{(E)-(R)-1-[(2S,5S)-5-((E)-(R)-1-Benzyloxycarbonylamino-5,5-dimethoxy-pent-2-enyl)-3,6-dioxo-piperazin-2-yl]-5,5-dimethoxy-pent-2-enyl}-carbamic acid benzyl ester

Base Information

• Chemical Name: {(E)-(R)-1-[(2S,5S)-5-((E)-(R)-1-Benzyloxycarbonylamino-5,5-dimethoxy-pent-2-enyl)-3,6-dioxo-piperazin-2-yl]-5,5-dimethoxy-pent-2-enyl}-carbamic acid benzyl ester
• CAS No.: 74015-64-8
• Molecular Formula: C₃₄H₄₄N₄O₁₀
• Molecular Weight: 668.744
• Mol file: 74015-64-8.mol

Synonyms:

Chemical Property of {(E)-(R)-1-[(2S,5S)-5-((E)-(R)-1-Benzyloxycarbonylamino-5,5-dimethoxy-pent-2-enyl)-3,6-dioxo-piperazin-2-yl]-5,5-dimethoxy-pent-2-enyl}-carbamic acid benzyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of {(E)-(R)-1-[(2S,5S)-5-((E)-(R)-1-Benzyloxycarbonylamino-5,5-dimethoxy-pent-2-enyl)-3,6-dioxo-piperazin-2-yl]-5,5-dimethoxy-pent-2-enyl}-carbamic acid benzyl ester

There total 1 articles about {(E)-(R)-1-[(2S,5S)-5-((E)-(R)-1-Benzyloxycarbonylamino-5,5-dimethoxy-pent-2-enyl)-3,6-dioxo-piperazin-2-yl]-5,5-dimethoxy-pent-2-enyl}-carbamic acid benzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(2R,3S)-3-Amino-2-((E)-4,4-dimethoxy-but-1-enyl)-4-oxo-azetidine-1-carboxylic acid benzyl ester → {(E)-(R)-1-[(2S,5R)-5-((E)-(S)-1-Benzyloxycarbonylamino-5,5-dimethoxy-pent-2-enyl)-3,6-dioxo-piperazin-2-yl]-5,5-dimethoxy-pent-2-enyl}-carbamic acid benzyl ester + {(E)-(R)-1-[(2S,5S)-5-((E)-(R)-1-Benzyloxycarbonylamino-5,5-dimethoxy-pent-2-enyl)-3,6-dioxo-piperazin-2-yl]-5,5-dimethoxy-pent-2-enyl}-carbamic acid benzyl ester (74015-63-7,74015-64-8)

Guidance literature:

Yield given. Yields of byproduct given; Ambient temperature;

DOI:10.1021/ja00526a076

Reference yield:

{(E)-(R)-1-[(2S,5S)-5-((E)-(R)-1-Benzyloxycarbonylamino-5,5-dimethoxy-pent-2-enyl)-3,6-dioxo-piperazin-2-yl]-5,5-dimethoxy-pent-2-enyl}-carbamic acid benzyl ester (74015-63-7,74015-64-8) → C30H32N4O6 (74015-66-0)

Guidance literature:

Multi-step reaction with 2 steps

1: 98 percent / hydrogen / PtO₂ / methanol / Ambient temperature

2: 91 percent / camphorsulfonic acid, quinoline / toluene; 1,2-dichloro-ethane / Heating

With quinoline; camphor-10-sulfonic acid; hydrogen; platinum(IV) oxide; In methanol; 1,2-dichloro-ethane; toluene;

DOI:10.1021/ja00526a076

Reference yield:

{(E)-(R)-1-[(2S,5S)-5-((E)-(R)-1-Benzyloxycarbonylamino-5,5-dimethoxy-pent-2-enyl)-3,6-dioxo-piperazin-2-yl]-5,5-dimethoxy-pent-2-enyl}-carbamic acid benzyl ester (74015-63-7,74015-64-8) → C34H42Cl2N4O8 (74015-67-1)

Guidance literature:

Multi-step reaction with 3 steps

1: 98 percent / hydrogen / PtO₂ / methanol / Ambient temperature

2: 91 percent / camphorsulfonic acid, quinoline / toluene; 1,2-dichloro-ethane / Heating

3: Cl₂ / CH₂Cl₂ / 0 °C

With quinoline; camphor-10-sulfonic acid; hydrogen; chlorine; platinum(IV) oxide; In methanol; dichloromethane; 1,2-dichloro-ethane; toluene;

DOI:10.1021/ja00526a076

Downstream raw materials:

C₃₀H₃₂N₄O₆

C₃₄H₄₂Cl₂N₄O₈

dl-593A