797038-32-5

Upstream product

• 1663-39-4 tert-Butyl acrylate 
• 623-50-7 ethyl 2-hydroxyacetate 

Downstream Products

• 797038-34-7 tert-butyl 2,5-dihydrofuran-3-carboxylate 
• 164916-44-3 (3R,4R)-4-aminotetrahydrofuran-3-carboxylic acid 
• 164916-44-3 (3S,4R)-4-aminotetrahydrofuran-3-carboxylic acid 
• 797038-52-9 tert-butyl (3R,4R,αS)-4-(N-benzyl-N-α-methylbenzylamino)tetrahydrofuran-3-carboxylate 
• 797038-51-8 tert-butyl (3S,4R,αS)-4-(N-benzyl-N-α-methylbenzylamino)tetrahydrofuran-3-carboxylate 
• 1422196-72-2 C₁₇H₂₅NO₃*ClH 
• 2162117-48-6 C₁₈H₂₅NO₃ 

Relevant academic research and scientific papers

ANTIBACTERIAL COMPOUNDS

This invention relates to antibacterial and antimycobacterial drug compounds of formula (I). It also relates to pharmaceutical formulations of antibacterial drug compounds of formula (I). It also relates to uses of the derivatives in treating bacterial infections and to methods of treating bacterial infections. The compounds are particularly useful for treating bacterial infections that have developed resistance to other drug compounds, e.g. resistant strains of S. aureus.

MELANOCORTIN RECEPTOR AGONISTS

The present invention relates to a compound of the following formula 1, pharmaceutically acceptable salt and isomer thereof effective as agonist of melanocortin receptor, and an agonistic composition of melanocortin receptor comprising the same as active ingredient.

Asymmetric synthesis of the cis- And trans-stereoisomers of 4-aminopyrrolidine-3-carboxylic acid and 4-aminotetrahydrofuran-3-carboxylic acid

The diastereoselective conjugate addition of lithium (S)-N-benzyl-N- α-methylbenzylamide has been successfully applied to the first asymmetric syntheses of cis-(3S,4R)- and fraBs-(3R,4R)-4-arninotetrahydrofuran-3-carboxylic acids (26% and 25% overall yield respectively, >98% d.e. and >97% e.e. in each case). Furthermore, the most efficient asymmetric synthesis to date of cis-(3R,4R)- and trans-(3R,4S)-4-aminopyrrolidine carboxylic acids is delineated: for cis-(3R,4R), four steps, >98% d.e., 52% overall yield; for trans-(3R,4S), five steps, >98% d.e., 50% overall yield.