Technology Process of L-δ-Hydroxynorvaline
There total 5 articles about L-δ-Hydroxynorvaline which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
hydrogenchloride;
In
water;
at 100 ℃;
for 2h;
DOI:10.1021/jo026479q
- Guidance literature:
-
Multi-step reaction with 5 steps
1: 100 percent / p-toluenesulfonic acid / toluene / 1.67 h / Heating
2: 100 percent / oxalyl chloride; DMF / CH2Cl2 / 0.5 h / 20 °C
3: 48 percent / D2; lutidine / 5percent Pd/BaSO4 / tetrahydrofuran / 2 h / 20 °C
4: 19 percent / (S)-Alpine borane / tetrahydrofuran / 10 h / 20 °C
5: 91 percent / hydrochloric acid / H2O / 2 h / 100 °C
With
hydrogenchloride; oxalyl dichloride; (S)-alpine borane; lutidine; toluene-4-sulfonic acid; N,N-dimethyl-formamide; deuterium;
5percent Pd/BaSO4;
In
tetrahydrofuran; dichloromethane; water; toluene;
3: Rosenmund reduction / 4: Midland reduction;
DOI:10.1021/jo026479q
- Guidance literature:
-
Multi-step reaction with 3 steps
1: 48 percent / D2; lutidine / 5percent Pd/BaSO4 / tetrahydrofuran / 2 h / 20 °C
2: 19 percent / (S)-Alpine borane / tetrahydrofuran / 10 h / 20 °C
3: 91 percent / hydrochloric acid / H2O / 2 h / 100 °C
With
hydrogenchloride; S-alpine borane; lutidine; deuterium;
5percent Pd/BaSO4;
In
tetrahydrofuran; water;
1: Rosenmund reduction / 2: Midland reduction;
DOI:10.1021/jo026479q