Tert-butyl 4-hydroxytetrahydrofuran-3-carboxylate

Base Information

Chemical Name:Tert-butyl 4-hydroxytetrahydrofuran-3-carboxylate
CAS No.:797038-33-6
Molecular Formula:C₉H₁₆O₄
Molecular Weight:188.224
Hs Code.:
DSSTox Substance ID:DTXSID801198791

Synonyms:tert-butyl 4-hydroxytetrahydrofuran-3-carboxylate;797038-33-6;Tert-butyl 4-hydroxyoxolane-3-carboxylate;t-butyl 4-hydroxytetrahydrofuran-3-carboxylate;SCHEMBL1267055;KSFWORQWMLHPPN-UHFFFAOYSA-N;DTXSID801198791;MFCD28363986;AKOS034831980;LS-11430;FT-0754495;W19594;1,1-Dimethylethyl tetrahydro-4-hydroxy-3-furancarboxylate

Suppliers and Price of Tert-butyl 4-hydroxytetrahydrofuran-3-carboxylate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Matrix Scientific
tert-Butyl 4-hydroxytetrahydrofuran-3-carboxylate
5g
$ 2200.00

Matrix Scientific
tert-Butyl 4-hydroxytetrahydrofuran-3-carboxylate
1g
$ 600.00

Matrix Scientific
tert-Butyl 4-hydroxytetrahydrofuran-3-carboxylate
0.500g
$ 480.00

Total 1 raw suppliers

Chemical Property of Tert-butyl 4-hydroxytetrahydrofuran-3-carboxylate

Chemical Property:

Boiling Point:274.8±40.0 °C(Predicted)
Density:1.148±0.06 g/cm3(Predicted)
XLogP3:0.6
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:3
Exact Mass:188.10485899
Heavy Atom Count:13
Complexity:194

Purity/Quality:: tert-Butyl 4-hydroxytetrahydrofuran-3-carboxylate ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC(C)(C)OC(=O)C1COCC1O

Technology Process of Tert-butyl 4-hydroxytetrahydrofuran-3-carboxylate

There total 3 articles about Tert-butyl 4-hydroxytetrahydrofuran-3-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

: 797038-32-5
tert-butyl 4-oxotetrahydrofuran-3-carboxylate

: 797038-33-6
tert-butyl 4-hydroxytetrahydrofuran-3-carboxylate

Guidance literature:: With sodium tetrahydroborate; In isopropyl alcohol; at 0 - 20 ℃;
DOI:10.1039/b407558g

Reference yield:

: 1663-39-4,25232-27-3
tert-Butyl acrylate

: 797038-33-6
tert-butyl 4-hydroxytetrahydrofuran-3-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1.1: NaH / diethyl ether / 0.5 h / 20 °C

1.2: 68 percent / dimethylsulfoxide / 0.5 h / 20 °C

2.1: 89 percent / NaBH₄ / propan-2-ol / 0 - 20 °C

With sodium tetrahydroborate; sodium hydride; In diethyl ether; isopropyl alcohol;
DOI:10.1039/b407558g

Reference yield:

: 1663-39-4,25232-27-3
tert-Butyl acrylate

: 797038-33-6
tert-butyl 4-hydroxytetrahydrofuran-3-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1.1: sodium hydride / diethyl ether / 0.5 h / 20 °C / Inert atmosphere

1.2: 0.5 h / 0 - 20 °C

2.1: sodium tetrahydroborate / isopropyl alcohol / 0 - 20 °C

With sodium tetrahydroborate; sodium hydride; In diethyl ether; isopropyl alcohol;