2'-hydroxy-3,4,4',6'-tetramethoxychalcone

Base Information

• Chemical Name: 2'-hydroxy-3,4,4',6'-tetramethoxychalcone
• CAS No.: 114021-60-2
• Molecular Formula: C₁₉H₂₀O₆
• Molecular Weight: 344.364
• Mol file: 114021-60-2.mol

Synonyms:

Chemical Property of 2'-hydroxy-3,4,4',6'-tetramethoxychalcone

Chemical Property:

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2'-hydroxy-3,4,4',6'-tetramethoxychalcone

There total 18 articles about 2'-hydroxy-3,4,4',6'-tetramethoxychalcone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.1%

2-hydroxy-4,6-dimethoxyacetophenone (90-24-4) + 3,4-dimethoxy-benzaldehyde (120-14-9) → 3-(3,4-dimethoxyphenyl)-1-(2-hydroxy-4,6-dimethoxyphenyl)prop-2-en-1-one (10496-67-0,114021-60-2)

Guidance literature:

With potassium hydroxide; In N,N-dimethyl-formamide; at 20 ℃; for 4h;

DOI:10.14233/ajchem.2016.19613

Reference yield: 90.0%

1-(2,4,6-trimethoxyphenyl)-3-(3,4-dimethoxyphenyl)propenone (76650-20-9) → 2'-hydroxy-3,4,4',6'-tetramethoxychalcone (114021-60-2)

Guidance literature:

With boron tribromide; In dichloromethane; at 0 ℃; for 0.5h;

DOI:10.1016/j.tet.2004.01.023

Reference yield: 84.0%

2-hydroxy-4,6-dimethoxyacetophenone (90-24-4) + 3,4-dimethoxy-benzaldehyde (120-14-9) → 2'-hydroxy-3,4,4',6'-tetramethoxychalcone (114021-60-2)

Guidance literature:

With potassium hydroxide; In ethanol; water; at 0 - 20 ℃;

DOI:10.1055/s-0036-1591773

upstream raw materials:

2-hydroxy-4,6-dimethoxyacetophenone

3,4-dimethoxy-benzaldehyde

2,4,6-trihydroxyacetophenone

dimethyl sulfate

Downstream raw materials:

2,3-dihydro-5,7-dimethoxy-2-(4'-dimethoxyphenyl)-4H-1-benzopyran-4-one

Bis(3,4,4',6'-tetramethoxy-2'-chalconoxy)methane

2,5-Dihydro-6,8-dimethoxy-3-(3',4'-dimethoxyphenyl)-1-benzoxepin

(Z)-2-(3,4-dimethoxybenzylidene)-4,6-dimethoxybenzofuran-3(2H)-one

Refernces

• 1、 Choe, Jung-Won,Heo, Hee-Young,Jung, Se-Hui,Kim, Jaehyun,Lee, Kooyeon. "Anti‐melanogenic properties of velutin and its analogs?". . . Retrieved 2021/06/03.
• 2、 -. "Hydroxyaurone derivative as well as preparation method and application thereof". . . Retrieved 2021/07/14.