(-)-(1'R)-(2',2'-Dimethylspiro<2.4>hepta-4',6'-dien-1-yl)methyl menthyl carbonate

Base Information

• Chemical Name: (-)-(1'R)-(2',2'-Dimethylspiro<2.4>hepta-4',6'-dien-1-yl)methyl menthyl carbonate
• CAS No.: 146564-72-9
• Molecular Formula: C₂₁H₃₂O₃
• Molecular Weight: 332.483
• Mol file: 146564-72-9.mol

Synonyms:

Chemical Property of (-)-(1'R)-(2',2'-Dimethylspiro<2.4>hepta-4',6'-dien-1-yl)methyl menthyl carbonate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (-)-(1'R)-(2',2'-Dimethylspiro<2.4>hepta-4',6'-dien-1-yl)methyl menthyl carbonate

There total 2 articles about (-)-(1'R)-(2',2'-Dimethylspiro<2.4>hepta-4',6'-dien-1-yl)methyl menthyl carbonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(-)-menthol (2216-51-5) → (-)-(1'R)-(2',2'-Dimethylspiro<2.4>hepta-4',6'-dien-1-yl)methyl menthyl carbonate (146564-72-9)

Guidance literature:

Multi-step reaction with 2 steps

1: quinoline / toluene / 0 °C

2: 0.65 g / NEt₃ / benzene

With quinoline; triethylamine; In toluene; benzene;

DOI:10.1021/jo00060a039

Reference yield:

(1R,2S,5R)-menthyl chloroformate (14602-86-9,7635-53-2) + 2',2'-Dimethyl-1'-(hydroxymethyl)spiro<2.4>hepta-4',6'-diene (126899-48-7) → (-)-(1'R)-(2',2'-Dimethylspiro<2.4>hepta-4',6'-dien-1-yl)methyl menthyl carbonate (146564-72-9)

Guidance literature:

With triethylamine; In benzene;

DOI:10.1021/jo00060a039

upstream raw materials:

(1R,2S,5R)-menthyl chloroformate

2',2'-Dimethyl-1'-(hydroxymethyl)spiro<2.4>hepta-4',6'-diene

(-)-menthol