1-Pyrrolidinecarboxylic acid, 3-azido-, 1,1-dimethylethyl ester, (3S)-

Base Information

• Chemical Name: 1-Pyrrolidinecarboxylic acid, 3-azido-, 1,1-dimethylethyl ester, (3S)-
• CAS No.: 125552-56-9
• Molecular Formula: C9H16N4O2
• Molecular Weight: 212.24900
• Mol file: 125552-56-9.mol

Synonyms:N- (tert-butoxy carbonyl)-3S-azido pyrrolidine;

Chemical Property of 1-Pyrrolidinecarboxylic acid, 3-azido-, 1,1-dimethylethyl ester, (3S)-

Chemical Property:

• PSA: 79.29000
• LogP: 1.69676

Purity/Quality:

95%-98% ^*data from raw suppliers

1,1-Dimethylethyl(3S)-3-azidopyrrolidine-1-carboxylate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-Pyrrolidinecarboxylic acid, 3-azido-, 1,1-dimethylethyl ester, (3S)-

There total 7 articles about 1-Pyrrolidinecarboxylic acid, 3-azido-, 1,1-dimethylethyl ester, (3S)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

tert-butyl (3R)-3-methylsulfonyloxypyrrolidine-1-carboxylate (127423-61-4) → (S)-tert-butyl 3-azidopyrrolidine-1-carboxylate (125552-56-9)

Guidance literature:

With sodium azide; In N,N-dimethyl-formamide; at 95 ℃; for 20h;

Reference yield: 87.0%

1,1-dimethylethyl-3(R)-{[(4-methylphenyl)sulphonyl]oxy}-1-pyrrolidinecarboxylate (139986-03-1,371240-55-0) → (S)-tert-butyl 3-azidopyrrolidine-1-carboxylate (125552-56-9)

Guidance literature:

With sodium azide; In N,N-dimethyl-formamide; at 80 ℃; for 2h; Inert atmosphere;

Reference yield: 81.0%

(S)-tert-butyl 3-(methylsulfonyloxy)pyrrolidine-1-carboxylate (132945-75-6) → (S)-tert-butyl 3-azidopyrrolidine-1-carboxylate (125552-56-9)

Guidance literature:

With sodium azide; In N,N-dimethyl-formamide; at 60 ℃; for 6h;

upstream raw materials:

tert-butyl (3R)-3-methylsulfonyloxypyrrolidine-1-carboxylate

(S)-tert-butyl 3-(methylsulfonyloxy)pyrrolidine-1-carboxylate

di-tert-butyl dicarbonate

(R)-tert-butyl 3-hydroxypyrrolidine-1-carboxylate

Downstream raw materials:

tert-butyl (3S)-3-(2-aminoacetylamino)-1-pyrrolidinecarboxylate

tert-butyl (3S)-3-acetamidopyrrolidine-1-carboxylate

C₂₆H₃₀N₆O₁₀

C₁₆H₂₂N₂O₄

Refernces

• 1、 -. "Aromatic heterocyclic derivatives and applications of aromatic heterocyclic derivatives in medicines". Paragraph 1337-1339. . Retrieved 2016/10/09.
• 2、 -. "Anti-infective compounds". Page/Page column 33. . Retrieved 2011/08/04.