4036-03-7

Upstream product

• 616-45-5 2-pyrrolidinon 
• 51-79-6 urethane 
• 4635-59-0 4-Chlorobutanoyl chloride 
• 541-41-3 chloroformic acid ethyl ester 
• 515-84-4 Ethyl trichloroacetate 
• 5470-26-8 ethyl pyrrolidine-1-carboxylate 

Downstream Products

• 246181-63-5 1-ethoxycarbonyl-5-fluoro-2-pyrrolidinone 
• 159972-38-0 2-oxopyrrolidine-1,3-dicarboxylic acid 3-benzyl ester 1-ethyl ester 
• 54621-11-3 1,4-dioxa-spiro[4.5]decan-8-one phenylhydrazone 
• 138713-70-9 (4aS,7aS,10aS)-2-Benzyl-1-oxo-2,3,4,4a,7,7a,9,10-octahydro-1H-pyrrolo[2,3-i]isoquinoline-8-carboxylic acid ethyl ester 
• 138713-70-9 (4aR,7aS,10aS)-2-Benzyl-1-oxo-2,3,4,4a,7,7a,9,10-octahydro-1H-pyrrolo[2,3-i]isoquinoline-8-carboxylic acid ethyl ester 
• 159972-42-6 3-{Benzyl-[2-(3-dimethylcarbamoyl-1,1-dioxo-2,5-dihydro-1H-1λ⁶-thiophen-2-yl)-ethyl]-carbamoyl}-2-oxo-pyrrolidine-1-carboxylic acid ethyl ester 
• 159972-45-9 4-{Benzyl-[2-(3-dimethylcarbamoyl-1,1-dioxo-2,5-dihydro-1H-1λ⁶-thiophen-2-yl)-ethyl]-carbamoyl}-2,3-dihydro-pyrrole-1-carboxylic acid ethyl ester 
• 449143-50-4 4-[N-benzyl-N-4'-benzyloxymethylhexa-3'(Z),5'-dien-1'-yl]carbamoyl-2,3-dihydropyrrole-1-carboxylic acid ethyl ester 
• 449143-44-6 4-[benzyl-(4-benzyloxymethylhexa-3(Z),5-dienyl)carbamoyl]-2,3-dihydropyrrole-1-carboxylic acid ethyl ester 
• 449143-38-8 4-[N-benzyl-N-4'-methoxycarbonylhexa-3'(Z),5'-dien-1'-yl]carbamoyl-2,3-dihydropyrrole-1-carboxylic acid ethyl ester 
• 138713-69-6 4-(benzylhexa-3(E),5-dienylcarbamoyl)-2,3-dihydropyrrole-1-carboxylic acid ethyl ester 
• 138713-74-3 4-[N-benzyl-N-hexa-3'(Z),5'-dien-1'-yl]carbamoyl-2,3-dihydropyrrole-1-carboxylic acid ethyl ester 
• 449143-39-9 1-ethyl 8-methyl (3aS,7aR,10aS)-5-benzyl-4-oxo-2,3,5,6,7,7a,10,10a-octahydropyrrolo[2.3-i]isoquinoline-1,8(4H)-dicarboxylate 
• 106412-38-8 2-ethoxy-N-etoxycarbonylpyrrolidine 

Relevant academic research and scientific papers

INDIRECT ELECTROOXIDATION OF N-PROTECTED AMINES TO AMIDES WITH A DOUBLE MEDIATORY SYSTEM CONSISTING OF RuO4 AND Cl

Indirect electrooxidative conversion of N-protected aliphatic amines into the corresponding amides with RuO4 in a saturated NaCl-acetone system proceeds in excellent yields.

Method for synthesizing nefiracetam intermediate 2-pyrrolidone

The invention discloses a method for synthesizing nevacetam intermediate 2-pyrrolidone, which includes reacting 4-halogenated butyryl chloride with carbamate under the action of a catalyst to obtain 2-pyrrolidone; 1) mixing 4-halogenated butyryl chloride, catalyst and solvent A under protective gas, raising the temperature to 100-125 DEG C, raising the pressure to 3-5 atmospheric pressure, and dropping the solution of carbamate and solvent B for 40-60min, after the end of the reaction, continuing to react for 5-7h under the maintenance condition, raising the temperature to 135-160 DEG C, raising the pressure to 5-7 atmospheric pressure, reacting for 6-8h, then cooling to 40-60 DEG C and dropping to normal pressure, dripping alkali water for 20-30min, raising the temperature to 120-140 DEGC, reacting for 3-6h, raising the temperature to 140-160 DEG C, raising the pressure to 7-10 atmospheric pressure and reacting for 4-6h to the end, 2) pouring the product into 3-4 times volume of water after cooling, extracting and stratifying by adding solvent C, concentrating and evaporating the solvent to obtain the product after washing and drying of the organic layer. The method for synthesizing nevacetam intermediate 2-pyrrolidone has the advantages of low cost and high yield.

Hydrozirconation of four-, five-, six- and seven-membered N-alkoxycarbonyl lactams to lactamols

A general, practical, and efficient reduction of four-, five-, six- and, seven-membered N-alkoxycarbonyl lactams to the aldehyde oxidation state is reported. The reduction methodology involves the hydrozirconation reaction by Cp2Zr(H)Cl under m

Preparation of N-alkoxycarbonyl-substituted cyclic lactams and ketones

N-alkoxycarbonyl-substituted cyclic lactams and nitrogen-containing cyclic ketones are prepared by reaction of a C1-20 alkyl ester of trichloroacetic acid with the corresponding cyclic lactam or nitrogen-containing cyclic ketone.