(S)-2-[2-(2-{(S)-2-[(S)-2-{3-[2-((S)-2-tert-Butoxycarbonylamino-propionyloxy)-4,6-dimethyl-phenyl]-3-methyl-butyrylamino}-3-(1H-indol-3-yl)-propionylamino]-propionylamino}-acetylamino)-acetylamino]-succinic acid 4-benzyl ester

Base Information

Chemical Name:(S)-2-[2-(2-{(S)-2-[(S)-2-{3-[2-((S)-2-tert-Butoxycarbonylamino-propionyloxy)-4,6-dimethyl-phenyl]-3-methyl-butyrylamino}-3-(1H-indol-3-yl)-propionylamino]-propionylamino}-acetylamino)-acetylamino]-succinic acid 4-benzyl ester
CAS No.:197143-03-6
Molecular Formula:C₅₀H₆₃N₇O₁₃
Molecular Weight:970.089
Hs Code.:

(S)-2-[2-(2-{(S)-2-[(S)-2-{3-[2-((S)-2-tert-Butoxycarbonylamino-propionyloxy)-4,6-dimethyl-phenyl]-3-methyl-butyrylamino}-3-(1H-indol-3-yl)-propionylamino]-propionylamino}-acetylamino)-acetylamino]-succinic acid 4-benzyl ester

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Chemical Property of (S)-2-[2-(2-{(S)-2-[(S)-2-{3-[2-((S)-2-tert-Butoxycarbonylamino-propionyloxy)-4,6-dimethyl-phenyl]-3-methyl-butyrylamino}-3-(1H-indol-3-yl)-propionylamino]-propionylamino}-acetylamino)-acetylamino]-succinic acid 4-benzyl ester

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Technology Process of (S)-2-[2-(2-{(S)-2-[(S)-2-{3-[2-((S)-2-tert-Butoxycarbonylamino-propionyloxy)-4,6-dimethyl-phenyl]-3-methyl-butyrylamino}-3-(1H-indol-3-yl)-propionylamino]-propionylamino}-acetylamino)-acetylamino]-succinic acid 4-benzyl ester

There total 14 articles about (S)-2-[2-(2-{(S)-2-[(S)-2-{3-[2-((S)-2-tert-Butoxycarbonylamino-propionyloxy)-4,6-dimethyl-phenyl]-3-methyl-butyrylamino}-3-(1H-indol-3-yl)-propionylamino]-propionylamino}-acetylamino)-acetylamino]-succinic acid 4-benzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 187978-56-9
C₅₂H₆₄Cl₃N₇O₁₃

: 197143-03-6
(S)-2-[2-(2-{(S)-2-[(S)-2-{3-[2-((S)-2-tert-Butoxycarbonylamino-propionyloxy)-4,6-dimethyl-phenyl]-3-methyl-butyrylamino}-3-(1H-indol-3-yl)-propionylamino]-propionylamino}-acetylamino)-acetylamino]-succinic acid 4-benzyl ester

Guidance literature:: With zinc; In acetic acid; for 24h; Ambient temperature;
DOI:10.1021/jo961778z

Reference yield:

: 7536-58-5,98482-77-0
BOC-L-aspartic acid 4-benzyl ester

: 197143-03-6
(S)-2-[2-(2-{(S)-2-[(S)-2-{3-[2-((S)-2-tert-Butoxycarbonylamino-propionyloxy)-4,6-dimethyl-phenyl]-3-methyl-butyrylamino}-3-(1H-indol-3-yl)-propionylamino]-propionylamino}-acetylamino)-acetylamino]-succinic acid 4-benzyl ester

Guidance literature:: Multi-step reaction with 8 steps

1: 83 percent / DMAP, EDC / CH₂Cl₂ / 1.) 0 deg C, 3 h, 2.) room temperature, 21 h

2: 100 percent / TFA / CH₂Cl₂ / 0.75 h / Ambient temperature

3: 86 percent / EDC, HOBt, NMM / CH₂Cl₂ / 1.) 0 deg C, 4 h, 2.) room temperature, 24 h

4: 95 percent / TFA / CH₂Cl₂ / 1 h / Ambient temperature

5: 86 percent / EDC, HOBt, NMM / CH₂Cl₂ / 1.) 0 deg C, 4 h, 2.) room temperature, 24 h

6: 95 percent / TFA / CH₂Cl₂ / 1 h / Ambient temperature

7: 68 percent / EDC, HOBt, NMM / CH₂Cl₂ / 1.) 0 deg C, 2 h, 2.) room temperature, 30 h

8: Zn / acetic acid / 24 h / Ambient temperature

With 4-methyl-morpholine; dmap; benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; trifluoroacetic acid; zinc; In dichloromethane; acetic acid;
DOI:10.1021/jo961778z

Reference yield:

: 2483-49-0
tert-butyloxycarbonyl-L-alanine p-nitrophenyl ester

: 197143-03-6
(S)-2-[2-(2-{(S)-2-[(S)-2-{3-[2-((S)-2-tert-Butoxycarbonylamino-propionyloxy)-4,6-dimethyl-phenyl]-3-methyl-butyrylamino}-3-(1H-indol-3-yl)-propionylamino]-propionylamino}-acetylamino)-acetylamino]-succinic acid 4-benzyl ester

Guidance literature:: Multi-step reaction with 6 steps

1: 84 percent / DMAP / CH₂Cl₂ / 14 h / Heating

2: 4.8 g / AcOH, H₂O / tetrahydrofuran / 1 h / Ambient temperature

3: 79 percent / PCC / CH₂Cl₂ / 1 h / Ambient temperature

4: 88 percent / KMnO₄ / acetone; H₂O / 17 h / Ambient temperature

5: 68 percent / EDC, HOBt, NMM / CH₂Cl₂ / 1.) 0 deg C, 2 h, 2.) room temperature, 30 h

6: Zn / acetic acid / 24 h / Ambient temperature

With 4-methyl-morpholine; dmap; potassium permanganate; water; benzotriazol-1-ol; acetic acid; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; pyridinium chlorochromate; zinc; In tetrahydrofuran; dichloromethane; water; acetic acid; acetone;
DOI:10.1021/jo961778z