[(3R,3aS,7aS)-7-[2-[(3S,5R)-3,5-Bis-methoxymethoxy-2-methylene-cyclohex-(Z)-ylidene]-eth-(E)-ylidene]-3-((R)-5-methoxymethoxy-1,5-dimethyl-hexyl)-octahydro-inden-3a-ylmethoxy]-tert-butyl-dimethyl-silane

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Chemical Name:[(3R,3aS,7aS)-7-[2-[(3S,5R)-3,5-Bis-methoxymethoxy-2-methylene-cyclohex-(Z)-ylidene]-eth-(E)-ylidene]-3-((R)-5-methoxymethoxy-1,5-dimethyl-hexyl)-octahydro-inden-3a-ylmethoxy]-tert-butyl-dimethyl-silane
CAS No.:141245-54-7
Molecular Formula:C₃₉H₇₀O₇Si
Molecular Weight:679.066
Hs Code.:

[(3R,3aS,7aS)-7-[2-[(3S,5R)-3,5-Bis-methoxymethoxy-2-methylene-cyclohex-(Z)-ylidene]-eth-(E)-ylidene]-3-((R)-5-methoxymethoxy-1,5-dimethyl-hexyl)-octahydro-inden-3a-ylmethoxy]-tert-butyl-dimethyl-silane

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Chemical Property of [(3R,3aS,7aS)-7-[2-[(3S,5R)-3,5-Bis-methoxymethoxy-2-methylene-cyclohex-(Z)-ylidene]-eth-(E)-ylidene]-3-((R)-5-methoxymethoxy-1,5-dimethyl-hexyl)-octahydro-inden-3a-ylmethoxy]-tert-butyl-dimethyl-silane

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Technology Process of [(3R,3aS,7aS)-7-[2-[(3S,5R)-3,5-Bis-methoxymethoxy-2-methylene-cyclohex-(Z)-ylidene]-eth-(E)-ylidene]-3-((R)-5-methoxymethoxy-1,5-dimethyl-hexyl)-octahydro-inden-3a-ylmethoxy]-tert-butyl-dimethyl-silane

There total 14 articles about [(3R,3aS,7aS)-7-[2-[(3S,5R)-3,5-Bis-methoxymethoxy-2-methylene-cyclohex-(Z)-ylidene]-eth-(E)-ylidene]-3-((R)-5-methoxymethoxy-1,5-dimethyl-hexyl)-octahydro-inden-3a-ylmethoxy]-tert-butyl-dimethyl-silane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 113375-51-2
(3S,5R)-1-ethynyl-3,5-dihydroxy-2-methylcyclohex-1-ene

: 141245-54-7
[(3R,3aS,7aS)-7-[2-[(3S,5R)-3,5-Bis-methoxymethoxy-2-methylene-cyclohex-(Z)-ylidene]-eth-(E)-ylidene]-3-((R)-5-methoxymethoxy-1,5-dimethyl-hexyl)-octahydro-inden-3a-ylmethoxy]-tert-butyl-dimethyl-silane

Guidance literature:: Multi-step reaction with 4 steps

1: i-Pr₂NEt

2: 74 percent / Et₃N / (Ph₃P)2PdCl₂ / dimethylformamide / 1.25 h / 70 - 75 °C

3: 93 percent / quinoline, H₂ / Lindlar catalyst / hexane / 0.25 h / Ambient temperature

4: 2,2,4-trimethyl-pentane / 5 h / 100 °C

With quinoline; hydrogen; triethylamine; N-ethyl-N,N-diisopropylamine; bis-triphenylphosphine-palladium(II) chloride; Lindlar's catalyst; In 2,2,4-trimethylpentane; hexane; N,N-dimethyl-formamide;
DOI:10.1016/S0040-4039(00)91659-9

Reference yield:

: 116506-67-3
TB

: 141245-54-7
[(3R,3aS,7aS)-7-[2-[(3S,5R)-3,5-Bis-methoxymethoxy-2-methylene-cyclohex-(Z)-ylidene]-eth-(E)-ylidene]-3-((R)-5-methoxymethoxy-1,5-dimethyl-hexyl)-octahydro-inden-3a-ylmethoxy]-tert-butyl-dimethyl-silane

Guidance literature:: Multi-step reaction with 5 steps

1: n-BuNF / tetrahydrofuran

2: i-Pr₂NEt

3: 74 percent / Et₃N / (Ph₃P)2PdCl₂ / dimethylformamide / 1.25 h / 70 - 75 °C

4: 93 percent / quinoline, H₂ / Lindlar catalyst / hexane / 0.25 h / Ambient temperature

5: 2,2,4-trimethyl-pentane / 5 h / 100 °C

With quinoline; hydrogen; triethylamine; N-ethyl-N,N-diisopropylamine; bis-triphenylphosphine-palladium(II) chloride; Lindlar's catalyst; In tetrahydrofuran; 2,2,4-trimethylpentane; hexane; N,N-dimethyl-formamide;
DOI:10.1016/S0040-4039(00)91659-9

Reference yield:

: 135359-40-9
de-A,B-24-(methoxycarbonyl)-cholestan-8β-ol

: 141245-54-7
[(3R,3aS,7aS)-7-[2-[(3S,5R)-3,5-Bis-methoxymethoxy-2-methylene-cyclohex-(Z)-ylidene]-eth-(E)-ylidene]-3-((R)-5-methoxymethoxy-1,5-dimethyl-hexyl)-octahydro-inden-3a-ylmethoxy]-tert-butyl-dimethyl-silane

Guidance literature:: Multi-step reaction with 11 steps

1: 62 percent / Pb(OAc)4 / benzene / 22 h / Heating

2: 95 percent / diethyl ether / -78 deg C to r.t.

3: 56 percent / NaIO₄, RuO₄*H₂O / CCl₄; H₂O; acetonitrile / 360 h / Ambient temperature

4: 98 percent / i-Pr₂NH, DMAP / CH₂Cl₂ / a) 0 deg C, 6 h, b) r.t., 12 h

5: 99 percent / diisobutylaluminum hydride (DIBAL-H) / tetrahydrofuran; toluene / a) -78 deg C, 15 min, b) -78 deg C to r.t.

6: 76 percent / imidazole / CH₂Cl₂; dimethylformamide / 1 h / Ambient temperature

7: 87 percent / pyridinium dichromate, PPTS / CH₂Cl₂ / a) 0 deg C, 1 h, b) r.t., 4 h

8: 82 percent / LDA / tetrahydrofuran / 2 h / -78 deg C to r.t.

9: 74 percent / Et₃N / (Ph₃P)2PdCl₂ / dimethylformamide / 1.25 h / 70 - 75 °C

10: 93 percent / quinoline, H₂ / Lindlar catalyst / hexane / 0.25 h / Ambient temperature

11: 2,2,4-trimethyl-pentane / 5 h / 100 °C

With 1H-imidazole; quinoline; lead(IV) acetate; dmap; sodium periodate; dipyridinium dichromate; ruthenium tetroxide; hydrogen; pyridinium p-toluenesulfonate; diisobutylaluminium hydride; triethylamine; diisopropylamine; lithium diisopropyl amide; bis-triphenylphosphine-palladium(II) chloride; Lindlar's catalyst; In tetrahydrofuran; tetrachloromethane; 2,2,4-trimethylpentane; diethyl ether; hexane; dichloromethane; water; N,N-dimethyl-formamide; toluene; acetonitrile; benzene;
DOI:10.1016/S0040-4039(00)91659-9