57355-08-5

Usage

Uses

Used in Food Industry:
3,5,6-triMethylpyrazin-2-ol is used as a flavoring agent for its nutty and roasted taste, enhancing the flavor profiles of various food products.
Used in Fragrance and Perfume Industry:
3,5,6-triMethylpyrazin-2-ol is utilized in the production of fragrances and perfumes, where its distinctive odor adds depth and complexity to scent compositions.
Used in Pharmaceutical Research:
3,5,6-triMethylpyrazin-2-ol is studied for its potential medicinal properties, such as anti-inflammatory and antioxidant effects, indicating its possible use in the development of new therapeutic agents.
Used in Chemical Research:
Due to its unique chemical structure and properties, 3,5,6-triMethylpyrazin-2-ol is a valuable ingredient for research in various chemical industries, paving the way for innovative applications and products.

Upstream product

• 876499-32-0 2-bromo-propionic acid-(1-methyl-2-oxo-propylamide) 
• 57-48-7 D-Fructose 
• 3130-87-8 ASPARAGINE 
• 431-03-8 dimethylglyoxal 
• 501022-68-0 6-aminomethyl-3,5-dimethyl-1,2-dihydropyrazin-2-one 
• 501022-66-8 6-benzyloxycarbonylaminomethyl-3,5-dimethyl-1,2-dihydropyrazine-2-one 
• 80222-96-4 2-aminopropanamide hydrochloride 
• 870537-65-8 Boc-Ala-2,3-diaminopropionic acid(Z)-CH₂Cl 
• 71177-15-6 Boc-Ala-Ala-CH₂Cl 
• 50-99-7 D-glucose 
• 7658-08-4 D-quionovose 
• 4726-84-5 alanine amide 
• 51806-98-5 2-aminopropanenitrile 

Downstream Products

• 38052-24-3 1,3,5,6-tetramethylpyrazin-2-one 
• 97382-53-1 N-Methyl-N-(2-oxo-propionyl)-acetamide 
• 113934-96-6 1-(2-hydroxyethyl)-3,5,6-trimethyl-2-oxo-1,2-dihydropyrazine 
• 125186-38-1 2-acetyl-3,5,6-trimethylpyrazine 
• 820250-41-7 bromo-trimethyl-pyrazine 
• 68303-35-5 2-chloro-3,5,6-trimethylpyrazine 

Relevant academic research and scientific papers

3-Methyl-2(1H)-pyrazinones, the Asparagine-Specific Maillard Products Formed from Asparagine and Monosaccharides

Four unknown compounds from the reactions of monosaccharides and asparagine have been positively identified by spectroscopic elucidation and synthesis as 3,5-dimethyl-6-ethyl-2(1H)-pyrazinone, 3,6-dimethyl-5-ethyl-2(1H)-pyrazinone, 3,5,6-trimethyl-2(1H)-pyrazinone, and 3-methyl-5,6-diethyl-2(1H)-pyrazinone, which are novel to model reaction studies.This group of compounds can be recognized as asparagine-specific Maillard products.The formation mechanism of them has been proposed.Basically, 3-aminosuccinimide, asparagine, and isoasparagine may be at an equilibriumstate.Condensation of isoasparagine and α-dicarbonyls (the degradation products of the monosaccharide) leads to the formation of 3-(carboxymethyl)-5,6-dialkyl-2(1H)-pyrazinones, decarboxylation of which generates 3-methyl-5,6-dialkyl-2(1H)-pyrazinones.Identification of this group of compounds from Maillard reaction was herein reported for the first time in literature.Keywords: Asparagine; fructose; glucose; rhamnose; alkylpyrazines; Maillard reaction; 3,6-dimethyl-5-ethyl-2(1H)-pyrazinone; 3,5-dimethyl-6-ethyl-2(1H)-pyrazinone; 3,5,6-trimethyl-2(1H)-pyrazinone; 3-methyl-5,6-diethyl-2(1H)-pyrazinone; 3,6-dimethyl-5-propyl-2(1H)-pyrazinone; 3,5-dimethyl-6-propyl-2(1H)-pyrazinone

Studies on the mechanism of 1,2-dihydropyrazin-2-one ring formation from dipeptidyl chloromethyl ketone and its chemical properties: Immediate deamination during catalytic hydrogenation

1,2-Dihydropyrazin-2-one derivatives, which have two aminoalkyl groups at the positions 3 and 6, were found to be efficient tools for the construction of potent, selective and long-acting opioid mimetics. During the course of preparation, we found that the catalytic hydrogenation of 3,6- bis(benzyloxycarbonylaminomethyl)-5-methyl-1,2-dihydropyrazin-2-one to remove the benzyloxycarbonyl groups resulted in a side reaction. By MS and NMR studies and by preparation of additional 1,2-dihydropyrazin-2-one derivatives, the structure of the by-product was identified as 3-aminomethyl-5,6-dimethyl-1,2- dihydropyrazin-2-one. Preparation of additional compounds substituted with deuterium provided us with sufficient information to confirm the structure of the product and to support a cyclization mechanism in its formation.

Immediate deamination from the aminomethyl group attached to 1,2-dihydropyrazin-2-one derivative during catalytic hydrogenation

The catalytic hydrogenation of 3,6-bis(benzyloxycarbonylaminomethyl)-5-methyl-1,2-dihydropyrazin-2-one to remove benzyloxycarbonyl (Z) groups resulted in a side reaction. Purification by reverse-phase HPLC and analysis by proton nuclear magnetic resonance

PYRAZINES, PYRIMIDINES AND PYRIDAZINES USEFUL IN THE TREATMENT OF SENILE DEMENTIA

The present invention provides pyrazines, pyridazines or pyrimidines, or salts or prodrugs thereof, substituted on one of the ring carbon atoms thereof with a non-aromatic azacyclic or azabicyclic ring system; and independently substituted on each of the other ring carbon atoms with a substituent of low lipophilicity or a hydrocarbon substituent; which compounds stimulate central muscarinic acetylcholine receptors and therefore are useful in the treatment of neurological and mental illnesses.