Ethanone, 1-(trimethylpyrazinyl)- (9CI)

Base Information

• Chemical Name: Ethanone, 1-(trimethylpyrazinyl)- (9CI)
• CAS No.: 125186-38-1
• Molecular Formula: C9H12N2O
• Molecular Weight: 164.20400
• Mol file: 125186-38-1.mol

Synonyms:1-(3,5,6-Trimethyl-pyrazin-2-yl)-ethanone;1-trimethylpyrazinyl-ethanone;1-Trimethylpyrazinyl-aethanon;

Chemical Property of Ethanone, 1-(trimethylpyrazinyl)- (9CI)

Chemical Property:

• Melting Point: 61-62 °C
• Boiling Point: 113-114 °C(Press: 14 Torr)
• PKA: 1.51±0.10(Predicted)
• PSA: 42.85000
• Density: 1.050±0.06 g/cm3(Predicted)
• LogP: 1.60440

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Ethanone, 1-(trimethylpyrazinyl)- (9CI)

There total 4 articles about Ethanone, 1-(trimethylpyrazinyl)- (9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 7.6%

2,5-dimethyl-pyrazine (123-32-0) + acetaldehyde (75-07-0,9002-91-9) → 2-acetyl-3,5,6-trimethylpyrazine (125186-38-1) + 2,5-diacetyl-3,6-dimethylpyrazine (62025-68-7)

Guidance literature:

With tert.-butylhydroperoxide; di-tert-butyl peroxide; sulfuric acid; iron(II) sulfate; In water; at 5 - 15 ℃; for 1h;

DOI:10.1135/cccc19951551

Reference yield:

3,5,6-trimethyl-1,2-dihydropyrazin-2-one (57355-08-5) → 2-acetyl-3,5,6-trimethylpyrazine (125186-38-1)

Guidance literature:

Multi-step reaction with 3 steps

1: PBr₃

3: diethyl ether / anschliessend Behandeln mit wss. HCl

With diethyl ether; phosphorus tribromide;

DOI:10.1021/ja01591a029

Reference yield:

bromo-trimethyl-pyrazine (820250-41-7) → 2-acetyl-3,5,6-trimethylpyrazine (125186-38-1)

Guidance literature:

Multi-step reaction with 2 steps

2: diethyl ether / anschliessend Behandeln mit wss. HCl

With diethyl ether;

DOI:10.1021/ja01591a029

upstream raw materials:

3,5,6-trimethyl-pyrazine-2-carbonitrile

methylmagnesium bromide

2,5-dimethyl-pyrazine

acetaldehyde

Refernces