CAS No.:136007-23-3
Molecular Formula:C₄₇H₄₈F₂O₄Si
Molecular Weight:742.978
Hs Code.:

((2S,4R)-2-{3-[Bis-(4-fluoro-phenyl)-methyl]-1-methyl-naphthalen-2-yloxymethyl}-6-methoxy-tetrahydro-pyran-4-yloxy)-tert-butyl-diphenyl-silane

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Chemical Property of ((2S,4R)-2-{3-[Bis-(4-fluoro-phenyl)-methyl]-1-methyl-naphthalen-2-yloxymethyl}-6-methoxy-tetrahydro-pyran-4-yloxy)-tert-butyl-diphenyl-silane

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Technology Process of ((2S,4R)-2-{3-[Bis-(4-fluoro-phenyl)-methyl]-1-methyl-naphthalen-2-yloxymethyl}-6-methoxy-tetrahydro-pyran-4-yloxy)-tert-butyl-diphenyl-silane

There total 8 articles about ((2S,4R)-2-{3-[Bis-(4-fluoro-phenyl)-methyl]-1-methyl-naphthalen-2-yloxymethyl}-6-methoxy-tetrahydro-pyran-4-yloxy)-tert-butyl-diphenyl-silane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 883-99-8
3-hydroxy-2-naphthoic acid methyl ester

: 136007-23-3,136008-09-8
((2S,4R)-2-{3-[Bis-(4-fluoro-phenyl)-methyl]-1-methyl-naphthalen-2-yloxymethyl}-6-methoxy-tetrahydro-pyran-4-yloxy)-tert-butyl-diphenyl-silane

Guidance literature:: Multi-step reaction with 5 steps

1: 70 percent / tetrahydrofuran / 0.5 h / 25 °C

2: 82 percent / conc. HCl, H₂ / 10percent Pd/C / acetic acid / 25 °C / 750.06 Torr

3: 34 percent / aq. NaOH / ethanol / 1 h / 80 °C

4: 52 percent / sodium bis(2-methoxyethoxy)dihydroaluminate / toluene; xylene / 2 h / Heating

5: K₂CO₃, hydroquinone / dimethylsulfoxide / 1 h / 40 °C

With hydrogenchloride; sodium hydroxide; hydrogen; potassium carbonate; hydroquinone; sodium bis(2-methoxyethoxy)aluminium dihydride; palladium on activated charcoal; In tetrahydrofuran; ethanol; acetic acid; dimethyl sulfoxide; toluene; xylene;
DOI:10.1021/jm00114a004

Reference yield:

: 82378-95-8
γ--β-naphthol

: 136007-23-3,136008-09-8
((2S,4R)-2-{3-[Bis-(4-fluoro-phenyl)-methyl]-1-methyl-naphthalen-2-yloxymethyl}-6-methoxy-tetrahydro-pyran-4-yloxy)-tert-butyl-diphenyl-silane

Guidance literature:: Multi-step reaction with 4 steps

1: 82 percent / conc. HCl, H₂ / 10percent Pd/C / acetic acid / 25 °C / 750.06 Torr

2: 34 percent / aq. NaOH / ethanol / 1 h / 80 °C

3: 52 percent / sodium bis(2-methoxyethoxy)dihydroaluminate / toluene; xylene / 2 h / Heating

4: K₂CO₃, hydroquinone / dimethylsulfoxide / 1 h / 40 °C

With hydrogenchloride; sodium hydroxide; hydrogen; potassium carbonate; hydroquinone; sodium bis(2-methoxyethoxy)aluminium dihydride; palladium on activated charcoal; In ethanol; acetic acid; dimethyl sulfoxide; toluene; xylene;
DOI:10.1021/jm00114a004

Reference yield:

: 352-13-6
4-flourophenylmagnesium bromide

: 136007-23-3,136008-09-8
((2S,4R)-2-{3-[Bis-(4-fluoro-phenyl)-methyl]-1-methyl-naphthalen-2-yloxymethyl}-6-methoxy-tetrahydro-pyran-4-yloxy)-tert-butyl-diphenyl-silane

Guidance literature:: Multi-step reaction with 5 steps

1: 70 percent / tetrahydrofuran / 0.5 h / 25 °C

2: 82 percent / conc. HCl, H₂ / 10percent Pd/C / acetic acid / 25 °C / 750.06 Torr

3: 34 percent / aq. NaOH / ethanol / 1 h / 80 °C

4: 52 percent / sodium bis(2-methoxyethoxy)dihydroaluminate / toluene; xylene / 2 h / Heating

5: K₂CO₃, hydroquinone / dimethylsulfoxide / 1 h / 40 °C

With hydrogenchloride; sodium hydroxide; hydrogen; potassium carbonate; hydroquinone; sodium bis(2-methoxyethoxy)aluminium dihydride; palladium on activated charcoal; In tetrahydrofuran; ethanol; acetic acid; dimethyl sulfoxide; toluene; xylene;
DOI:10.1021/jm00114a004