(4aS,7aS,10aS)-2-Benzyl-1-oxo-2,3,4,4a,7,7a,9,10-octahydro-1H-pyrrolo[2,3-i]isoquinoline-8-carboxylic acid ethyl ester

Base Information

• Chemical Name: (4aS,7aS,10aS)-2-Benzyl-1-oxo-2,3,4,4a,7,7a,9,10-octahydro-1H-pyrrolo[2,3-i]isoquinoline-8-carboxylic acid ethyl ester
• CAS No.: 138713-70-9
• Molecular Formula: C₂₁H₂₆N₂O₃
• Molecular Weight: 354.449
• Mol file: 138713-70-9.mol

Synonyms:

Chemical Property of (4aS,7aS,10aS)-2-Benzyl-1-oxo-2,3,4,4a,7,7a,9,10-octahydro-1H-pyrrolo[2,3-i]isoquinoline-8-carboxylic acid ethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (4aS,7aS,10aS)-2-Benzyl-1-oxo-2,3,4,4a,7,7a,9,10-octahydro-1H-pyrrolo[2,3-i]isoquinoline-8-carboxylic acid ethyl ester

There total 18 articles about (4aS,7aS,10aS)-2-Benzyl-1-oxo-2,3,4,4a,7,7a,9,10-octahydro-1H-pyrrolo[2,3-i]isoquinoline-8-carboxylic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-[N-benzyl-N-hexa-3'(Z),5'-dien-1'-yl]carbamoyl-2,3-dihydropyrrole-1-carboxylic acid ethyl ester (138713-74-3) → (4aR,7aS,10aS)-2-Benzyl-1-oxo-2,3,4,4a,7,7a,9,10-octahydro-1H-pyrrolo[2,3-i]isoquinoline-8-carboxylic acid ethyl ester (138713-70-9,139757-08-7) + (4aS,7aS,10aS)-2-Benzyl-1-oxo-2,3,4,4a,7,7a,9,10-octahydro-1H-pyrrolo[2,3-i]isoquinoline-8-carboxylic acid ethyl ester (138713-70-9,139757-08-7)

Guidance literature:

With ethylaluminum dichloride; In toluene; at 120 ℃; for 100h; Yield given. Yields of byproduct given; Heating;

DOI:10.1016/0040-4039(91)80198-F

Reference yield:

4-[N-benzyl-N-hexa-3'(Z),5'-dien-1'-yl]carbamoyl-2,3-dihydropyrrole-1-carboxylic acid ethyl ester (138713-74-3) → (4aR,7aS,10aS)-2-Benzyl-1-oxo-2,3,4,4a,7,7a,9,10-octahydro-1H-pyrrolo[2,3-i]isoquinoline-8-carboxylic acid ethyl ester (138713-70-9,139757-08-7) + (4aS,7aS,10aS)-2-Benzyl-1-oxo-2,3,4,4a,7,7a,9,10-octahydro-1H-pyrrolo[2,3-i]isoquinoline-8-carboxylic acid ethyl ester (138713-70-9,139757-08-7)

Guidance literature:

With ethylaluminum dichloride; In toluene; at 120 ℃; for 100h; Yield given. Yields of byproduct given; Heating;

DOI:10.1016/0040-4039(91)80198-F

Reference yield:

ethyl 2-oxopyrrolidine-1-carboxylate (4036-03-7) → (4aR,7aS,10aS)-2-Benzyl-1-oxo-2,3,4,4a,7,7a,9,10-octahydro-1H-pyrrolo[2,3-i]isoquinoline-8-carboxylic acid ethyl ester (138713-70-9,139757-08-7)

Guidance literature:

Multi-step reaction with 4 steps

2: ClCO-COCl / CH₂Cl₂ / 25 °C

3: 77 percent

4: EtAlCl₂ / toluene / 100 h / 120 °C / Heating

With oxalyl dichloride; ethylaluminum dichloride; In dichloromethane; toluene;

DOI:10.1016/0040-4039(91)80198-F

upstream raw materials:

4-[N-benzyl-N-hexa-3'(Z),5'-dien-1'-yl]carbamoyl-2,3-dihydropyrrole-1-carboxylic acid ethyl ester

4-(benzylhexa-3(E),5-dienylcarbamoyl)-2,3-dihydropyrrole-1-carboxylic acid ethyl ester

ethyl 2-oxopyrrolidine-1-carboxylate

4,5-dihydropyrrole-1,3-dicarboxylic acid 1ethyl ester

Downstream raw materials:

(4aS,7aS,10aR)-2-Benzyl-8,8-dimethyl-1,2,3,4,4a,7,7a,8,9,10-decahydro-pyrrolo[2,3-i]isoquinolin-8-ium; iodide

(4aR,7aS,10aR)-2-Benzyl-8,8-dimethyl-1,2,3,4,4a,7,7a,8,9,10-decahydro-pyrrolo[2,3-i]isoquinolin-8-ium; iodide