(2R,3S,8R,9S,10S)-10-(2,4-Dihydroxy-phenyl)-8-(3,4-dihydroxy-phenyl)-2-(3-hydroxy-4-methoxy-phenyl)-3,4,9,10-tetrahydro-2H,8H-pyrano[2,3-f]chromene-3,5,9-triol

Base Information

• Chemical Name: (2R,3S,8R,9S,10S)-10-(2,4-Dihydroxy-phenyl)-8-(3,4-dihydroxy-phenyl)-2-(3-hydroxy-4-methoxy-phenyl)-3,4,9,10-tetrahydro-2H,8H-pyrano[2,3-f]chromene-3,5,9-triol
• CAS No.: 119002-92-5
• Molecular Formula: C₃₁H₂₈O₁₁
• Molecular Weight: 576.557
• Mol file: 119002-92-5.mol

Synonyms:

Chemical Property of (2R,3S,8R,9S,10S)-10-(2,4-Dihydroxy-phenyl)-8-(3,4-dihydroxy-phenyl)-2-(3-hydroxy-4-methoxy-phenyl)-3,4,9,10-tetrahydro-2H,8H-pyrano[2,3-f]chromene-3,5,9-triol

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (2R,3S,8R,9S,10S)-10-(2,4-Dihydroxy-phenyl)-8-(3,4-dihydroxy-phenyl)-2-(3-hydroxy-4-methoxy-phenyl)-3,4,9,10-tetrahydro-2H,8H-pyrano[2,3-f]chromene-3,5,9-triol

There total 6 articles about (2R,3S,8R,9S,10S)-10-(2,4-Dihydroxy-phenyl)-8-(3,4-dihydroxy-phenyl)-2-(3-hydroxy-4-methoxy-phenyl)-3,4,9,10-tetrahydro-2H,8H-pyrano[2,3-f]chromene-3,5,9-triol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(-)-Fisetinidol-(4α,8)-(+)-catechin 4-O(E)-methyl ether (118964-34-4) → dehydro-(-)-fisetinidol-(+)-catechin + (2R,3S,8R,9S,10S)-10-(2,4-Dihydroxy-phenyl)-8-(3,4-dihydroxy-phenyl)-2-(3-hydroxy-4-methoxy-phenyl)-3,4,9,10-tetrahydro-2H,8H-pyrano[2,3-f]chromene-3,5,9-triol (119002-92-5,119067-92-4)

Guidance literature:

With sodium hydrogencarbonate; sodium carbonate; In water; at 50 ℃; for 5h;

Reference yield:

(-)-fisetidinol-(4β,8)-(+)-catechin-O-methyl ether (119065-89-3) → 8,9-cis-9,10-trans-tetrahydro-2H,8H-pyrano<2,3-h>chromane (119067-92-4) + 8,9-trans-9,10-trans-tetrahydropyrano<2,3-h>chromene (119002-92-5) + (2R,3S:8S,9R,10S)-3,9-dihydroxy-2-(3-hydroxy-4-methoxyphenyl)-8-(2,4-dihydroxyphenyl)-10-(3,4-dihydroxyphenyl)-2,3-trans-8,9-trans-9,10-trans-3,4,9,10-tetrahydro-2H,8H-pyrano<2,3-h>chromene (119065-86-0) + 8,9-cis-9,10-trans-tetrahydropyrano<2,3-h>chromene (118964-24-2)

Guidance literature:

With sodium hydrogencarbonate; sodium carbonate; In water; at 50 ℃; for 3h;

Reference yield:

(2R,3S)-2-(4'-hydroxy-3'-methoxyphenyl)chroman-3,5,7-triol (69912-75-0) → (2R,3S,8R,9S,10S)-10-(2,4-Dihydroxy-phenyl)-8-(3,4-dihydroxy-phenyl)-2-(3-hydroxy-4-methoxy-phenyl)-3,4,9,10-tetrahydro-2H,8H-pyrano[2,3-f]chromene-3,5,9-triol (119002-92-5,119067-92-4)

Guidance literature:

Multi-step reaction with 2 steps

1: 0.1M HCl / ethanol / 24 h / Ambient temperature

2: 0.025M Na₂CO₃, 0.025M NaHCO₃ / H₂O / 5 h / 50 °C

With hydrogenchloride; sodium hydrogencarbonate; sodium carbonate; In ethanol; water;

upstream raw materials:

(+)-fisetinidol-(4β,8)-(+)-catechin O-methyl ether

(-)-fisetidinol-(4β,8)-(+)-catechin-O-methyl ether

(-)-Fisetinidol-(4α,8)-(+)-catechin 4-O(E)-methyl ether

(2R,3S)-2-(4'-hydroxy-3'-methoxyphenyl)chroman-3,5,7-triol

Downstream raw materials:

(2R,3S:8R,9S,10R)-3,9-diacetoxy-2,8-bis(3,4-dimethoxyphenyl)-10-(2,4-dimethoxyphenyl)-2,3-trans-8,9-trans-9,10-trans-3,4,9,10-tetrahydro-2H,8H-pyrano<2,3-h>chromene

(2R,3S,8R,9S,10R)-2,3-trans-8,9-trans-9,10-cis-3,9-diacetoxy-2,8-bis(3,4-dimethoxyphenyl)-10-(2,4-dimethoxyphenyl)-5-methoxy-3,4,9,10-tetrahydro-2H,8H-benzo<1,2-b; 3,4-b'>dipyran